2011
DOI: 10.1016/j.chom.2011.08.005
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The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal Environment

Abstract: Summary Perturbations of the composition of the symbiotic intestinal microbiota can have profound consequences for host metabolism and immunity. In mice, segmented filamentous bacteria (SFB) direct the accumulation of potentially pro-inflammatory Th17 cells in the intestinal lamina propria. We present the genome sequence of SFB isolated from mono-colonized mice, which classifies SFB phylogenetically as a unique member of Clostridiales with a highly reduced genome. Annotation analysis demonstrates that SFB depe… Show more

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Cited by 163 publications
(183 citation statements)
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“…However, the identification of SFB sequences in the genome-wide sequences of 263 human gut metagenomes failed. This supports the conclusion that SFB are not present in human fecal samples (Prakash et al, 2011;Sczesnak et al, 2011). There are few genes in the human gut that are similar to mouse and rat SFB genes (Kuwahara et al, 2011;Prakash et al, 2011;Sczesnak et al, 2011).…”
Section: Introductionsupporting
confidence: 73%
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“…However, the identification of SFB sequences in the genome-wide sequences of 263 human gut metagenomes failed. This supports the conclusion that SFB are not present in human fecal samples (Prakash et al, 2011;Sczesnak et al, 2011). There are few genes in the human gut that are similar to mouse and rat SFB genes (Kuwahara et al, 2011;Prakash et al, 2011;Sczesnak et al, 2011).…”
Section: Introductionsupporting
confidence: 73%
“…This supports the conclusion that SFB are not present in human fecal samples (Prakash et al, 2011;Sczesnak et al, 2011). There are few genes in the human gut that are similar to mouse and rat SFB genes (Kuwahara et al, 2011;Prakash et al, 2011;Sczesnak et al, 2011). The issue of whether SFB inhabit the human gut and their taxonomic relationship with their counterparts in other hosts remains to be elucidated.…”
Section: Introductionsupporting
confidence: 64%
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“…Because of their extracellular location and limited catalytic domains, these proteins might be components of surface structures that are involved in niche adaptation (Pamp et al, 2012). The polymorphisms found in the surface proteins suggest the differentiation of SFB among their host animal strains, which may indicate the species (or strain)-specific adaptation of SFB to each host (Kuwahara et al, 2011;Prakash et al, 2011;Sczesnak et al, 2011). Although sequence similarity was quite high between genomes from the same host species (98%-99%), the authors could detect distinct differences between different mice strains, thus supporting the hypothesis of host speciation.…”
Section: Segmented Filamentous Bacteria From Mouse Intestinementioning
confidence: 99%