The GENESIS Project (GENeralized Early Sepsis Intervention Strategies)

Cannon, Chad; Holthaus, Christopher V.; Zubrow, Marc T.; Posa, Pat; Gunaga, Satheesh; Kella, V.; Elkin, Ron; Davis, Scott; Turman, Bonnie; Weingarten, Jordan S.; Milling, Truman J.; Lidsky, Nathan; Coba, Victor; Suarez, Arturo; Yang, James; Rivers, Emanuel P.

doi:10.1177/0885066612453025

Cited by 51 publications

(26 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, a higher concentration of biomarkers has been considered to have prognostic significance, as indicative of greater activation of the inflammatory and vasoactive systems [22,23,39]. However, implementing those measures indicated in the Surviving Sepsis Campaign [29], especially early surgical treatment if indicated, immediate antibiotic therapy, adequate and timely volume restitution, and initiating catecholamine treatment, the clinical course of patients could be better and, at least in part, independent of baseline characteristics [57,58]. In fact, the unique factor associated with survival was the significant decrease in the serum concentration of PCT.…”

Section: Discussionmentioning

confidence: 99%

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Ríos-Toro¹,

Márquez-Coello

García-Álvarez³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

BackgroundThe objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU).MethodsFifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied. SOFA and APACHE II scores as well as serum biomarkers were measured at days 0, 2 and 5. The influence of these variables on 28-day mortality was analyzed. Twenty healthy individuals served as controls.ResultsBaseline serum concentrations of sTREM-1, sCD163, IL-6 and PCT correlated with SOFA score. Only sTREM-1 levels correlated with APACHE II score. The 28-day mortality rate for all patients was 42%. The absence of risk factors for infection, presence of septic shock, baseline values of sCD14 and decrease of PCT and IL-6 from baseline to day 5 were variables associated to mortality in the univariate analysis. The unique independent factor associated to mortality in the multivariate analysis was a decrease of PCT higher than 50% from days 0 to 5.ConclusionsSerum levels of sTREM-1 are correlated with the severity of sepsis. A 50% decrease of PCT was the unique variable associated with survival in the multivariate analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Ríos-Toro¹,

Márquez-Coello

García-Álvarez³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…12 In addition, a multi-center study of 2,424 septic shock patients by Cannonet al found that 37.6% patients had alactatemia. 13 The cause of alactatemia remains unclear. In our subjects, no well-defined differences in characteristics were observed between the alactatemia and hyperlactatemia groups ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Lactate profiles of pediatric shock patients in Cipto Mangunkusumo General Hospital 2015: a pilot study

Yuniar

2017

View full text Add to dashboard Cite

Background The 2015 Surviving Sepsis Campaign (SSC) guidelines for management of shock recommend blood lactate to assess the success of resuscitation in shock. However, a study in adults found that 1/3 of septic shock patients had normal lactate levels (alactatemia) and lower mortality rates. Objective To evaluate lactate profiles, possible factors affecting lactate levels, and mortality outcomes in pediatric shock patients in the emergency room (ER) and pediatric intensive care unit (PICU). Methods This was a retrospective study on pediatric shock patients aged 1 month to 18 years in the ER or PICU from June 2014 to December 2015. Data were taken from subjects' medical records including lactate levels, examination data required to calculate a PELOD score, and mortality outcomes. Results Of 223 shock patients evaluated, only 92 cases (41.2%) underwent lactate examinations. Of these, 59 (64.1%) had alactatemia and 33 (35.9%) had hyperlactatemia. A total of 23.7% of the alactatemia group and 36.4% of the hyperlactatemia group died, thus, the initial lactate level was not significantly associated with patient outcomes (P=0.197). The mortality rates of patients with <10% and ≥10% lactate clearance were 31.3% and 17.6%, respectively (P=0.362). Conclusion In alactatemia patients, lactate level can not be used as a goal for resuscitation. Further study is needed to find a biomarker for assessing the success of pediatric shock resuscitation. Moreover, the clinical relevance of alactatemia is uncertain in pediatric shock patients

show abstract

“…Multiple clinical trials aimed at curbing the host inflammatory response to severe infection have yielded limited clinical success [3]. The mainstay of therapy for sepsis and septic shock remains 2-fold: (1) rapid treatment of the underlying infection and (2) early resuscitation to blunt physiologic abnormalities that potentiate disease progression [4]. The nature of these beneficial interventions focuses attention on rigorously defining the inciting insult caused by the pathogen.…”

Section: Inflammation: An Early S Aureus Insult In Sepsismentioning

confidence: 99%

Igniting the Fire: Staphylococcus aureus Virulence Factors in the Pathogenesis of Sepsis

2014

View full text Add to dashboard Cite

The GENESIS Project (GENeralized Early Sepsis Intervention Strategies)

Cited by 51 publications

References 43 publications

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Lactate profiles of pediatric shock patients in Cipto Mangunkusumo General Hospital 2015: a pilot study

Igniting the Fire: Staphylococcus aureus Virulence Factors in the Pathogenesis of Sepsis

Contact Info

Product

Resources

About