The GenePOC Platform, a Rational Solution for Extreme Point-of-Care Testing

Bissonnette, Luc; Bergeron, Michel G.

doi:10.3390/mi7060094

Cited by 26 publications

(20 citation statements)

References 65 publications

(90 reference statements)

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“…Its universal sample-to-cartridge interface (accepts liquefied matrix) allows compatibility with several types of swabs, urine, etc. [182].…”

Section: Genepoc™ Platform Description and Performancementioning

confidence: 99%

“…The cartridge consists of only three pieces of plastic and has a wedge-shaped form (unlike an entire disk), which allows the device to process up to eight cartridges simultaneously, thus offering an increased throughput that is often necessary in cases of "extreme" POC testing [182]. The GenePOC™ disposable is composed of three distinct operational sectors: (i) World-to-chip interface: 100 to 200 μL of clinical sample conditioned in GenePOC™ sample buffer is inserted in the disposable with a transfer pipette.…”

Section: Technology and Operating Principlementioning

confidence: 99%

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Diagnostic tools for tackling febrile illness and enhancing patient management

Mitsakakis

D’Acremont

Hin

et al. 2018

Microelectronic Engineering

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A B S T R A C TMost patients with acute infectious diseases develop fever, which is frequently a reason to visit health facilities in resource-limited settings. The symptomatic overlap between febrile diseases impedes their diagnosis on clinical grounds. Therefore, the World Health Organization promotes an integrated management of febrile illness. Along this line, we present an overview of endemic and epidemic etiologies of fever and state-of-the-art diagnostic tools used in the field. It becomes evident that there is an urgent need for the development of novel technologies to fulfill end-users' requirements. This need can be met with point-of-care and near-patient diagnostic platforms, as well as e-Health clinical algorithms, which co-assess test results with key clinical elements and biosensors, assisting clinicians in patient triage and management, thus enhancing disease surveillance and outbreak alerts. This review gives an overview of diagnostic technologies featuring a platform based approach: (i) assay (nucleic acid amplification technologies are examined); (ii) cartridge (microfluidic technologies are presented); (iii) instrument (various detection technologies are discussed); and at the end proposes a way that such technologies can be interfaced with electronic clinical decision-making algorithms towards a broad and complete diagnostic ecosystem.

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“…Its universal sample-to-cartridge interface (accepts liquefied matrix) allows compatibility with several types of swabs, urine, etc. [182].…”

Section: Genepoc™ Platform Description and Performancementioning

confidence: 99%

Section: Technology and Operating Principlementioning

confidence: 99%

Diagnostic tools for tackling febrile illness and enhancing patient management

Mitsakakis

D’Acremont

Hin

et al. 2018

Microelectronic Engineering

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“…technology research has been performed in the fields of medical diagnostic and forensic science that could be adapted to forestry (Montpetit et al 2005;Bissonnette and Bergeron 2016). Conservation-based initiatives are also currently being implemented by some organizations (e.g., Conservation X Labs), in collaboration with governments, universities, corporations and NGOs (e.g., WWF), with the goal of developing rapid identification technologies for living material.…”

Section: The Applicability Challengementioning

confidence: 99%

Genomic tools for traceability: Opportunities, challenges and perspectives for the Canadian forestry sector

