2024
DOI: 10.1146/annurev-genom-010423-095636
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The Genetics and Functional Genomics of Osteoarthritis

Ana Luiza Arruda,
Georgia Katsoula,
Shibo Chen
et al.

Abstract: Osteoarthritis is the most prevalent whole-joint degenerative disorder, and is characterized by the degradation of articular cartilage and the underlying bone structures. Almost 600 million people are affected by osteoarthritis worldwide. No curative treatments are available, and management strategies focus mostly on pain relief. Here, we provide a comprehensive overview of the available human genetic and functional genomics studies for osteoarthritis to date and delineate how these studies have helped shed li… Show more

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