The Genetics and Genomics of Virus Resistance in Maize

Abstract

Viruses cause significant diseases on maize worldwide. Intensive agronomic practices, changes in vector distribution, and the introduction of vectors and viruses into new areas can result in emerging disease problems. Because deployment of resistant hybrids and cultivars is considered to be both economically viable and environmentally sustainable, genes and quantitative trait loci for most economically important virus diseases have been identified. Examination of multiple studies indicates the importance of regions of maize chromosomes 2, 3, 6, and 10 in virus resistance. An understanding of the molecular basis of virus resistance in maize is beginning to emerge, and two genes conferring resistance to sugarcane mosaic virus, Scmv1 and Scmv2, have been cloned and characterized. Recent studies provide hints of other pathways and genes critical to virus resistance in maize, but further work is required to determine the roles of these in virus susceptibility and resistance. This research will be facilitated by rapidly advancing technologies for functional analysis of genes in maize.

Genome‐wide association study of resistance to Mal de Río Cuarto disease in maize

“…In adition, this cluster reported in bin 2.02 contains a major QTL resistant to Mal de Río Cuarto virus and/or Maize Rough Dwarf virus, which was patented by Martin et al (2010). On chromosome 6, Redinbaugh et al (2018) reported overlapping of loci conferring resistance to different viruses at 157 Mb. In a very close position, we identified a significant common genomic region for both traits and Rossi et al (2015) reported a QTL for SEV of MRC identified in a F 2:3 population.…”

“…Genes and genomic regions conferring resistance to various pathogens often reside in clusters (McMullen & Simcox 1995; Redinbaugh, Lübberstedt, Leng, & Xu, 2018). On bin 2.02, where a genomic region linked to both INC and SEV of MRC was mapped, three loci conferring resistance to three different viral diseases were previously identified (Dintinger et al., 2005; Jones et al., 2018; Luan, Wang, Li, Zhang, & Zhang, 2012).…”

“…On chromosome 6, Redinbaugh et al. (2018) reported overlapping of loci conferring resistance to different viruses at 157 Mb. In a very close position, we identified a significant common genomic region for both traits and Rossi et al.…”

Identifying inbred lines with resistance to endemic diseases in exotic maize germplasm

“…Using GWAS, we identified one region in bin 2.02 for DSI‐MRC that coincides with previously reported virus resistance QTL. Redinbaugh, Lübberstedt, Leng, and Xu (2018) reported QTL cluster for virus‐borne diseases in this bin. Specifically, the cluster reported in bin 2.02 contains a major QTL resistant to Mal de Rio Cuarto virus or Maize Rough Dwarf virus , which was patented by Martin et al.…”

Untitled

“…En el mismo bin, en nuestro trabajo identificamos un SNP asociado al ISE de la enfermedad. Redinbaugh et al (2018) combinaron resultados de estudios donde se identificaban QTL para resistencia a enfermedades virales en maíz e identificaron nueve regiones del genoma donde se agrupaban loci de resistencia (clusters). Uno de esos clusters se ubica en el bin 2.08 y reporta QTL de resistencia para tres enfermedades virales.…”