The genetics of Salmonella genomic island 1

Mulvey, Michael R.; Boyd, David A.; Olson, Adam B.; Doublet, Benoît; Cloeckaert, Axel

doi:10.1016/j.micinf.2005.12.028

Cited by 184 publications

(190 citation statements)

References 48 publications

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“…SGI1 carries resistance genes blaPSE-1, floR, aadA, sul, and tet encoding the resistance feature to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline, respectively (phenotype ACSSuT) [44]. In our study, the prevalence of ACSSuT in 1,4, [5],12:i:-, S. Typhimurium, and S. Choleraesuis was significantly higher than in S. Enteritidis; this is similar to findings in Shanghai [9].…”

Section: Discussionsupporting

confidence: 85%

Prevalence, resistance, and extended-spectrum beta-lactamases among Salmonella from patients in northeast China

Zhang¹,

Wang²,

Li³

et al. 2017

J Infect Dev Ctries

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Introduction: Salmonella is an important infection in Liaoning Province. Serotype and resistance levels are poorly studied. Knowledge of cephalosporin-resistant genes is needed to provide information to support the clinical diagnosis and to guide therapy. Methodology: A total of 172 isolates were collected from January 2009 to March 2014. Resistance to cephalosporin, fluoroquinolones, and other conventional first-line antibiotics was detected using the disk diffusion and agar dilution methods. The relatedness of isolates with the same serotype was analyzed by pulsed-field gel electrophoresis (PFGE). Genes encoding extended-spectrum β-lactamase enzymes (blaCTX-M, blaTEM, blaSHV, and blaOXA) were identified by polymerase chain reaction (PCR) and sequencing in cephalosporin-resistant strains. Results: S. Enteritidis, 1,4,[5],12:i:-, and S .Typhimurium were the most common serotypes. The resistance rate of Salmonella to conventional first-line antibiotics sulfamethoxazole-trimethoprim, tetracycline, chloramphenicol, and ampicillin was 21%,33%,37%, and 55%,respectively. To fluoroquinolones (gatixacin, levofloxacin, and ciprofloxacin), the resistance rates were 7%,18%, and 23%, respectively, whereas for extended-spectrum cephalosporins(ceftazidime, cefepime, and ceftriaxone), there sistance rates were 4%,8%, and 9%. In total, 14blaCTX-M, 14 blaTEM-1, and 1blaOXA-1 were found in 15 Salmonella isolates resistant to cephalosporin. No blaSHVwas detected. The blaCTX-M-55 gene was the most frequently encountered gene. The blaCTX-M-65 gene from S. Enteritidis is described for first time in Salmonella from humans. Results of PFGE indicated strong similarity among Salmonella isolates in Liaoning Province. Conclusions: Extended-spectrum cephalosporins are the first choice for the treatment of infection with Salmonella, but blaCTX-M-encoded resistance, including blaCTX-M-65, is present.

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Section: Discussionsupporting

confidence: 85%

Prevalence, resistance, and extended-spectrum beta-lactamases among Salmonella from patients in northeast China

Zhang¹,

Wang²,

Li³

et al. 2017

J Infect Dev Ctries

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“…Twelve of the SGI1-positive isolates were serovar Typhimurium, belonged to ST 19,and for a variant SGI1, which includes the integrons dfrA1/orfC and blaPSE1 (15). This result indicates chromosomal location of these integrons in these isolates.…”

Section: Integron Detection and Characterizationmentioning

confidence: 86%

“…However, antimicrobial drug resistance has become increasingly common in S. enterica, which can complicate therapy. The National Antimicrobial Resistance Monitoring System reported that in 2004, 15.0% of non-Typhi isolates were resistant to >2 classes of antimicrobial drugs, and 8.1% were resistant to >5 classes. The most common S. enterica multidrug-resistance pattern in 2004 was ACSSuT (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline) (5).…”

mentioning

confidence: 99%

“…An example of clonal expansion of integron bearing S. enterica is the global distribution of the serovar Typhimurium DT104 clone, which harbors a genetic resistance island known as the Salmonella genomic island 1 (SGI1). This region contains a number of drug resistance elements including 2 integrons with the gene cassettes blaPSE1 and aadA2 and genes for tetracycline and chloramphenicol resistance, which are not integron associated (15).…”

mentioning

confidence: 99%

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Integron-mediated Multidrug Resistance in a Global Collection of NontyphoidalSalmonellaentericaIsolates

Krauland

Marsh²,

Paterson³

et al. 2009

Emerg. Infect. Dis.

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“…The 5 resistance genes are found in a multidrug resistance (MDR) region that is located on the chromosome in a region termed Salmonella genomic island 1 (SGI1) (2). Recently, SGI1 has also been found in other Salmonella serovars (3), and several variants of the SGI1 MDR regions have been described (4).…”

mentioning

confidence: 99%

Variation in Antimicrobial Resistance in Sporadic and Outbreak-relatedSalmonella entericaSerovar Typhimurium

Nielsen¹,

Torpdahl²,

Ethelberg³

et al. 2009

Emerg. Infect. Dis.

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The prevalence of different antimicrobial resistance profiles and variants of the Salmonella genomic island 1 (SGI1) was reported for Salmonella enterica serovar Typhimurium DT104 strains isolated from patients in Denmark. Variation in antimicrobial resistance and corresponding changes of SGI1 were shown among isolates from a foodborne outbreak.

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The genetics of Salmonella genomic island 1

Cited by 184 publications

References 48 publications

Prevalence, resistance, and extended-spectrum beta-lactamases among Salmonella from patients in northeast China

Prevalence, resistance, and extended-spectrum beta-lactamases among Salmonella from patients in northeast China

Integron-mediated Multidrug Resistance in a Global Collection of NontyphoidalSalmonellaentericaIsolates

Variation in Antimicrobial Resistance in Sporadic and Outbreak-relatedSalmonella entericaSerovar Typhimurium

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