The genetics of self-reported trait impulsivity: Contribution of catecholaminergic gene variants in European ancestry individuals

Bühler, Kora-Mareen; Rincón‐Pérez, Irene; Calleja‐Conde, Javier; Albert, Jacobo; Hinojosa, José Antonio; Giné, Elena; Echeverry‐Alzate, Víctor; López-Moreno, José Antonio; Huertas, Evelio

doi:10.1016/j.paid.2022.111906

Cited by 2 publications

(1 citation statement)

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“…Variants of the COMT gene, involved in the metabolism of catecholamine neurotransmitters, have been implicated in impulsivity. However, it has been suggested that the impact of COMT variants on impulsivity may differ between genders, warranting further investigation into gender-specific effects [ 70 ]. However, it is important to note that gender differences in trait manifestation do not change the underlying role of the core genes involved in particular traits.…”

Section: Core Genes: Ethnic and Gender Perspectivesmentioning

confidence: 99%

Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics

Rančelis

Domarkienė

Ambrozaitytė

et al. 2023

Genes

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A high number of genome variants are associated with complex traits, mainly due to genome-wide association studies (GWAS). Using polygenic risk scores (PRSs) is a widely accepted method for calculating an individual’s complex trait prognosis using such data. Unlike monogenic traits, the practical implementation of complex traits by applying this method still falls behind. Calculating PRSs from all GWAS data has limited practical usability in behaviour traits due to statistical noise and the small effect size from a high number of genome variants involved. From a behaviour traits perspective, complex traits are explored using the concept of core genes from an omnigenic model, aiming to employ a simplified calculation version. Simplification may reduce the accuracy compared to a complete PRS encompassing all trait-associated variants. Integrating genome data with datasets from various disciplines, such as IT and psychology, could lead to better complex trait prediction. This review elucidates the significance of clear biological pathways in understanding behaviour traits. Specifically, it highlights the essential role of genes related to hormones, enzymes, and neurotransmitters as robust core genes in shaping these traits. Significant variations in core genes are prominently observed in behaviour traits such as stress response, impulsivity, and substance use.

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Section: Core Genes: Ethnic and Gender Perspectivesmentioning

confidence: 99%