The GENOMES UNCOUPLED1 protein has an ancient, highly conserved role in chloroplast gene expression but not in retrograde signalling

Honkanen, Suvi; Small, Ian

doi:10.1101/2022.02.25.481377

Cited by 2 publications

(1 citation statement)

References 81 publications

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“…Further, GUN1 was found to interact with many proteins of different processes. However, GUN1 exhibits a PPR domain, a motif typically found only in RNA interacting proteins and a very recent study focussing on this structural aspect raises severe doubts about a direct involvement of GUN1 in retrograde biogenic signalling (Honaken and Small 2022). Thus, further investigations will be required to verify the multiple protein interactions and to finally clarify the role of GUN1 (and its potential interaction partners) in chloroplast biogenesis.…”

Section: The Physical Nature Of Retrograde Biogenic Signalsmentioning

confidence: 99%

Biogenic signals from plastids and their role in chloroplast development

Liebers

Cozzi

Uecker

et al. 2022

Journal of Experimental Botany

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Plant seeds do not contain differentiated chloroplasts. Upon germination the seedling, thus, need to gain photoautotrophy before storage energies are depleted. This requires the coordinated expression of photosynthesis genes encoded in nuclear and plastid genomes. Chloroplast biogenesis needs to be additionally coordinated with the light regulation network that controls seedling development. This coordination is achieved by nucleus-to-plastid signals called anterograde and plastid-to-nucleus signals coined retrograde. Retrograde signals sent from plastids during intial chloroplast biogenesis are also called biogenic signals. They have been recognized as highly important for proper chloroplast biogenesis and for seedling development. The molecular nature, transport, targets and signalling function of biogenic signals are, however, under debate. Several studies disproved the involvement of a number of key components that were at the base of initial models of retrograde signalling. New models now propose major roles for a functional feedback between plastid and cytosolic protein homeostasis in signaling plastid dysfunction as well as the action of dually localized nucleo-plastidic proteins that coordinate chloroplast biogenesis with light-dependent control of seedling development. This review provides a survey of the developments in this research field, summarizes the unsolved questions, high-lights several recent advances and discusses potential new working modes.

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Section: The Physical Nature Of Retrograde Biogenic Signalsmentioning

confidence: 99%

Biogenic signals from plastids and their role in chloroplast development

Liebers

Cozzi

Uecker

et al. 2022

Journal of Experimental Botany

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An Overview of Pentatricopeptide Repeat (PPR) Proteins in the Moss Physcomitrium patens and Their Role in Organellar Gene Expression

Sugita

2022

Plants

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Pentatricopeptide repeat (PPR) proteins are one type of helical repeat protein that are widespread in eukaryotes. In particular, there are several hundred PPR members in flowering plants. The majority of PPR proteins are localized in the plastids and mitochondria, where they play a crucial role in various aspects of RNA metabolism at the post-transcriptional and translational steps during gene expression. Among the early land plants, the moss Physcomitrium (formerly Physcomitrella) patens has at least 107 PPR protein-encoding genes, but most of their functions remain unclear. To elucidate the functions of PPR proteins, a reverse-genetics approach has been applied to P. patens. To date, the molecular functions of 22 PPR proteins were identified as essential factors required for either mRNA processing and stabilization, RNA splicing, or RNA editing. This review examines the P. patens PPR gene family and their current functional characterization. Similarities and a diversity of functions of PPR proteins between P. patens and flowering plants and their roles in the post-transcriptional regulation of organellar gene expression are discussed.

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The GENOMES UNCOUPLED1 protein has an ancient, highly conserved role in chloroplast gene expression but not in retrograde signalling

Cited by 2 publications

References 81 publications

Biogenic signals from plastids and their role in chloroplast development

Biogenic signals from plastids and their role in chloroplast development

An Overview of Pentatricopeptide Repeat (PPR) Proteins in the Moss Physcomitrium patens and Their Role in Organellar Gene Expression

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