The Genus Burkholderia

Woods, Donald E.; Sokol, Pamela A.

doi:10.1007/0-387-30745-1_40

Cited by 15 publications

(10 citation statements)

References 107 publications

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“…2), which contained some pathogenic members (e.g., Burkholderia mallei responsible for glanders disease that occurs in horses and related animals, Burkholderia pseudomallei a causative agent of melioidosis, Burkholderia cepacia an important pathogen for pulmonary infections in humans with cystic fibrosis) (Woods and Sokol 2006;Djordjevic et al 2013). These findings are consistent with site A1 being the furthest upstream site that is closest to areas with animal husbandry and sites B3 and C1 being in the urban environment and subject to receiving waters from hospital waste and non-treated sewage.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

144

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Antibiotic resistance genes (ARGs) in urban rivers are a serious public health concern in regions with poorly planned, rapid development. To gain insights into the predominant factors affecting the fate of ARGs in a highly polluted urban river in eastern China, a total of 285 ARGs, microbial communities, and 20 physicochemical parameters were analyzed for 17 sites. A total of 258 unique ARGs were detected using high-throughput qPCR, and the absolute abundance of total ARGs was positively correlated with total organic carbon and total dissolved nitrogen concentrations (P < 0.01). ARG abundance and diversity were greatly altered by microbial community structure. Variation partitioning analysis showed that the combined effects of multiple factors contributed to the profile and dissemination of ARGs, and variation of microbial communities was the major factor affecting the distribution of ARGs. The disparate distribution of some bacteria, including Bacteroides from mammalian gastrointestinal flora, Burkholderia from zoonotic infectious diseases, and Zoogloea from wastewater treatment, indicates that the urban river was strongly influenced by point-source pollution. Results imply that microbial community shifts caused by changes in water quality may lead to the spread of ARGs, and point-source pollution in urban rivers requires greater attention to control the transfer of ARGs between environmental bacteria and pathogens.

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Section: Discussionmentioning

confidence: 99%

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

144

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“…Burkholderia is found in different environments such as water, soil, and the plant rhizosphere (Woods & Sokol, ). It was first described as a plant pathogen (Yabuuchi et al ., ), but it can also be hazardous to humans and animals (Coenye & Vandamme, ).…”

Section: Discussionmentioning

confidence: 99%

Evidence for a conserved microbiota across the different developmental stages of Plodia interpunctella

et al. 2017

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Diversity and composition of lepidopteran microbiotas are poorly investigated, especially across the different developmental stages. To improve this knowledge, we characterize the microbiota among different developmental stages of the Indian meal moth, Plodia interpunctella, which is considered one of the major pest of commodities worldwide. Using culture-independent approach based on Illumina 16S rRNA gene sequencing we characterized the microbiota of four developmental stages: eggs, first-, and last-instar larvae, and adult. A total of 1022 bacterial OTUs were obtained, showing a quite diversified microbiota associated to all the analyzed stages. The microbiotas associated with P. interpunctella resulted almost constant throughout the developmental stages, with approximately 77% of bacterial OTUs belonging to the phylum of Proteobacteria. The dominant bacterial genus is represented by Burkholderia (∼64%), followed by Propionibacterium, Delftia, Pseudomonas, and Stenotrophomonas. A core bacterial community, composed of 139 OTUs, was detected in all the developmental stages, among which 112 OTUs were assigned to the genus Burkholderia. A phylogenetic reconstruction, based on the 16S rRNA, revealed that our Burkholderia OTUs clustered with Burkholderia cepacia complex, in the same group of those isolated from the hemipterans Gossyparia spuria and Acanthococcus aceris. The functional profiling, predicted on the base of the bacterial 16S rRNA, indicates differences in the metabolic pathways related to metabolism of amino acids between preimaginal and adult stages. We can hypothesize that bacteria may support the insect host during preimaginal stages.

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“…There are two main factors that can be attributed to the ecological versatility of the members of this genus which includes: (1) the huge coding capacity of their large multireplicon genomes (6–9 Mb) that allow the members of the genus to be metabolically robust; and (2) an array of insertion sequences in their genomes which promote genomic plasticity and general adaptability (Lessie et al, 1996). Their survival and persistence, in the environment and in host cells, offers a notable example of bacterial adaptation (Woods and Sokol, 2006). …”

Section: Burkholderia Sppmentioning

confidence: 99%

Burkholderia vaccines: are we moving forward?

Choh¹,

Ong²,

Vellasamy³

et al. 2013

Front. Cell. Inf. Microbio.

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The genus Burkholderia consists of diverse species which includes both “friends” and “foes.” Some of the “friendly” Burkholderia spp. are extensively used in the biotechnological and agricultural industry for bioremediation and biocontrol. However, several members of the genus including B. pseudomallei, B. mallei, and B. cepacia, are known to cause fatal disease in both humans and animals. B. pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively, while B. cepacia infection is lethal to cystic fibrosis (CF) patients. Due to the high rate of infectivity and intrinsic resistance to many commonly used antibiotics, together with high mortality rate, B. mallei and B. pseudomallei are considered to be potential biological warfare agents. Treatments of the infections caused by these bacteria are often unsuccessful with frequent relapse of the infection. Thus, we are at a crucial stage of the need for Burkholderia vaccines. Although the search for a prophylactic therapy candidate continues, to date development of vaccines has not advanced beyond research to human clinical trials. In this article, we review the current research on development of safe vaccines with high efficacy against B. pseudomallei, B. mallei, and B. cepacia. It can be concluded that further research will enable elucidation of the potential benefits and risks of Burkholderia vaccines.

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The Genus Burkholderia

Cited by 15 publications

References 107 publications

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Evidence for a conserved microbiota across the different developmental stages of Plodia interpunctella

Burkholderia vaccines: are we moving forward?

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