The General Neurotic Syndrome: A Re-Evaluation

Tyrer, Peter; Tyrer, Helen; Guo, Boliang

doi:10.1159/000444196

Cited by 30 publications

(27 citation statements)

References 36 publications

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“…Further, high sensitivity is required for detecting residual symptomatology, which was found to characterize the majority of patients who were judged to be remitted according to DSM criteria and no longer in need of active treatment [39]. Excessive reliance on symptoms that are part of diagnostic criteria of mental disorders (e.g., major depressive disorder, generalized anxiety disorder) has impoverished clinical assessment in psychopharmacology and does not reflect the broad spectrum of variables that affect clinical presentations: subclinical distress [39], such as demoralization and irritable mood [40], psychological well-being and euthymia [41,42,43], mental pain [44,45,46,47], social adjustment [48], and neuroticism [49,50]. …”

Section: Areas Of Applicationmentioning

confidence: 99%

Clinical Pharmacopsychology: Conceptual Foundations and Emerging Tasks

Fava

Tomba

Bech

2017

Psychother Psychosom

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The aim of this critical review was to outline emerging trends and perspectives of clinical pharmacopsychology, an area of clinical psychology that is concerned with the psychological effects of medications. The historical development of clinical pharmacopsychology is outlined, with discussion of its most representative expressions and reference to current challenges of clinical research, with particular reference to clinimetrics. The domains of clinical pharmacopsychology encompass the clinical benefits of psychotropic drugs, the characteristics that predict responsiveness to treatment, the vulnerabilities induced by treatment (side effects, behavioral toxicity, iatrogenic comorbidity), and the interactions between drug treatment and psychological variables. Its aim is to provide a comprehensive assessment of the clinical important changes that are concerned with (a) wanted and expected treatment effects, (b) treatment-induced unwanted side effects, and (c) the patient's own personal experience of a change in terms of well-being and/or quality of life. Clinical pharmacopsychology offers a unifying framework for the understanding of clinical phenomena in medical and psychiatric settings. Research in this area deserves high priority.

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Section: Areas Of Applicationmentioning

confidence: 99%

Clinical Pharmacopsychology: Conceptual Foundations and Emerging Tasks

Fava

Tomba

Bech

2017

Psychother Psychosom

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“…The mixture of anxiety or phobia and obsessive-compulsive states referred to as co-thymia by Tyrer et al [1] covers Freud's ‘Die gemischte Neurose' [2]. Many of the patients classified by Tyrer et al [1] as suffering from a general neurotic syndrome have personality dysfunctions to be taken into account in the treatment plan.…”

Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

“…Many of the patients classified by Tyrer et al [1] as suffering from a general neurotic syndrome have personality dysfunctions to be taken into account in the treatment plan. In the new ICD-11, these patients would be referred to as having negative affective domain traits [1]. However, whereas Tyrer et al [1] have used clinician-rated assessments of these personality dysfunctions, Eysenck focussed on self-reported assessment in his personality questionnaires.…”

Section: Tablementioning

confidence: 99%

“…In the new ICD-11, these patients would be referred to as having negative affective domain traits [1]. However, whereas Tyrer et al [1] have used clinician-rated assessments of these personality dysfunctions, Eysenck focussed on self-reported assessment in his personality questionnaires. As early as in the first version of his neuroticism scale in the Maudsley Medical Questionnaire, Eysenck made an attempt to measure the spectrum of the corresponding dysthymia trait.…”

Section: Tablementioning

confidence: 99%

See 2 more Smart Citations

The Items Predicting Non-Remission after 6 Months of Treatment of Patients with Generalized Anxiety Disorder Covered the Eysenck Neuroticism Components of Anxiety, Interpersonal Sensitivity and Depression

Bech

Rickels²

2016

Psychother Psychosom

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What psychologists need to know about psychotropic medications

Tomba

Guidi

Fava

2017

Clin Psychology and Psychoth

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Despite the fact that today most of the patients with psychological disturbances assume some form of psychotropic drug treatment, clinical psychologists may have little familiarity with psychopharmacology and are substantially unaware of subtle and yet pervasive potential effects of medications in clinical presentations. In their training, psychologists are generally exposed, at best, to some general principles of drug action. Standard psychopharmacology textbooks tend to omit the subtle psychological changes that may occur during psychotropic drug treatment. Clinical pharmacopsychology consists of the application of clinical psychology to the full understanding of pharmacological effects. The domains of clinical pharmacopsychology encompass the clinical benefits of psychotropic drugs, the characteristics that predict responsiveness to treatment, the vulnerabilities induced by treatment (side effects, behavioural toxicity, iatrogenic comorbidity), and the interactions between drug treatment and psychological variables. The DSM-5 refers to a patient population that no longer exists: subjects who display various manifestations of psychological distress who do not receive any form of drug treatment for it. Any type of psychotropic drug treatment, particularly after long-term use, may increase the risk of experiencing additional psychopathological problems that do not necessarily subside with discontinuation of the drug. The changes may be persistent and not limited to a short phase, such as in the case of withdrawal reactions, and cannot be subsumed under the generic rubrics of adverse events or side effects.

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The General Neurotic Syndrome: A Re-Evaluation

Cited by 30 publications

References 36 publications

Clinical Pharmacopsychology: Conceptual Foundations and Emerging Tasks

Clinical Pharmacopsychology: Conceptual Foundations and Emerging Tasks

The Items Predicting Non-Remission after 6 Months of Treatment of Patients with Generalized Anxiety Disorder Covered the Eysenck Neuroticism Components of Anxiety, Interpersonal Sensitivity and Depression

What psychologists need to know about psychotropic medications

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