The Genetics of Seborrheic Dermatitis: A Candidate Gene Approach and Pilot Genome-Wide Association Study

Sanders, Martijn G H; Pardo, Luba M.; Uitterlinden, André G.; Smith, Adrian; Ginger, Rebecca S.; Nijsten, Tamar

doi:10.1016/j.jid.2017.11.020

Cited by 19 publications

(11 citation statements)

References 12 publications

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“…A special feature of seborrhoeic dermatitis is that it can be triggered by stress factors, nutrition, drugs and skin irritations. Beyond such triggers, a genetic disposition has been discussed . It can impact the quality of life of those with the disease, which includes discomfort, stigmatization, loss of self‐esteem and limitations in social activities …”

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confidence: 99%

Epidemiology and dermatological comorbidity of seborrhoeic dermatitis: population‐based study in 161 269 employees

et al. 2019

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Summary Background Seborrhoeic dermatitis is a common but epidemiologically poorly researched chronic skin disease. Objectives To characterize the prevalence and dermatological comorbidity of seborrhoeic dermatitis in Germany. Methods In the course of voluntary company skin checks, full‐body examinations were carried out in more than 500 companies by experienced dermatologists and documented electronically. Results In total, 161 269 participants were included (men 55·5%, mean age 43·2 ± 10·9 years). Seborrhoeic dermatitis was identified in 3·2% (men 4·6%, women 1·4%). A significant difference was found between age groups (2·0% in < 35; 3·6% in 35–64; 4·4% ≥ 65 years). The most frequent concomitant skin conditions were: folliculitis [17·0%, 95% confidence interval (CI) 15·9–18·1], onychomycosis (9·1%, 95% CI 8·3–10·0), tinea pedis (7·1%, 95% CI 6·3–7·8), rosacea (4·1%, 95% CI 3·6–4·7), acne (4·0%, 95% CI 3·4–4·5) and psoriasis (2·7%, 95% CI 2·3–3·2). Regression analysis revealed the following relative dermatological comorbidities when controlling for age and sex: folliculitis [odds ratio (OR) 2·1, 95% CI 2·0–2·3], contact dermatitis (OR 1·8, 95% CI 1·1–2·8), intertriginous dermatitis (OR 1·8, 95% CI 1·4–2·2), rosacea (OR 1·6, 95% CI 1·4–1·8), acne (OR 1·4, 95% CI 1·2–1·7), pyoderma (OR 1·4, 95% CI 1·1–1·8), tinea corporis (OR 1·4, 95% CI 1·0–2·0), pityriasis versicolor (OR 1·3, 95% CI 1·0–1·7) and psoriasis (OR 1·2, 95% CI 1·0–1·5). Conclusions Seborrhoeic dermatitis is a common disease, which is more prevalent in men and older people, and it has an increased rate of dermatological comorbidity. However, absolute differences in the prevalence of comorbidities are small and negligible. Nevertheless, the findings underline the need for integrated, complete dermatological diagnostics and therapy.

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confidence: 99%

Epidemiology and dermatological comorbidity of seborrhoeic dermatitis: population‐based study in 161 269 employees

et al. 2019

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“…PIRT is a modulator of TRPV1 (one of the regulators of itch) and TRPM8 (a regulator of epidermal homeostasis) (Bidaux et al, 2015;Patel et al, 2011;Tang et al, 2013). Therefore, this study showed that SD is probably associated with genetic susceptibility (Sanders et al, 2018b).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 67%

“…e. Genome-wide association studies (GWASs) have not detected genome-wide significant associations for seborrheic dermatitis: Sanders et al (2018b) conducted a genome-wide association study that identified two genome-wide significant associations for SD. In this study, they included participants of the Rotterdam Study (Sanders et al, 2018a).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

“…A total of 609 participants, out of 4,050 participants available for analysis, were diagnosed with SD. DNA extraction was performed from whole blood and included 9,008,729 markers (Sanders et al, 2018b). In this study, two genome-wide significant singlenucleotide polymorphisms (SNPs) were identified.…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

“…The first identified SNP is mapped to the MAST4 gene at chromosome 5, which is a part of the intracellular signal transmission cascades and is expressed in hair follicle keratinocytes. The second SNP is mapped between the genes PIRT and SHISA6 on chromosome band 17p12 (Sanders et al, 2018b).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

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