Godbout

BomalClaude

FarrKen

et al. 2018

The Forestry Chronicle

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Consumers, retailers, investors, and governments want quality products that are both safe and obtained through legal and sustainable practices. The solution put into place to meet those challenges requires the implementation of a traceability system. In the context of forestry, traceability is the ability to inform about the identity or provenance of a wood product. The principle of traceability helps establish trust among the various stakeholders throughout the value chain. To this day, most traceability systems are based on paper permits, which are easier to falsify than systems that are based on genetic markers. In this manuscript, we define the elements of a traceability system based on genomic tools that could be useful for the Canadian forest sector. We also present several examples in which genomic tools are or could be used as traceability systems. Genomic tools and data happen to be available in quantity for several forest species and they could constitute the basis for the development of such traceability systems. Our aim is to demonstrate that there are actually great opportunities to develop such systems that could be applied to the Canadian forest sector.Keywords: traceability, genomic, markets, certification, sustainability, urban forestry, quality control, value chain, taxonomy, origin, database RÉSUMÉ:Les consommateurs, les détaillants, les investisseurs et les gouvernements veulent des produits de qualité, sécuritaires et qui résultent de pratiques légales et durables. Les principes de la traçabilité permettent de répondre à ces différents enjeux. Dans le contexte forestier, la traçabilité est la capacité d'informer sur l'identité ou la provenance d'un produit du bois. Ce principe aide à établir la confiance entre les différents acteurs de la chaîne de valeur. À ce jour, la plupart des systèmes de traçabilité sont basés sur des permis en papier qui sont facilement falsifiables. Dans ce manuscrit, nous définissons les élé-ments d'un système de traçabilité basé sur des outils génomiques qui pourrait être utile pour le secteur forestier canadien. Nous présentons aussi plusieurs exemples de la façon dont les outils de la génomique sont ou pourraient être utilisés. Des données et des outils génomiques sont actuellement disponibles en grandes quantités pour plusieurs essences forestières et ceux-ci pourraient constituer la base du développement de tels systèmes de traçabilité. Notre objectif est de démontrer qu'il y a actuellement de grandes opportunités pour développer de tels systèmes qui pourraient s'appliquer au secteur forestier canadien.

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“…Unfortunately, conducting RT-qPCR diagnostics often depends on access to centralized laboratory facilities for testing [21][22][23]. To resolve this limitation, several different versions of compact PCR platforms (some of them q-PCR systems) have been described recently in the scientific literature [24][25][26][27]. Unfortunately, most of these devices have not yet reached the market.…”

Section: Introductionmentioning

confidence: 99%

Portable and accurate diagnostics for COVID-19: Combined use of the miniPCR thermocycler and a well-plate reader for SARS-CoV-2 virus detection

et al. 2020

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The coronavirus disease 2019 (COVID-19) pandemic has crudely demonstrated the need for massive and rapid diagnostics. By the first week of July, more than 10,000,000 positive cases of COVID-19 have been reported worldwide, although this number could be greatly underestimated. In the case of an epidemic emergency, the first line of response should be based on commercially available and validated resources. Here, we demonstrate the use of the miniPCR, a commercial compact and portable PCR device recently available on the market, in combination with a commercial well-plate reader as a diagnostic system for detecting genetic material of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19. We used the miniPCR to detect and amplify SARS-CoV-2 DNA sequences using the sets of initiators recommended by the World Health Organization (WHO) for targeting three different regions that encode for the N protein. Prior to amplification, samples were combined with a DNA intercalating reagent (i.e., EvaGreen Dye). Sample fluorescence after amplification was then read using a commercial 96-well plate reader. This straightforward method allows the detection and amplification of SARS-CoV-2 nucleic acids in the range of~625 to 2×10 5 DNA copies. The accuracy and simplicity of this diagnostics strategy may provide a cost-efficient and reliable alternative for COVID-19 pandemic testing, particularly in underdeveloped regions where RT-QPCR instrument availability may be limited. The portability, ease of use, and reproducibility of the miniPCR makes it a reliable alternative for deployment in point-of-care SARS-CoV-2 detection efforts during pandemics.

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The GenePOC Platform, a Rational Solution for Extreme Point-of-Care Testing

Cited by 26 publications

References 65 publications

Diagnostic tools for tackling febrile illness and enhancing patient management

Diagnostic tools for tackling febrile illness and enhancing patient management

Genomic tools for traceability: Opportunities, challenges and perspectives for the Canadian forestry sector

Portable and accurate diagnostics for COVID-19: Combined use of the miniPCR thermocycler and a well-plate reader for SARS-CoV-2 virus detection

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