1996
DOI: 10.1093/mutage/11.5.445
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The genetic and non-genetic toxicity of the fungicide Vinclozolin

Abstract: The mutagenic/cocarcinogenic potential of the fungicide Vinclozolin was assessed by a comprehensive examination of toxicity mechanisms at both the genetic and the metabolic level. Vinclozolin did not induce any significant increase in chromosomal aberrations in human pheripheral blood lymphocytes cultured in vitro, both in the presence and in the absence of metabolic activation. However, significant dose-related increases in micronucleated erythrocytes (up to 4-fold over the control) were found in the bone mar… Show more

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Cited by 40 publications
(22 citation statements)
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“…This distinction was not as robust between rat germ cells (sperm) and somatic cells (kidney). These data confirm previous reports that vinclozolin is not directly mutagenic [37], and suggest that neither the immediate phenotypic abnormalities observed in vinclozolin-lineage F1 generation offspring nor the transmission of those defects to the F2 generation can be ascribed to the direct induction of genetic mutations.…”
Section: Resultssupporting
confidence: 91%
“…This distinction was not as robust between rat germ cells (sperm) and somatic cells (kidney). These data confirm previous reports that vinclozolin is not directly mutagenic [37], and suggest that neither the immediate phenotypic abnormalities observed in vinclozolin-lineage F1 generation offspring nor the transmission of those defects to the F2 generation can be ascribed to the direct induction of genetic mutations.…”
Section: Resultssupporting
confidence: 91%
“…Fungicide residues have been found on food for human consumption, mostly from postharvest treatments (Brooks & Roberts, 1999). Some fungicides are dangerous to human health, such as vinclozolin, which has now been removed from use (Hrelia, 1996), FCX and DFB that are used as pesticides to control pests and they have many side effects on natural non-target organisms (Rouabhi et al, 2009). In this chapter, we will develop the fungicides and their toxicity on biological and ecological systems.…”
Section: Introductionmentioning
confidence: 99%
“…Fungicides have been found to adversely affect invertebrates like C. elegens (Jones et al 1996) and vertebrates like human beings (Hrelia et al 1996). Mathew and Al-Doori (1976) have shown mutagenic effects of mercuric fungicides that lead to sex-linked recessive lethal mutations.…”
Section: Introductionmentioning
confidence: 99%