The GenoDiabMar registry. A collaborative research platform of “real world” type 2 diabetes patients

Abstract

The GenoDiabMar registry is a prospective study aims to provide data on demographic, biochemical and clinical changes, from a real-world population of Type 2 DM (T2D) patients. This registry is addressed to find new biomarkers related to the micro and macrovascular complications of T2D, especially focused on diabetic nephropathy. The registry includes longitudinal serum and urine samples, DNA bank, as well as data on 227 metabolomics profiles, 77 Immunoglobulin G glycomics traits and others emerging biomarkers. 650 patients aged 69.56 +/- 9.31 with different grades of chronic kidney disease; (G1-2 50.3%, G3 31.4%, G4 10.8% and G5 7.5%) were followed up for 4.96 (+/-0.43) years. Regardless of albuminuria, women lost 0.93 (0.40-1.46) glomerular filtration units per year less than men. 17% of the participant experienced rapid progression of renal function, 75.2% men, with differential risk factors between sexes; severe macroalbuminuria >300mg/g for men OR[IQ] 2.40 [1.29:4.44] and concomitant peripheral vascular disease 3.32 [1.10:9.57] for women. An overall mortality of 23% was detected (38% due to Cardiovascular aetiology). This cohort is postulated as a great tool for scientific collaboration for studies, whether they are focused on T2D, or whether they are interested in comparing differential markers between diabetic and non-diabetic populations

IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes

“…Definitions for macro- and microvascular complications have been described in detail for DiaGene, GenoDiabMar and DCS cohorts 14,15,17 . In short, retinopathy for all studies was scored by an ophthalmologist based on fundus photography, and for the current study defined as present or absent, where present includes all gradations and stages of diabetic retinopathy.…”

“…In short, retinopathy for all studies was scored by an ophthalmologist based on fundus photography, and for the current study defined as present or absent, where present includes all gradations and stages of diabetic retinopathy. Nephropathy was defined as microalbuminuria [albumin/creatinine-ratio (ACR) ≥2.5 mg/mmol for men or ≥3.5 mg/mmol for women] present at two of three consecutive measurements, or when high micro-albuminuria or macro-albuminuria was present at one measurement (ACR ≥12.5 mg/mmol for men or ≥17.5 mg/mmol for women) 14,15,17 . Cardiovascular disease derived from medical records and questionnaires was defined as myocardial infarction, percutaneous coronary intervention/coronary artery bypass graft (PCI/CABG), cerebrovascular accident, transient ischemic attack, and peripheral arterial disease (PAD).…”

“…For this study, we randomly selected a subset of plasma samples from 1600 subjects who donated a sample in 2008/2009. The GenoDiabMar study is a type 2 diabetes adult registry, recruited between 2012 and 2015 from the healthcare area Litoral-Mar of Barcelona, Spain 16,17 . Patients older than 45 years with a medical history of type 2 diabetes for more than 10 years and treated with anti-diabetic drugs were included (n = 640 for the current study).…”