The Genetic Polymorphisms in Colon Cancer

Nakashidze, Irina; Dariya, Begum; Peshkova, Tamar; Beridze, Sophio

doi:10.1615/critrevoncog.2020035957

Cited by 5 publications

(2 citation statements)

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“…Colon cancer (CC) is the leading cause of cancer-related mortality worldwide, and it’s one of the common digestive system tumors [ 1 ]. Treatment options for CC include surgical tumor removal, chemotherapy, radiation therapy, and others [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer

Tang,

Sang,

Gao

et al. 2024

Aging

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Background: Colon cancer (CC) is the most frequently occurring digestive system malignancy and is associated with a dismal prognosis. While super-enhancer (SE) genes have been identified as prognostic markers in several cancers, their potential as practical prognostic markers for CC patients remains unexplored. Methods: We obtained super-enhancer-related genes (SERGs) from the Human Super-Enhancer Database (SEdb). Transcriptome and relevant clinical data for colon cancer (CC) were sourced from the Gene Expression Omnibus (GEO) database. Subsequently, we identified up-regulated SERGs by the Weighted Gene Coexpression Network Analysis (WGCNA). Prognostic signatures were constructed via univariate and multivariate Cox regression analysis. We then delved into the mechanisms of these predictive genes by examining immune infiltration. We also assessed differential sensitivities to chemotherapeutic drugs between high-and low-SERGs risk patients. The critical gene was further validated using external datasets and finally confirmed by qRT PCR. Results: We established a ten-gene risk score prognostic model (S100A11, LZTS2, CYP2S1, ZNF552, PSMG1, GJC1, NXN, and DCBLD2), which can effectively predict patient survival rates. This model demonstrated effective prediction capabilities in survival rates at 1, 3, and 5 years and was successfully validated using external datasets. Furthermore, we detected significant differences in immune cell infiltration between highand low-SERGs risk groups. Notably, high-risk patients exhibited heightened sensitivity to four chemotherapeutic agents, suggesting potential benefits for precision therapy in CC patients. Finally, qRT-PCR validation revealed a significant upregulation of LZTS2 mRNA expression in CC cells. Conclusion: These findings reveal that the SERGs model could effectively predict the prognosis of CC.

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Section: Introductionmentioning

confidence: 99%

Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer

Tang,

Sang,

Gao

et al. 2024

Aging

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“…In general, oncological diseases are linked to numerous causative factors, including hormonal imbalance, the alteration of some cliniclaboratory characteristics genetics and environmental factors [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Altered Gene Expression and Epigenetic Mechanisms in Breast Cancer

Parveen Shaikh,

Murvanidze,

Shaikh

et al. 2023

J Biomed Res Environ Sci

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Among oncological diseases of women, breast cancer is a widespread disease. It should be noted that the disease is heterogeneous in many clinical and pathological features. The development of breast cancer is associated with many factors, and it is difficult to identify any specific risk factor. The studying the expression and epigenetic mechanisms of genes associated with breast cancer, it is possible to effectively combine epigenetic therapy with the existing one in clinical practice (chemotherapy, hormonal therapy, etc.) and accordingly, the treatment of disease is significantly improved.

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A functional variant rs10409772 in FUT6 promoter regulates colorectal cancer progression through PKA/CREB signaling

Zhang,

Song,

2024

Translational Oncology

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The Genetic Polymorphisms in Colon Cancer

Cited by 5 publications

References 0 publications

Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer

Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer

The Altered Gene Expression and Epigenetic Mechanisms in Breast Cancer

A functional variant rs10409772 in FUT6 promoter regulates colorectal cancer progression through PKA/CREB signaling

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