The Genetic Analysis of Oogenesis in Drosophila melanogaster

King, Robert C.; Mohler, Jym

doi:10.1007/978-1-4615-7145-2_29

Cited by 26 publications

(35 citation statements)

References 49 publications

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“…Applied at the end of oogenesis, they cause a decrease in SF female sterility and applied at earlier stages of oogenesis on the contrary, they reinforce sterility. In these experiments, the number of eggs laid by the SF females was not determined, which makes it impossible to define exactly which of the various stages of oogenesis described by King et al (1956) are heat sensitive. However, data obtained with flies raised at 20°C (Bregliano, 1970) and 25°C (King,l957) suggest that the period during which the heat treatment has a curative effect on sterility is located during vitellogenesis.…”

Section: Resultsmentioning

confidence: 99%

Non-mendelian female sterility in Drosophila melanogaster: influence of ageing and thermic treatments

Bucheton

1978

Heredity

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SUMMARYCrosses between certain Drosophila melanogaster strains may give rise to female sterility of non-Mendelian determination. Reduced fertility is observed in Fl females, known as SF females, from crosses between females of " reactive" strains and males of "inducer" strains. The extent of this reduction of fertility depends on the strains which are used in the cross and on two nongenetic factors: age and temperature. The fertility of SF females increases with ageing. Also, exposing them for a short period to a high temperature (29°C) either increases or decreases the probability of hatching of the eggs according to the stage of oogenesis at which the heat treatment is applied. A very striking point is that qualitatively quite similar, though attenuated, effects are observed when the two factors (ageing and temperature) are applied not directly to SF females, but to their maternal ancestors: mothers and grandmothers.

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Section: Resultsmentioning

confidence: 99%

Non-mendelian female sterility in Drosophila melanogaster: influence of ageing and thermic treatments

Bucheton

1978

Heredity

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“…1B). As cysts continue to grow and mature, they leave the germarium and move into the 'vitellarium' (King et al, 1956). The oocyte remains in pachytene with full-length SC until vitellarial stage 6 (Carpenter, 1975;Page and Hawley, 2001); however, the remaining 15 cells within each cyst adopt a nurse cell fate and enter an endo cell cycle, during which multiple rounds of S phase in the absence of intervening M phase results in polyploid cells (Dej and Spradling, 1999).…”

Section: Introductionmentioning

confidence: 99%

Regulation of meiotic cohesion and chromosome core morphogenesis during pachytene inDrosophilaoocytes

Khetani

Bickel

2007

Journal of Cell Science

134

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During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila, null mutations in the ord gene abolish meiotic cohesion, although how ORD protein promotes cohesion has remained elusive. We show that SMC subunits of the cohesin complex colocalize with ORD at centromeres of ovarian germ-line cells. In addition, cohesin SMCs and ORD are visible along the length of meiotic chromosomes during pachytene and remain associated with chromosome cores following DNase I digestion. In flies lacking ORD activity, cohesin SMCs fail to accumulate at oocyte centromeres. Although SMC1 and SMC3 localization along chromosome cores appears normal during early pachytene in ord mutant oocytes, the cores disassemble as meiosis progresses. These data suggest that cohesin loading and/or accumulation at centromeres versus arms is under differential control during Drosophila meiosis. Our experiments also reveal that the α-kleisin C(2)M is required for the assembly of chromosome cores during pachytene but is not involved in recruitment of cohesin SMCs to the centromeres. We present a model for how chromosome cores are assembled during Drosophila meiosis and the role of ORD in meiotic cohesion, chromosome core maintenance and homologous recombination.

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“…Newly eclosed D. melanogaster females have previtellogenic ovaries; this means that the yolk proteins are not yet deposited in the oocytes (King et at., 1956). Thus, the ovarian immaturity normally present in newly eclosed flies is maintained in diapausing flies.…”

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Diapause in Drosophila melanogaster females: a genetic analysis

Williams

Sokolowski

1993

Heredity

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Female Drosophila melanogaster exhibit ovarian diapause at low temperatures and short day lengths. We found that D. melanogaster isofemale lines from Windsor (Ontario, Canada) had a significantly higher percentage of females in diapause than did those from Cartersville (Georgia, U.S.A.). To investigate the heredity of this trait, we performed a 16-reciprocal cross analysis using two extreme isofemale lines called W and C. We found that diapause in D. melanogaster is inherited as a simple autosomal recessive trait with the C response (less flies in diapause) completely dominant to the W one. Maternal and cytoplasmic factors did not affect differences in diapause in these lines. The result of our genetic analysis of diapause in D. melanogaster opens many avenues for the genetic dissection of this ecologically relevant trait.

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The Genetic Analysis of Oogenesis in Drosophila melanogaster

Cited by 26 publications

References 49 publications

Non-mendelian female sterility in Drosophila melanogaster: influence of ageing and thermic treatments

Non-mendelian female sterility in Drosophila melanogaster: influence of ageing and thermic treatments

Regulation of meiotic cohesion and chromosome core morphogenesis during pachytene inDrosophilaoocytes

Diapause in Drosophila melanogaster females: a genetic analysis

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