12 Mpix color commercial-of-the-shelf (COTS) image sensor from CMOSIS was tested with proton radiation. The target mission required an irradiation with protons of energy of 50 MeV and fluences up to 1·10 12 p/cm 2 . Several intermediate steps were introduced to check the behavior of the image sensor. A low-cost test camera was developed to control the image sensors, acquire the images, and monitor the currents and voltages during the tests. Each color was characterized separately according to the EMVA 1288 standard. Such treatment allowed also analysis of the bayer filter deposited on the image sensor surface. Post-radiation characterization revealed that a significant deterioration in the parameter performance was found independently of the pixel color. The most affected parameters were dark current and dark signal nonuniformities (DSNU) which have increased from about one to two orders of magnitude.