In the field of biomedical research, data characteristics often exhibit significant variability, challenging the applicability of classical probability distributions for biomedical data modeling. In this research, we introduce a novel four‐parameter distribution called the odd beta prime Kumaraswamy (OBPK) distribution, derived from the odd beta prime generalized family of distributions and the Kumaraswamy distribution. This distribution exhibits greater flexibility compared with the traditional Kumaraswamy distribution. Importantly, the OBPK distribution offers symmetrical, right‐skewed, left‐skewed, bathtub, N‐shaped, J‐shaped, and reversed J‐shaped densities, as well as varied hazard functions, including increasing, decreasing, bathtub, increasing‐decreasing, upside‐down bathtub, and N‐shaped forms. These curvature patterns make it particularly useful for modeling biomedical data. We derive some basic properties of the OBPK distribution. Parameters are estimated using the maximum likelihood approach, and the performance of various estimators is assessed via Monte Carlo simulations. Finally, four applications to real data on COVID‐19 mortality rates from different countries are evaluated to demonstrate the importance of the OBPK model over other extended versions of the Kumaraswamy models. The empirical findings suggest that the OBPK model outperforms other extended versions of the Kumaraswamy models in these applications.