The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery

Chan, Weilin; Wiggs, Janey L.; Sobrin, Lucia

doi:10.1016/j.ajo.2019.02.001

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…SIG shares characteristics with primary open-angle glaucoma (POAG). In fact, patients with POAG or susceptible to glaucoma (Fini et al., 2017 ), as well as their descendants, have a greater corticosteroid response, and a correlation has been demonstrated between the response to corticosteroids and the risk of developing glaucoma over time (Chan et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

et al. 2021

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“…One of the most shared hypotheses attributed the IOP elevation to a reduced aqueous outflow caused by reduced activity of the trabecular meshwork and extracellular debris accumulations (18)(19)(20)(21)(22). However, many other metabolic pathways have been involved in the pathogenesis of corticosteroids induced glaucoma (23), including also genetic predisposition (24), thus making this complication a multifactorial phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Intraocular Pressure Changes Are Predictive of Ocular Hypertension Onset After Fluocinolone Acetonide Implant: Significant Cutoffs and the Role of Previous DEX Implant

et al. 2021

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Background: Fluocinolone acetonide (FAc) implant represents a long-term strategy for the management of diabetic macular edema (DME). Because of the 3-year duration, the careful monitoring of the intraocular pressure (IOP) is necessary. The main aim of the study was to provide quantitative IOP cutoffs associated with the onset of IOP increases.Methods: The study was retrospectively conducted with 2-year of follow-up. We separately considered eyes with good IOP control (Group 1), eyes requiring IOP-lowering medications (Group 2) and eyes undergoing IOP-lowering surgery (Group 3). The statistical analysis assessed Delta% IOP changes over the 2-year follow-up. ROC analysis was performed to detect significant cutoffs associated with Group 2 and Group 3. IOP changes occurring after a previously administered dexamethasone (DEX) implant were also evaluated.Results: We included 48 eyes (48 patients), stratified as follows: Group 1 (25/48; 52%), Group 2 (19/48; 40%) and Group 3 (4/48; 8%). ROC analysis performed on IOP values detected 2-months later DEX implant showed a mean Delta IOP increase>24% significantly associated with IOP-lowering medications after FAc implant, whereas a mean Delta IOP increase>35% was significantly associated with IOP-lowering surgery after FAc implant. With respect to IOP changes occurred after FAc implant, our ROC analysis showed a mean Delta IOP increase>8% significantly associated with IOP-lowering medications, whereas a mean Delta IOP increase>15% was significantly associated with IOP-lowering surgery. DEX-related IOP changes showed 52% sensitivity and 100% specificity of FAc-related IOP increases.Conclusions: IOP changes provides clinically relevant cutoffs associated with the onset of FAc-related IOP increases.

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“…An estimated one-third of the population is moderately steroid responsive (rise of IOP 6-15 mmHg from baseline with steroid treatment), while 4-6% of the population is highly steroid responsive (IOP increase of >15 mmHg from baseline or IOP over 31 mmHg after steroid exposure). 116 Studies have found an increased risk of steroid-induced glaucoma among first-degree relatives of affected individuals, and in those with a personal or family history of POAG, suggesting that genetic factors may contribute to steroid response. 116 At the time of this review, no genetic associations have been identified for steroid-induced glaucoma, though GWASs are currently underway and will likely identify genetic contributors for this form of glaucoma in the near future.…”

Section: Steroid-induced Glaucomamentioning

confidence: 99%

“…116 Studies have found an increased risk of steroid-induced glaucoma among first-degree relatives of affected individuals, and in those with a personal or family history of POAG, suggesting that genetic factors may contribute to steroid response. 116 At the time of this review, no genetic associations have been identified for steroid-induced glaucoma, though GWASs are currently underway and will likely identify genetic contributors for this form of glaucoma in the near future.…”

Section: Steroid-induced Glaucomamentioning

confidence: 99%

The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities‐A review

Aboobakar

Wiggs

2022

Clinical Exper Ophthalmology

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Glaucoma refers to a heterogenous group of disorders characterised by progressive loss of retinal ganglion cells and associated visual field loss. Both early-onset and adult-onset forms of the disease have a strong genetic component. Here, we summarise the known genetic associations for various forms of glaucoma and the possible functional roles for these genes in disease pathogenesis. We also discuss efforts to translate genetic knowledge into clinical practice, including gene-based tests for disease diagnosis and risk-stratification as well as gene-based therapies.

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The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery

Cited by 13 publications

References 30 publications

Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres

Intraocular Pressure Changes Are Predictive of Ocular Hypertension Onset After Fluocinolone Acetonide Implant: Significant Cutoffs and the Role of Previous DEX Implant

The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities‐A review

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