The genetics of anorexia nervosa collaborative study: Methods and sample description

Kaye, Walter H.; Bulik, Cynthia M.; Plotnicov, Katherine; Thornton, Laura M.; Devlin, Bernie; Fichter, Manfred M.; Treasure, Janet; Kaplan, Allan S.; Woodside, D. Blake; Johnson, Craig; Halmi, Katherine A.; Brandt, Harry; Crawford, Steve; Mitchell, James E.; Strober, Michael; Berrettini, Wade H.; Jones, Ian

doi:10.1002/eat.20509

Cited by 47 publications

(43 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second inclusion criterion required a lifetime DSM-IV-TR diagnosis of AN with or without amenorrhea, which resulted in the exclusion of four participants. The amenorrhea criterion was waived for this analysis to be consistent with recent literature in AN 11 and is based on the replicated observation that individuals with and without amenorrhea do not differ in meaningful ways. 12,13 The final inclusion criterion required complete discharge and year 1 follow-up information.…”

Section: Participantsmentioning

confidence: 96%

Rate of inpatient weight restoration predicts outcome in anorexia nervosa

Lund

Hernandez

Yates

et al. 2008

Intl J Eating Disorders

Self Cite

106

View full text Add to dashboard Cite

show abstract

Section: Participantsmentioning

confidence: 96%

Rate of inpatient weight restoration predicts outcome in anorexia nervosa

Lund

Hernandez

Yates

et al. 2008

Intl J Eating Disorders

Self Cite

106

View full text Add to dashboard Cite

show abstract

“…Despite the efforts of many [16, 20, 42, 53, 54], the community’s collective understanding of AN genetic susceptibility and its influence on prognosis remains limited. The phenotypic expression of a genotype is dependent on an array of host factors including genetic background, age and gender, developmental-, physiological- and pathological- conditions, as well as environmental factors such as dietary nutrition, exercise, and nicotine.…”

Section: Discussionmentioning

confidence: 99%

“…Polyunsaturated fatty acid and eicosanoid (metabolites) assays were performed using banked plasma from convenience samples [42, 43]. Whole blood was collected in EDTA vacutainer tubes and plasma was separated by centrifugation at 1350 rpm for 10 minutes and removed using pipet.…”

Section: Methodsmentioning

confidence: 99%

Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa

Shih

2017

Prostaglandins & Other Lipid Mediators

View full text Add to dashboard Cite

Background Anorexia nervosa (AN) is a serious mental illness characterized by emaciation, an intense fear of gaining weight despite being underweight, and distorted body image. Few treatments reverse the core symptoms in AN such as profound aversion to food and food avoidance. Consequently, AN has a chronic and relapsing course and the highest mortality rate of any psychiatric illness. A more complete understanding of the disease pathogenesis is needed in order to develop better treatments and improve AN outcome. The pathogenesis and psychopathophysiology of AN can be better elucidated by combining longitudinal phenotyping with multiple “omics” techniques, including exon sequencing, proteomics, lipidomic, and metabolomics. Design This paper summarizes the key findings of a series of interrelated studies including new experimental data and previously published data, and describes our current initiatives and future directions. Results Exon sequencing data was analyzed in 1205 AN and 1948 controls. Targeted metabolomics, lipidomics, and proteomics data were collected in two independent convenience samples consisting of 75 subjects with eating disorders and 61 age-matched healthy controls. Study participants were female and the mean age was 22.9 (4.9 [SD]) years. Epoxide hydrolase 2 (EPHX2) genetic variations were significantly associated with AN and that activity of epoxide hydrolase (sEH) was elevated in AN compared to controls. The polyunsaturated fatty acid (PUFA) and eicosanoids data revealed that Cytochromes P450 pathway was implicated in AN, and AN displayed a dysregulated postprandial metabolism of PUFAs and sEH-dependent eicosanoids. Implication and current Initiatives Collectively, our data suggest that dietary factors may contribute to the burden of EPHX2-associated AN susceptibility and affect disease outcome. We are implementing new investigations using a longitudinal study design in order to validate and develop an EPHX2 multi-omics biomarker system. We will test whether sEH-associated postprandial metabolism increases AN risk and affects treatment outcome through an ω-6 rich breakfast challenge. Participants will include 100 ill AN patients, 100 recovered AN patients, and 100 age- and race-matched healthy women. These data will allow us to investigate 1) how genetic and dietary factors independently and synergistically contribute to AN risk and progression, and 2) if clinical severity and treatment response in AN are affected by sEH activity and eicosanoid dysregulation. Results of our study will 1) identify clinically relevant biomarkers, 2) unravel mechanistic functions of sEH, and 3) delineate contributory roles of dietary PUFAs and Cytochrome P450 pathway eicosanoids for the purpose of developing novel AN treatments and improving disease prognosis.

show abstract

“…A detailed description of this investigation can be found elsewhere. (Kaye et al, 2008) This study was approved by local Institutional Review Boards and Ethics Boards. All participants provided informed consent prior to participation.…”

Section: Methodsmentioning

confidence: 99%

Primary Amenorrhea in Anorexia Nervosa: Impact on Characteristic Masculine and Feminine Traits

Baker¹,

Sisk

Thornton³

et al. 2013

Euro Eating Disorders Rev

Self Cite

View full text Add to dashboard Cite

Animal studies indicate gonadal hormones at puberty have an effect on the development of masculine and feminine traits. However, it is unknown whether similar processes occur in humans. We examined whether women with anorexia nervosa (AN), who often experience primary amenorrhea, exhibit attenuated feminization in their psychological characteristics in adulthood due to the decrease/absence of gonadal hormones at puberty. Women with AN were compared on a number of psychological characteristics using General Linear Models based on the presence/absence of primary amenorrhea. Although women with primary amenorrhea exhibited lower anxiety scores than those without primary amenorrhea, in general, results did not provide evidence of attenuated feminization in women with AN with primary amenorrhea. Future research should utilize novel techniques and direct hormone measurement to explore the effects of pubertal gonadal hormones on masculine and feminine traits.

show abstract

The genetics of anorexia nervosa collaborative study: Methods and sample description

Cited by 47 publications

References 80 publications

Rate of inpatient weight restoration predicts outcome in anorexia nervosa

Rate of inpatient weight restoration predicts outcome in anorexia nervosa

Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa

Primary Amenorrhea in Anorexia Nervosa: Impact on Characteristic Masculine and Feminine Traits

Contact Info

Product

Resources

About