Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
This study aims to examine the biogenic production, characterization, and anti‐acetylcholinesterase (AAChE) properties of polyherbal formulation PHF‐extract‐synthesized silver nanoparticles (PHF‐AgNPs). The Elapidae snake Bungarus sindanus has extremely dangerous venom for humans and contains a high amount of AChE (acetylcholinesterase). Inhibiting AChE leads to acetylcholine buildup, affecting neurotransmission. The study tested silver nanoparticles as AChE inhibitors using kinetics. Their production was confirmed through ultraviolet (UV) spectrometry at 425 nm (SPR peak of 1.94), and stabilizing functional groups were identified via Fourier transform infrared spectroscopy (FT‐IR). The average length of 20 nm was confirmed by analyzing the scanning electron microscopy (SEM) data. Energy‐dispersive X‐ray spectroscopy (EDX) identified silver as the primary component of PHF‐AgNPs (26%). Statistical analysis showed that the activity of AChE in krait venom decreased by up to 45% and 37% at a given dose of ACh (0.5 mM) by PHF and AgNPs, respectively. Utilizing the Lineweaver‐Burk plot for kinetic analysis, a competitive type of inhibition is found.Research Highlights Successfully synthesized PHF‐extract‐induced silver nanoparticles (PHF‐AgNPs) demonstrated through UV spectrometry and characterized as crystalline with an average size of 45 nm by X‐ray diffraction. PHF‐AgNPs effectively inhibited acetylcholinesterase (AChE), an enzyme critical in neurotransmission, reducing its activity in krait venom by up to 45% at certain concentrations. Kinetic analysis revealed that the inhibition mechanism of AChE by PHF‐AgNPs is competitive, offering potential for therapeutic applications in neurologically related conditions.
This study aims to examine the biogenic production, characterization, and anti‐acetylcholinesterase (AAChE) properties of polyherbal formulation PHF‐extract‐synthesized silver nanoparticles (PHF‐AgNPs). The Elapidae snake Bungarus sindanus has extremely dangerous venom for humans and contains a high amount of AChE (acetylcholinesterase). Inhibiting AChE leads to acetylcholine buildup, affecting neurotransmission. The study tested silver nanoparticles as AChE inhibitors using kinetics. Their production was confirmed through ultraviolet (UV) spectrometry at 425 nm (SPR peak of 1.94), and stabilizing functional groups were identified via Fourier transform infrared spectroscopy (FT‐IR). The average length of 20 nm was confirmed by analyzing the scanning electron microscopy (SEM) data. Energy‐dispersive X‐ray spectroscopy (EDX) identified silver as the primary component of PHF‐AgNPs (26%). Statistical analysis showed that the activity of AChE in krait venom decreased by up to 45% and 37% at a given dose of ACh (0.5 mM) by PHF and AgNPs, respectively. Utilizing the Lineweaver‐Burk plot for kinetic analysis, a competitive type of inhibition is found.Research Highlights Successfully synthesized PHF‐extract‐induced silver nanoparticles (PHF‐AgNPs) demonstrated through UV spectrometry and characterized as crystalline with an average size of 45 nm by X‐ray diffraction. PHF‐AgNPs effectively inhibited acetylcholinesterase (AChE), an enzyme critical in neurotransmission, reducing its activity in krait venom by up to 45% at certain concentrations. Kinetic analysis revealed that the inhibition mechanism of AChE by PHF‐AgNPs is competitive, offering potential for therapeutic applications in neurologically related conditions.
Objective: This study evaluates the antitermitic activity of Rosmarinus officinalis and Chenopodium ambrosioides essential oils against Nasutitermes corniger termites. Theoretical Framework: Termite control is done using pesticides, but many are toxic to the environment and human health. Among termite species, Nasutitermes corniger is considered a pest in urban areas, due to its high destructive power in construction wood and plants. Method: Essential oils were obtained by hydrodistillation and analyzed by GC-MS. Antitermitic activity was evaluated by bioassay without food choice, at concentrations of 12.5; 25.0; 50.0 and 100 mg/mL, with five repetitions. Results and Discussion: In the composition of R. officinalis essential oils, 51 compounds were identified representing 99.43% and 99.52% (dry and fresh leaves, respectively), with camphor being the majority. For C. ambrosioides, 29 compounds were identified, representing 93.76% and 95.06% of the compositions (dried and fresh leaves, respectively), and the main constituent of both oils was α-terpinene (63.29% and 57.50%). In the antithermic test, the concentration of 100 mg/mL of R. officinalis showed 100% mortality, while the essential oil of C. ambrosioides showed strong antithermic activity with high mortality from the concentration of 25 mg/mL. Research Implications: The research presents the antitermitic potential of the essential oils of Rosmarinus officinalis and Chenopodium ambrosioides against Nasutitermes corniger termites. Originality/Value: The search for new antitermitic products with high biodegradability and low toxicity has become necessary, with essential oils being promising due to their variety of biological properties.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.