The genus Bridelia: A phytochemical and ethnopharmacological review

Ngueyem, T.A.; Brusotti, Gloria; Caccialanza, Gabriele; Finzi, Paola Vita

doi:10.1016/j.jep.2009.05.019

Cited by 86 publications

(67 citation statements)

References 56 publications

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“…Historically, flavonoids are used to treat and prevent various infectious and toxin-mediated diseases, including sores, wound infections (Cushnie and Lamb, 2005), acne, respiratory infections (Gutierrez et al, 2008), gastrointestinal disease (Shan et al, 2007) and urinary tract infections (Ngueyem et al, 2009), among others. For this reason, flavonoids have been extensively studied for their antibacterial properties (Cushnie et al, 2003;Cushnie and Lamb, 2005;Mehndiratta et al, 2010;Cushnie and Lamb, 2011).…”

Section: Introductionmentioning

confidence: 99%

Additive antibacterial activity of naringenin and antibiotic combinations against multidrug resistant Staphylococcus aureus

uni¹,

Mothlalamme²,

Daniels³

et al. 2015

Afr. J. Microbiol. Res.

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Methicillin-resistant Staphylococcus aureus has been causing numerous problems in the health care sector. This is mainly due to its ability to develop resistance to a number of antibiotics used to treat staphylococcal infections. Medicinal plants have been used to treat various ailments over the years and are generating a lot of interest as alternative treatment options. Naringenin is a plant derived flavonoid that possesses antibacterial properties, among others. This study assessed the effect of combinations of naringenin and four antibiotics against two Staphylococcus aureus strains. The minimum inhibitory concentrations were determined using the disk diffusion and broth microdilution assays. In the disk diffusion assay, naringenin did not inhibit bacterial growth, nor did it enhance the antibacterial activity of the antibiotics in the combination study. This was attributed to its slow rate of diffusion out of the disks. On the contrary, in the broth microdilution assay, naringenin exhibited additive effects when combined with the antibiotics (at sub-inhibitory concentrations). These results show the potential of naringenin as an antibacterial agent. Furthermore, the additive effects observed at low naringenin concentrations showed that it can potentially be used in combination with antibiotics against multidrug resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Additive antibacterial activity of naringenin and antibiotic combinations against multidrug resistant Staphylococcus aureus

uni¹,

Mothlalamme²,

Daniels³

et al. 2015

Afr. J. Microbiol. Res.

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show abstract

“…In Africa and Asia around 60 species of Bridelia, (Phyllanthaceae) are found and several species are used as folkloric medicines due to their antiamebic, antianemic, antibacterial, anticonvulsant, anti-diabetic, antidiarrhoeal, antihelmintic, antiinflammatory, antimalarial, antinociceptive, antiviral and hypoglycemic properties [9]. The three Bridelia species of the Phyllanthaceae family available in Bangladesh, Bridelia verrucosa (Haines), Bridelia stipularis (L) and Bridelia tomentosa (Blume) are shrubs or small evergreen trees [10].…”

Section: Introductionmentioning

confidence: 99%

<i>In Vitro</i> Antioxidant and Thrombolytic Activities of <i>Bridelia</i> Species Growing in Bangladesh

Anjum¹,

Sikder

Haque

et al. 2013

J. Sci. Res.

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The organic soluble extractives of three Bridelia species, B. verrucosa, B. stipularis and B. tomentosa growing in Bangladesh were subjected to screening for free radical scavenging activity, total antioxidant capacity and total phenolic content. All of the methanol extracts of the these plants and their kupchan fractions showed moderate to strong free radical scavenging activity, the total antioxidant capacity and total phenolic content, of which the methanol extract of the leaf of B. verrucosa revealed highest activity having IC 50 value of 6.35 µg/ml. All the extractives of three plants were also studied for their thrombolytic potential. Among the three plants the carbon tetrachloride soluble fraction and methanol extract of leaf and aqueous soluble fraction of bark of B. tomentosa, methanol extract of bark of B. stipularis and carbon tetrachloride soluble fraction of leaf of B. verrucosa exhibited highest thrombolytic activity with clot lysis value of 41.46%, 34.85%, 37.04%, 36.45% and 33.72%, respectively. Standard streptokinase was used as positive control which exhibited 61.50% lysis of clot while the negative control water revealed 2.56% lysis of clot.

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“…Tannins were isolated from the bark of B.scandens [23], fatty alcohol called bridely alcohol and phlobatannin was isolated from leaves [24], taraxenone and taraxenone was from roots [25] till date.…”

Section: Chemical Constituentsmentioning

confidence: 99%