The Genetic Variations Associated With Time to Aseptic Loosening After Total Joint Arthroplasty

Kõks, S.; Wood, David; Reimann, Ene; Awiszus, Friedemann; Lohmann, Christoph H.; Bertrand, Jessica; Prans, Ele; Maasalu, Katre; Märtson, Aare

doi:10.1016/j.arth.2019.11.004

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…Several genetic variations of single-nucleotide polymorphisms (SNPs) are associated with an increased risk of aseptic loosening, as follows: IFIT2/IFIT3 (odds ratio = 21.6), CERK (odds ratio = 12.6) and PAPPA (odds ratio = 14) [45]. Another study supports the importance of genome impact on osteolysis susceptibility [46].…”

Section: Geneticsmentioning

confidence: 87%

How to Prevent Aseptic Loosening in Cementless Arthroplasty: A Review

et al. 2022

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Aseptic loosening is the main late postoperative complication of cementless total hip arthroplasties (THAs), leading to pain and functional impairment. This article aims to update the orthopedic surgeon on the various methods by which the aseptic loosening rate can be reduced. We performed a systematic review by searching the PubMed database for hip aseptic loosening. We included meta-analysis, randomized controlled trials, reviews, and systematic reviews in the last 10 years, which provided information on techniques that can prevent aseptic loosening in total hip arthroplasty. From a total of 3205 articles identified, 69 articles (2%) met the inclusion criteria, leading to a total of 36 recommendations. A lot of research has been conducted in terms of septic loosening in the last decade. Currently, we have various techniques by which we can reduce the rate of aseptic loosening. Nevertheless, further randomized clinical trials are needed to expand the recommendations for aseptic loosening prevention.

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Section: Geneticsmentioning

confidence: 87%

How to Prevent Aseptic Loosening in Cementless Arthroplasty: A Review

et al. 2022

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“…The probability of developing an osteolytic response is likely to involve the combination of environmental and genetic factors [18]. Environmental factors and genetic susceptibilities may trigger an immune response at the implant site, resulting in implant-induced osteolysis [19]. Environmental factors that can lead to aseptic loosening include implant material, component malalignment, high patient weight and activity, low bone quality, and relevant medical histories, such as diabetes and renal failure, with debris at the bone cement interface being one important factor [20].…”

Section: Discussionmentioning

confidence: 99%

Pressurized carbon dioxide lavage reduces the incidence of a radiolucent line around the tibial component two years after total knee arthroplasty

et al. 2022

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Introduction In cemented total knee arthroplasty (TKA), pressurized carbon dioxide (CO2) lavage prior to cement fixation can eliminate debris at the bone-cement interface and is considered effective for increasing cement penetration and preventing aseptic loosening. Regarding the risk of a preliminary diagnosis of implant loosening, a radiolucent line (RLL) is a valuable sign. The purpose of this study was to compare the incidence of a tibial RLL at 2 years after TKA with and without pressurized CO2 lavage. Methods This is a retrospective study. One hundred knees from 98 patients were enrolled in this study. TKA was performed without pressurized CO2 lavage (CO2− group) for the first 47 knees, and with pressurized CO2 lavage (CO2+ group) for the next 53 knees. The depth of cement penetration was measured just after surgery, and the incidence of tibial RLL > 2 mm at 2 years after TKA was determined. Results Significant differences between groups were not seen regarding pre- and postoperative clinical factors. The depth of cement penetration in each area was significantly higher in the CO2+ group. The frequency of knees with RLL > 2 mm was significantly lower in the CO2+ group than in the CO2− group (p < 0.001). Conclusions Pressurized CO2 lavage improved cement penetration and decreased the incidence of tibial RLL > 2 mm at 2 years after TKA.

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“…However, these compounds are biologically inert, and have poor bone conductivity. As a result, the stem of a Ti alloy artificial joint cannot form an osseous bond with bone tissue, and long-term use in the body will cause aseptic loosening [4][5][6]. In addition, under the wear and corrosion of the fretting environment in vivo, Ti alloy artificial joint stems are prone to producing wear debris and metal ions, leading to the expression of bone resorption in osteoclasts and shortening of service life [7,8].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Multilayer Ca/P Bio-Ceramic Coating by Laser Cladding

2021

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In order to enhance the bioactivity and wear resistance of titanium (Ti) and its alloy for use as an implant surface, a multilayer Ca/P (calcium/phosphorus) bio-ceramic coating on a Ti6Al4V alloy surface was designed and prepared by a laser cladding technique, using the mixture of hydroxyapatite (HA) powder and Ti powder as a cladding precursor. The main cladding process parameters were 400 W laser power, 3 mm/s scanning speed, 2 mm spot diameter and 30% lapping rate. When the Ca/P ceramic coating was immersed in simulated body fluid (SBF), ion exchange occurred between the coating and the immersion solution, and hydroxyapatite (HA) was induced and deposited on its surface, which indicated that the Ca/P bio-ceramic coating had good bioactivity. The volume wear of Ca/P ceramic coating was reduced by 43.2% compared with that of Ti6Al4V alloy by the pin-disc wear test, which indicated that the Ca/P bio-ceramic coating had better wear resistance.

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The Genetic Variations Associated With Time to Aseptic Loosening After Total Joint Arthroplasty

Cited by 13 publications

References 30 publications

How to Prevent Aseptic Loosening in Cementless Arthroplasty: A Review

How to Prevent Aseptic Loosening in Cementless Arthroplasty: A Review

Pressurized carbon dioxide lavage reduces the incidence of a radiolucent line around the tibial component two years after total knee arthroplasty

Preparation and Properties of Multilayer Ca/P Bio-Ceramic Coating by Laser Cladding

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