The Genetics of Human Obesity

Bouchard, Claude; Pérusse, Louis

doi:10.1002/0470862092.d0502

Cited by 20 publications

(13 citation statements)

References 259 publications

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“…We know, for example, that genes can affect each component of energy balance 45 and can explain some of the differences between individuals in body weight and body composition. While we can conclude that our genes are permissive for weight gain, the gradual weight gain of the population does not seem to be primarily due to genetic factors.…”

Section: How Did the Epidemic Arise?mentioning

confidence: 99%

Obesity: Overview of an Epidemic

Mitchell

Catenacci

Wyatt

et al. 2011

Psychiatric Clinics of North America

411

295

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SYNOPSIS Despite growing recognition of the problem, the obesity epidemic continues in the U.S., and obesity rates are increasing around the world. The latest estimates are that approximately 34% of adults and 15–20% of children and adolescents in the U.S. are obese. Obesity affects every segment of the U.S. population. Obesity increases the risk of many chronic diseases in children and adults. The epidemic of obesity arose gradually over time, apparently from a small, consistent degree of positive energy balance. Substantial public health efforts are being directed toward addressing obesity, but there is not yet clear evidence of success. Because of the complexity of obesity, it is likely to be one of the most difficult public health issues our society has faced.

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Section: How Did the Epidemic Arise?mentioning

confidence: 99%

Obesity: Overview of an Epidemic

Mitchell

Catenacci

Wyatt

et al. 2011

Psychiatric Clinics of North America

411

295

View full text Add to dashboard Cite

show abstract

“…Since the first study from QFS showing that there was no evidence of association between the A, B and C loci of the HLA system and various body fatness and fat distribution traits [23], a good number of association and linkage studies have been undertaken using data from QFS. It is beyond the scope of this report to review all these findings but such reviews can be found elsewhere [24–26]. Since linkage studies require family data, the primary contribution of our cohort to the identification of genes related to obesity came from genome-wide linkage studies.…”

Section: Role Of Genetics In the Etiology Of Obesitymentioning

confidence: 99%

Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights

et al. 2014

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The Quebec Family Study (QFS) was an observational study with three cycles of data collection between 1979 and 2002 in Quebec City, Canada. The cohort is a mixture of random sampling and ascertainment through obese individuals. The study has significantly contributed to our understanding of the determinants of obesity and associated disease risk over the past 35 years. In particular, the QFS cohort was used to investigate the contribution of familial resemblance and genetic effects on body fatness and behaviors related to energy balance. Significant familial aggregation and genetic heritability were reported for total adiposity, fat-free mass, subcutaneous fat distribution, abdominal and visceral fat, resting metabolic rate, physical activity level and other behavioral traits. The resources of QFS were also used to study the contribution of several nontraditional (non-caloric) risk factors as predictors of excess body weight and gains in weight and adiposity over time, including low calcium and micronutrient intake, high disinhibition eating behavior trait, and short sleep duration. An important finding relates to the interactions between dietary macronutrient intake and exercise intensity on body mass and adiposity.Electronic supplementary materialThe online version of this article (doi:10.1007/s13679-013-0086-3) contains supplementary material, which is available to authorized users.

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“…According to the definition of the World Health Organization (WHO), approximately 6–10% of the population in Westernized countries is considered obese [3]. Epidemiological studies have shown that between 30–70% of the variation in body weight may be attributable to genetic factors [4]. Obesity related traits, such as body mass index (BMI), are influenced by both genetic and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…BMI is an easy, reliable, accurate measurement and is highly correlated (0.8–0.9) with total fat mass in adults [5]. A number of studies have estimated the heritability of BMI to be 40%-55% [4,6], but estimates greater than 80% have been found in twin studies.…”

Section: Introductionmentioning

confidence: 99%

Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study

et al. 2003

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Background: Genes have been found to influence the age of onset of several diseases and traits. The occurrence of many chronic diseases, obesity included, appears to be strongly age-dependent. However, an analysis of potential age of onset genes for obesity has yet to be reported. There are at least two analytic methods for determining an age of onset gene. The first is to consider a person affected if they possess the trait before a certain age (an early age of onset phenotype). The second is to define the phenotype based on the residual from a survival analysis.

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The Genetics of Human Obesity

Cited by 20 publications

References 259 publications

Obesity: Overview of an Epidemic

Obesity: Overview of an Epidemic

Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights

Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study

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