2015
DOI: 10.1016/j.tim.2014.12.006
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The general stress response in Alphaproteobacteria

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Cited by 68 publications
(85 citation statements)
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“…Although this integrated computational and experimental approach proved to be a useful tool to disentangle molecular interactions in the circadian signaling system of S. elongatus, its applicability is much broader. The ability to infer function partners in a complex signaling network can be of use for understanding the stress response of Alphaproteobacteria, where the role of HRXXN kinases and response regulators has not been fully characterized (38,39). Also, our framework might inform the study of organisms like myxobacteria, which have the largest number of TCS in any organism and a remarkably large number of unpaired TCS proteins (40).…”
Section: Resultsmentioning
confidence: 99%
“…Although this integrated computational and experimental approach proved to be a useful tool to disentangle molecular interactions in the circadian signaling system of S. elongatus, its applicability is much broader. The ability to infer function partners in a complex signaling network can be of use for understanding the stress response of Alphaproteobacteria, where the role of HRXXN kinases and response regulators has not been fully characterized (38,39). Also, our framework might inform the study of organisms like myxobacteria, which have the largest number of TCS in any organism and a remarkably large number of unpaired TCS proteins (40).…”
Section: Resultsmentioning
confidence: 99%
“…The general stress response in alpha-proteobacteria has been shown to involve a partner switching mechanism whereby an anti-sigma factor (termed NepR) either binds to an extracytoplasmic function (ECF) sigma factor (termed σ EcfG ) and inhibits σ EcfG activity or it binds to an anti-anti-sigma factor (termed PhyR), allowing σ EcfG to interact with the core RNA polymerase (see [5, 6] for review). The unique property of this GSR system that is not found in other bacteria outside of the alpha-proteobacteria is the incorporation of the ECF sigma factor with another gene regulatory mechanism, the two-component system (TCS).…”
Section: Introductionmentioning
confidence: 99%
“…However, the effector domain of PhyR cannot bind to DNA since it lacks the necessary residues for DNA-binding [8]. Instead PhyR regulates the activity of the NepR anti-sigma factor via protein-protein interaction [5]. The diverse environmental cues that determine if the GSR is activated include temperature, desiccation, oxidative, osmotic stress, acid stress, UV, ethanol, and hemin [814].…”
Section: Introductionmentioning
confidence: 99%
“…In alphaproteobacteria, a major function in the general stress response was assigned to the PhyR-NepR-EcfG cascade (35). None of the genes encoding homologs of PhyR, NepR, or RpoE2 (RSP_1274 to RSP_1272) showed growth-phase-dependent expression in our study (Table S1), and a PhyR mutant did not differ significantly in growth behavior from the wild type (data not shown).…”
Section: Resultsmentioning
confidence: 65%