The Genome of the Common Marmoset

Vallender, Eric J.

doi:10.1016/b978-0-12-811829-0.00019-4

Cited by 2 publications

(2 citation statements)

References 139 publications

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“…Among New World monkeys there is growing interest in common marmosets ( Callithrix jacchus ), small simians (adults ~ 300 g) which have a published whole draft genome [ 27 ] and newer annotated reference assemblies. Marmosets are notable for litters of 2–4 offspring that are hematopoietic chimeras, as outgroups for catarrhine evolutionary studies, and for their potential in genetic engineering studies [ 28 , 29 ]. Regarding prosimians an ongoing initiative is investigating the translational potential of mouse lemurs ( Microcebus spp.…”

Section: Nonhuman Primate Models Of Diseasementioning

confidence: 99%

Nonhuman primate genetic models for the study of rare diseases

Vallender

Hotchkiss

Lewis

et al. 2023

Orphanet J Rare Dis

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Pre-clinical research and development relies heavily upon translationally valid models of disease. A major difficulty in understanding the biology of, and developing treatments for, rare disease is the lack of animal models. It is important that these models not only recapitulate the presentation of the disease in humans, but also that they share functionally equivalent underlying genetic causes. Nonhuman primates share physiological, anatomical, and behavioral similarities with humans resulting from close evolutionary relationships and high genetic homology. As the post-genomic era develops and next generation sequencing allows for the resequencing and screening of large populations of research animals, naturally occurring genetic variation in nonhuman primates with clinically relevant phenotypes is regularly emerging. Here we review nonhuman primate models of multiple rare genetic diseases with a focus on the similarities and differences in manifestation and etiologies across species. We discuss how these models are being developed and how they can offer new tools and opportunities for researchers interested in exploring novel therapeutics for these and other genetic diseases. Modeling human genetic diseases in translationally relevant nonhuman primates presents new prospects for development of therapeutics and a better understanding of rare diseases. The post-genomic era offers the opportunity for the discovery and further development of more models like those discussed here.

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Section: Nonhuman Primate Models Of Diseasementioning

confidence: 99%

Nonhuman primate genetic models for the study of rare diseases

Vallender

Hotchkiss

Lewis

et al. 2023

Orphanet J Rare Dis

Self Cite

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“…Another characteristic feature of the CMs is minimal diversity at both major histocompatibility (MHC) Classes I and II loci [ 17 , 18 , 19 ]. One consequence of this reduced variation is that callitrichids are much more tolerant to transplantation [ 20 , 21 ], with xenografts between species within the family surviving an average of three weeks, and allografts within species often lasting months [ 22 , 23 ], potentially making it possible to perform allotransplantation between CMs in the absence of immunosuppressive agents [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Common Marmoset Cell Lines and Their Applications in Biomedical Research

Bayurova,

Zhitkevich,

Avdoshina

et al. 2023

Cells

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Common marmosets (Callithrix jacchus; CMs) are small New World primates widely used in biomedical research. Early stages of such research often include in vitro experiments which require standardized and well-characterized CM cell cultures derived from different tissues. Despite the long history of laboratory work with CMs and high translational potential of such studies, the number of available standardized, well-defined, stable, and validated CM cell lines is still small. While primary cells and immortalized cell lines are mostly used for the studies of infectious diseases, biochemical research, and targeted gene therapy, the main current applications of CM embryonic stem cells and induced pluripotent stem cells are regenerative medicine, stem cell research, generation of transgenic CMs, transplantology, cell therapy, reproductive physiology, oncology, and neurodegenerative diseases. In this review we summarize the data on the main advantages, drawbacks and research applications of CM cell lines published to date including primary cells, immortalized cell lines, lymphoblastoid cell lines, embryonic stem cells, and induced pluripotent stem cells.

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The Genome of the Common Marmoset

Cited by 2 publications

References 139 publications

Nonhuman primate genetic models for the study of rare diseases

Nonhuman primate genetic models for the study of rare diseases

Common Marmoset Cell Lines and Their Applications in Biomedical Research

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