The genetic profile of bone marrow transplant patients in different samples of forensic interest

Forensic implications of the presence of chimerism after hematopoietic stem cell transplantation

“…After chimerism studies, a mixed profile has been found in nails, with amplification of both donor and recipient profile [32,33,34].…”

“…By using immunofluorescence techniques against cytokeratin and XY-FISH, they found epithelial donor-derived cells (XY-positives and cytokeratin-positive) in the layer of Malpighi of the skin [37]. Moreover, in 2018, Sanz-Piña et al obtained the genetic profile of epithelial cell samples isolated from cutaneous biopsies of allogeneic HSCT patients by the analysis of 15 STR markers, finding a mixed profile as well as a positive correlation, without statistical significance, between the time elapsed from the transplant to the biopsy and the percent donor chimerism in epithelial cells of the epidermis [34].…”