The Genetics of Obsessive–Compulsive Disorder

Grados, Marco A.; Dang, Rebecca

doi:10.1007/978-90-481-2298-1_9

Cited by 1 publication

(3 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Ru24969 Decreases Gaba Protein Expression In Micementioning

confidence: 99%

“…1.9 3 1.8 2,3 0.9 1 1.1 1,2 1.0 1 3.0 2 1.9 1,2 1.5 1,2 0.9 1 0.9 1 2.9 2 2.5 Figure 5: Water intake of mice in various groups included in the study (n = 6 mice/group). [1][2][3] Means within the same day with different numerical superscripts are significantly different (p < 0 05). Behavioural Neurology On the contrary, serotonin transporter levels did not show a discernible pattern with doses of RU24969 (Table 3).…”

Section: Ru24969 Decreases Gaba Protein Expression In Micementioning

confidence: 99%

“…Many studies provided strong evidence that the transmission of OCD is consistent with genetic transmission through specific brain chemical expression. These brain chemicals, such as serotonin, glutamate, and brain-derived neurotrophic factor, are involved in the severity of OCD symptoms [2][3][4][5]. Another factor, which is the environment, can affect the initiation and/or magnitude of OCD symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Establishing an OCD Model in BALB/c Mice Using RU24969: A Molecular and Behavioural Study of Optimal Dose Selection

Salloum,

Farran,

Shaib

et al. 2024

Behavioural Neurology

View full text Add to dashboard Cite

Obsessive-compulsive disorder (OCD) is a disabling disease characterized by distressing obsessions and repetitive compulsions. The etiology of OCD is poorly known, and mouse modeling allows to clarify the genetic and neurochemical basis of this disorder and to investigate potential treatments. This study evaluates the impact of the 5-HT1B agonist RU24969 on the induction of OCD-like behaviours in female BALB/c mice (n=30), distributed across five groups receiving varying doses of RU24969. Behavioural assessments, including marble test, tail suspension test, sucrose preference test, forced swim test, and nestlet shredding test, were conducted. Gene expression and protein quantitation of Gabra1 and serotonin transporter in mouse brain were also performed. Marble-burying behaviour increased significantly at high doses of RU24969 (15-20 mg/kg). The forced swimming test consistently showed elevated values at the same high concentrations, compared to the control. Altered reward-seeking behaviour was indicated by the sucrose preference test, notably at 15 and 20 mg/kg doses of RU24969. Nestlet shredding results did not show statistical significance among the tested animal groups. Gene expression analysis revealed reduced Gabra1 expression with increasing doses of RU, while serotonin transporter was not related to varying doses of RU24969. Western blotting corroborated these trends. The results underscore complex interactions between the serotonin system, GABAergic signaling, and OCD-relevant behaviours and suggest the use of intraperitoneal injection of 15 mg/kg of RU24969 to induce OCD-like behaviour in BALB/c mouse models.

show abstract