The Genetic and Environmental Effects on Depressive Symptoms Among Older Female Twins

Takkinen, Sanna; Tolvanen, Asko; Kaprio, Jaakko; Berg, Stig; Koskenvuo, Markku; Rantanen, Taina

doi:10.1375/1369052042663904

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…Heritability for participation in physical activity is relatively high (Bouchard et al, 1992;Kujala et al, 2002) while for depression it is low to moderate (Burton et al, 2015;Kendler et al, 2006;Takkinen et al, 2004). Therefore, an association between physical activity and depression may be mediated in part by genetic factors common to both.…”

Section: Introductionmentioning

confidence: 99%

Persistent leisure-time physical activity in adulthood and use of antidepressants: A follow-up study among twins

Waller

Kaprio

Korhonen

et al. 2016

Journal of Affective Disorders

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Section: Introductionmentioning

confidence: 99%

Persistent leisure-time physical activity in adulthood and use of antidepressants: A follow-up study among twins

Waller

Kaprio

Korhonen

et al. 2016

Journal of Affective Disorders

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“…For example, a study of 343 pairs of young adult twins reported that the factors reflecting physiological functions (e.g., loss of appetite) or cognitions (e.g., feeling of hopelessness) had a significant heritable basis, whereas negative affect symptoms were not heritable (Jang, Livesley, Taylor, Stein, & Moon, 2004). In another study with 217 pairs of twins aged 64-76 years, Takkinen et al (2004) found that three subscales of the Center for Epidemiologic Studies Depression Scale (CES-D; i.e., depressed mood, psychomotor retardation, interpersonal difficulties) were mainly affected by environmental factors and that only the subscale of lack of well-being had a moderate genetic basis. These preliminary findings suggested that symptom dimensions of depression may be differentially susceptible to genetic and environmental factors.…”

mentioning

confidence: 99%

Etiological heterogeneity of symptom dimensions of adolescent depression

Chen

Zhang

et al. 2014

PsyCh Journal

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The aim was to investigate the underlying factor structure of adolescent depression and etiological heterogeneity in the symptom dimensions of adolescent depression. The sample included 842 pairs of same-sex adolescent twins, among which 613 pairs were monozygotic twins and 229 pairs were dizygotic twins. The ages of the participants ranged from 11 to 17 years (M = 13.64, SD = 1.80). Adolescents' depressive symptoms were assessed using the self-reported Children's Depression Inventory. Exploratory and confirmatory factor analyses were used to explore the factor structure of youth depression and twin genetic analyses were employed to estimate genetic and environmental influences on the derived dimensions. Results showed that adolescent depression encompassed five correlated dimensions: dysphoria mood, somatic symptoms, study and externalizing problems, anhedonia symptoms, and cognitive symptoms. These five symptom dimensions had heterogeneous etiologies: Dysphoria mood, somatic symptoms, and cognitive symptoms were moderately heritable (heritability ranged from 33 to 40%), whereas study and externalizing problems, and anhedonia symptoms were mainly environmentally influenced with minimal genetic basis. Our findings supported the multidimensionality of adolescent depression and the etiological heterogeneity of these symptom dimensions.

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“…Previous publications from SATSA (Gatz et al, 1992), LSADT (McGue & Christensen, 1997), MADT (Johnson et al, 2002), VETSA (Franz et al, 2011), and FTC (Takkinen et al, 2004; Korhonen et al, 2007) have presented results from behavior genetic analyses of depressive symptoms. The benefits of the IGEMS consortium are a large sample of twins offering increased power to detect potentially small moderation effects of physical illness, age, and sex and inclusion of a large number of opposite-sex twin pairs to explore potential sex differences in genetic and environmental influences on depressive symptoms.…”

Section: Methodsmentioning

confidence: 99%

Gene–environment interplay in depressive symptoms: moderation by age, sex, and physical illness

et al. 2017

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Background Numerous factors influence late-life depressive symptoms in adults, many not thoroughly characterized. We addressed whether genetic and environmental influences on depressive symptoms differed by age, sex, and physical illness. Methods The analysis sample included 24,436 twins aged 40 through 90 drawn from the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium. Biometric analyses tested age, sex, and physical illness moderation of genetic and environmental variance in depressive symptoms. Results Women reported greater depressive symptoms than men. After age 60, there was an accelerating increase in depressive symptom scores with age, but this did not appreciably affect genetic and environmental variances. Overlap in genetic influences between physical illness and depressive symptoms was greater in men than in women. Additionally, in men extent of overlap was greater with worse physical illness (the genetic correlation ranged from near .00 for the least physical illness to nearly .60 with physical illness two SD above the mean). For men and women, the same environmental factors that influenced depressive symptoms also influenced physical illness. Conclusions Findings suggested that genetic factors play a larger part in the association between depressive symptoms and physical illness for men than for women. For both sexes, across all ages, physical illness may similarly trigger social and health limitations that contribute to depressive symptoms.

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The Genetic and Environmental Effects on Depressive Symptoms Among Older Female Twins

Cited by 5 publications

References 57 publications

Persistent leisure-time physical activity in adulthood and use of antidepressants: A follow-up study among twins

Persistent leisure-time physical activity in adulthood and use of antidepressants: A follow-up study among twins

Etiological heterogeneity of symptom dimensions of adolescent depression

Gene–environment interplay in depressive symptoms: moderation by age, sex, and physical illness

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