The Generalised Mutation Theory of Oncogenesis

Knigavko, V.G.; Бондаренко, Марина Анатольевна; Zaytseva, Olga

doi:10.7860/jcdr/2018/36371.12236

Cited by 2 publications

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“…У нормальних клітинах після впливу малих доз виявлено стимуляцію ендогенної антиоксидантної системи репарації, а на рівні організму відповідь на дію малих доз радіації супроводжується і активацією імунної системи. Показано, що низькі дози радіації можуть стимулювати імунологічні реакції шляхом полегшення процесу передачі сигналу [23,[28][29][30][31][32][33][34].…”

Section: Eejp 2 (2021)unclassified

Modeling of Molecular Mechanisms of Radiation Adaptive Response Formation

2021

EEJP

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The phenomenon of adaptive response is expressed in the increase of resistance of a biological object to high doses of mutagens under the conditions of previous exposure to these (or other) mutagens in low doses. Low doses of mutagen activate a number of protective mechanisms in a living object, which are called hormetic. Thus, the adaptive response and hormesis are links in the same chain. Radiation hormesis refers to the generally positive effect of low doses of low LET radiation on biological objects. The phenomenology of radiation-induced adaptive response and radiation hormesis for biological objects of different levels of organization is considered; the review of existing theories describing the dose-effect relationship has been reviewed. The hypothesis proposing one of the mechanisms of formation of radiation adaptive response of cells taking into account the conformational structure of chromatin has been submitted. The analysis of modern concepts of the phenomenon of hormesis on the basis of modeling of molecular mechanisms of formation of hormetic reactions to low-dose low LET radiation has been carried out. The parameters that can be used for quantitative and graphical evaluation of the phenomenon of hormesis was considered, and a formula for calculating the coefficient of radiation-induced adaptive response has been proposed. A review of mathematical models describing the radiation relative risk of gene mutations and neoplastic transformations at low-dose irradiation of cohorts has been performed. The following conclusions have been made: radiation hormesis and adaptive response are generally recognized as real and reproducible biological phenomena, which should be considered as very important phenomena of evolutionarily formed biological protection of living organisms from ionizing radiation. The hormesis model of dose-response relationship makes much more accurate predictions of a living object's response to radiation (or other stressors) in the low-dose range than the linear threshold (LNT) model does. The LNT model can adequately describe reactions only in the region of high doses of radiation, and, therefore, extrapolation modeling of biological object’s reactions from the zone of high doses to low doses is not correct.

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