The genesis of adenolymphoma

Azzopardi, J. G.; Tsün, Hou Lee

doi:10.1002/path.1700880127

Cited by 87 publications

(29 citation statements)

References 8 publications

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“…We also believe, however, that most cases, particularly in the parotid area, do arise from salivary duct inclusions within lymph nodes and that the theories are not mutually exclusive. Such an origin has been convincingly demonstrated by Azzopardi and Hou (1964). We agree with Evans and Cruickshank (1970) that these small, non- encapsulated lesions may well represent focal hyperplasia of duct epithelium rather than true neoplasms and would regard the term 'oncocytic adenomatous hyperplasia' (Kleinsasser et al, 1966) as appropriate.…”

Section: Discussionsupporting

confidence: 83%

Papillary tumours of the minor salivary glands.

Whittaker¹,

Turner²

1976

J Clin Pathol

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The clinical and histological features of oncocytic adenomatous hyperplasia, papillary adenoma, and papillary adenocarcinoma of the oral cavity are described, and the literature is reviewed. Histological features which may be of value in distinguishing between benign and malignant variants are described, and in view of the slow growth rate of most of these tumours, the importance of long-term follow-up is stressed.

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Section: Discussionsupporting

confidence: 83%

Papillary tumours of the minor salivary glands.

Whittaker¹,

Turner²

1976

J Clin Pathol

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“…Two of the cases originally described in lymph nodes [5] were also studied at postmortem (after 8 and 25 months, respectively) and in none of them a primary tumor was found. The case of MCC reported by Fornelli et al [7] was found within an adenolymphoma of parotid, a benign tumor that often recognizes a primary origin in lymph nodes [1]. If MCCs of the skin are believed to be related to Merkel cells [9,19] that harbor along the basal layer of epidermis, the origin of MCC of salivary glands, breast, genital tract, and lymph nodes from Merkel cells is highly questionable, as no native Merkel cells are present in these organs.…”

Section: Discussionmentioning

confidence: 97%

Trisomy of chromosome 6 in Merkel cell carcinoma within lymph nodes

et al. 2008

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Merkel cell carcinoma (MCC) of the skin is a neuroendocrine tumor with characteristic histological and immunohistochemical features. Among various cytogenetic changes, trisomy of chromosome 6 has been reported in 47% of cases using in situ hybridization. Primary tumors, morphologically and immunohistochemically identical to MCCs of the skin, have been described in other organs, including lymph nodes. Here, a cytogenetic study of four cases of MCC of lymph nodes is presented. Four cases of primary MCCs of lymph nodes and ten cases of cutaneous MCCs were studied for chromosome 6 using fluorescent in situ hybridization (FISH). All cases showed typical features of MCC both at hematoxylin and eosin (H&E) and immunohistochemistry. FISH showed trisomy 6 in two out of the four cases ofMCCs of lymph node as well as in 6 out 10 cases of MCCs of skin. Lymph nodal and cutaneous MCCs share same histological and immunohistochemical features, as well as same cytogenetic alteration for chromosome 6. It seems that there are more similarities than differences between cutaneous and lymph nodal MCCs. Whether lymph nodal MCCs are primary tumors or metastases from regressed skin lesions is still questionable, although several findings indicate a primary origin.

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“…Unequivocal evidence for this pathogenesis was provided by Azzopardi 15 The submaxillary and sublingual glands develop as compact entities and encapsulation occurs early, preventing the mixing of salivary and lymphoid tissue. Thus Warthin's tumor originates exclusively from the parotid gland or its immediate environs.…”

Section: Discussionmentioning

confidence: 97%

Warthin's Tumor, a Multifocal Disease

Shugar¹,

Som²,

Biller³

1982

Ann Otol Rhinol Laryngol

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Of all salivary gland neoplasms Warthin's tumor is the only lesion which is truly multicentric. The most common presentation of these multiple lesions is bilateral solitary masses. We present the first reported case of bilateral multiple tumors occurring simultaneously. The embryology of the salivary glands as it relates to the pathogenesis of this tumor is discussed. The differential diagnosis of the multinodular parotid gland is reviewed.

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The genesis of adenolymphoma

Cited by 87 publications

References 8 publications

Papillary tumours of the minor salivary glands.

Papillary tumours of the minor salivary glands.

Trisomy of chromosome 6 in Merkel cell carcinoma within lymph nodes

Warthin's Tumor, a Multifocal Disease

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