2018
DOI: 10.1101/369959
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The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle

Abstract: Jellyfish (medusae) are a distinctive life-cycle stage of medusozoan cnidarians. They are major marine predators, with integrated neurosensory, muscular and organ systems. The genetic foundations of this complex form are largely unknown. We report the draft genome of the hydrozoan jellyfish Clytia hemisphaerica and use multiple transcriptomes to determine gene use across life-cycle stages. Medusa, planula larva and polyp are each characterised by distinct transcriptome signatures reflecting abrupt life cycle t… Show more

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Cited by 10 publications
(6 citation statements)
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“…We used a database of metazoan proteins, updated from ref 73 , as the basis for an OMA analysis to calculate orthologous groups, performing two separate runs, one including Xenoturbella and acoels, and one with only Xenoturbella . We converted OMA gene OrthologousMatrix.txt files into binary gene presence absence matrices in Nexus format with datatype = restriction.…”
Section: Methodsmentioning
confidence: 99%
“…We used a database of metazoan proteins, updated from ref 73 , as the basis for an OMA analysis to calculate orthologous groups, performing two separate runs, one including Xenoturbella and acoels, and one with only Xenoturbella . We converted OMA gene OrthologousMatrix.txt files into binary gene presence absence matrices in Nexus format with datatype = restriction.…”
Section: Methodsmentioning
confidence: 99%
“…Other non‐bilaterians, including sponges and ctenophores, are catching up rapidly . Large genomic/transcriptomic datasets, including also single cell data, can now be harnessed for functional research. Non‐bilaterians offer a fresh complementation to work done on traditional animal models, given their phylogenetic position and specific features such as regenerative ability, and resistance to cancer and aging.…”
Section: Discussionmentioning
confidence: 99%
“…We identified a single conserved Clytia Spo11 gene using genome and transcriptome data (Supplementary Figure S2) (22). We also identified other key meiosis synaptonemal complex components such as Sycp1 and Sycp3, and the repair pathway proteins Rad51, Mlh1, Dmc1 (Supplementary Figure S3, Supplementary data S3-S9).…”
Section: Synapsis In Clytia Is Spo11 Dependentmentioning
confidence: 99%
“…Clytia hemisphaerica genes, for antibody, guide RNA, and FISH probe design, were identified via BLAST against the Clytia genome http://marimba.obs-vlfr.fr/ (22). Gene alignments were made using MAFFT v7.453 L-INS-i (30), and gene phylogenies generated with IQ-TREE(31) using a LG+F+R4 model.…”
Section: Gene Identification and Homologymentioning
confidence: 99%