The Genetics of Sex: Exploring Differences

Arbeitman, Michelle N.; Kopp, Artyom; Siegal, Mark L.; Doren, Mark Van

doi:10.1534/genetics.114.165456

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2016

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sex defined as a binary trait has been proven to be more complex as accumulating research reveals its genetics. Different molecular mechanisms operate in sexual development not only by the gene, but also by other autosomal genes that can control hormone balances [ 2 ]. Sex might be expressed in terms of an ordinal trait.…”

Section: Introductionmentioning

confidence: 99%

Analytical Models For Genetics of Human Traits Influenced By Sex

Lee

2016

View full text Add to dashboard Cite

Analytical models usually assume an additive sex effect by treating it as a covariate to identify genetic associations with sex-influenced traits. Their underlying assumptions are violated by ignoring interactions of sex with genetic factors and heterogeneous genetic effects by sex. Methods to deal with the problems are compared and discussed in this article. Especially, heterogeneity of genetic variance by sex can be assessed employing a mixed model with genetic relationship matrix constructed from genome-wide nucleotide variant information. Estimating genetic architecture of each sex would help understand different prevalence, course, and severity of complex diseases between women and men in the era of personalized medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Analytical Models For Genetics of Human Traits Influenced By Sex

Lee

2016

View full text Add to dashboard Cite

show abstract

The Genetics of Sex: Exploring Differences

Cited by 1 publication

References 15 publications

Analytical Models For Genetics of Human Traits Influenced By Sex

Analytical Models For Genetics of Human Traits Influenced By Sex

Contact Info

Product

Resources

About