The genus Clematis (Ranunculaceae): Chemical and pharmacological perspectives

Chawla, Rakesh; Kumar, Suresh; Sharma, Anupam

doi:10.1016/j.jep.2012.06.014

Cited by 91 publications

(43 citation statements)

References 96 publications

(81 reference statements)

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“…Solanum nigrum is also toxic, but the more toxic fruits are not used, and only one or two leaves are used in mixtures. Clematis flammula leaves are also toxic but they are only used in baths; whether seeds are toxic is not known (Chawla et al, 2012); in Imegdale seeds are chewed but not ingested. Subacute toxic effects where observed in rats when a Retama species was administered repeatedly, indicating possible toxicity of the species reported here (Algandaby, 2015).…”

Section: Previously Unreported Medicinal Plants In Moroccomentioning

confidence: 99%

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

Teixidor‐Toneu

Martin²,

Ouhammou

et al. 2016

Journal of Ethnopharmacology

125

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ethnomedicinal survey of a Tashelhitspeaking community in the High Atlas, Morocco, Journal of Ethnopharmacology, http://dx.doi.org/10. 1016/j.jep.2016.05.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACT Ethnopharmacological relevanceTraditional knowledge about medicinal plants from a poorly studied region, the High Atlas in Morocco, is reported here for the first time; this permits consideration of efficacy and safety of current practices whilst highlighting species previously not known to have traditional medicinal use. Aim of the studyOur study aims to document local medicinal plant knowledge among Tashelhit speaking communities through ethnobotanical survey, identifying preferred species and new medicinal plant citations and illuminating the relationship between emic and etic ailment classifications. Materials and methodsEthnobotanical data were collected using standard methods and with prior informed consent obtained before all interactions, data were characterized using descriptive indices and medicinal plants and healing strategies relevant to local livelihoods were identified.Results 151 vernacular names corresponding to 159 botanical species were found to be used to treat 36 folk ailments grouped in 14 biomedical use categories. Thirty-five (22%) are new medicinal plant records in Morocco, and 26 described as used for the first time anywhere. Fidelity levels (FL) revealed low specificity in plant use, particularly for the most commonly reported plants. Most plants are used in mixtures. Plant use is driven by local concepts of disease, including "hot" and "cold" classification and beliefs in supernatural forces. 2 ConclusionLocal medicinal plant knowledge is rich in the High Atlas, where local populations still rely on medicinal plants for healthcare. We found experimental evidence of safe and effective use of medicinal plants in the High Atlas; but we highlight the use of eight poisonous species.

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Section: Previously Unreported Medicinal Plants In Moroccomentioning

confidence: 99%

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

Teixidor‐Toneu

Martin²,

Ouhammou

et al. 2016

Journal of Ethnopharmacology

125

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“…All the species of this genus contain protoanemonine, a substance which irritates the skin and the walls of the digestive tract [69]. The young shoots of C. vitalba are sometimes eaten (after boiling) in central and southern Italy [70,71].…”

Section: Local Names In 1903 -mentioning

confidence: 99%

A century of changes in wild food plant use in coastal Croatia: the example of Krk and Poljica

et al. 2016

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The aim of this study was to document the use of wild foods in two locations in the coastal part of Croatia -on the island of Krk and in the Poljica area, near Split. We chose these places as they have historical data on plant use (1900 and 1903 respectively). We carried out 67 interviews in Poljica and 55 interviews in Krk to estimate the current use and knowledge of wild foods. Altogether, 80 species of wild food and herbal tea species of plants were recorded in Poljica and 76 in Krk. On average, 13.2 species were listed by per interview in Poljica, including 7.1 species of wild vegetables, and in Krk 14.6 species, including 7.9 species of wild vegetables. Out of the list of plant names recorded in the past, in Krk, we identified 82% of the taxa and in Poljica 86%.

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“…Thus, the structure of 3 was identified as The NMR data of 7 were very similar to those of 6, except for the presence of signals corresponding to an additional rhamnose unit. In the HMBC spectrum of 7, the correlation between H-1 (δ H 5.45) of the additional rhamnose moiety and C-6 (δ C 68.8) of D-glucose 2 was observed, which indicated that the additional rhamnose unit (L-rhamnose 3 ) was attached to the C-6 position of D-glucose 2 . Therefore, the structure of 7 was determined as…”

Section: Resultsmentioning

confidence: 97%

“…The 50% EtOH and 70% EtOH eluates were further purified by repeated column chromatography over middle chromatogram isolated (MCI) gel, octadecyl silica (ODS), silica gel and preparative HPLC to afford eight new bisdesmosidic triterpenoid saponins (1)(2)(3)(4)(5)(6)(7)(8), named as clematiunicinosides A-H, as well as eleven known ones (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Resultsmentioning

confidence: 99%

Triterpenoid Saponins from the Roots of <i>Clematis uncinata</i>

Huang

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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Eight new bisdesmosidic triterpenoid saponins, clematiunicinosides A-H (1-8), along with eleven known ones (9-19), were isolated from the roots of Clematis uncinata. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. All the isolated saponins were tested for their cytotoxic activities on human caski cervical cancer (Caski) cells, and compounds 13, 17 and 19 exhibited inhibitory effect on Caski cells. Key words triterpenoid saponin; Clematis uncinata; RanunculaceaeThe genus Clematis, belonging to the family Ranunculaceae, comprises of more than 300 species distributed throughout the world.1) Three plants of this genus (Clematis chinensis OSBECK, C. hexapetala PALL., and C. mandshurica RUPR.) are officially used as "Weilingxian," a traditional Chinese herbal drug, for the treatment of inflammation and cancer in China. 2)Previous phytochemical investigations had demonstrated that triterpenoid saponins are the dominant constituents of this genus.3) Some of them showed significant anti-inflammatory and antitumor activities. [4][5][6][7] During the course of our ongoing program to search for new saponins from traditional Chinese medicine, [8][9][10][11][12] Clematis uncinata was selected as a subject for this study. The plant Clematis uncinata is mainly distributed in southern China, such as Guizhou, Zhejiang, Fujian, Guangdong and Guangxi provinces.13) The blank in chemical constituent, the potential medicinal importance and our interest in the chemistry of saponins prompted us to carry out a phytochemical investigation on this plant, which led to the isolation of eight new bisdesmosidic triterpenoid saponins, clematiunicinosides A-H (1-8), together with eleven known ones (9-19). In addition, the cytotoxic effects of the isolated triterpenoid saponins on Caski cells were evaluated. The present paper reports the isolation, structural elucidation and antiproliferative activities of these compounds. Results and DiscussionThe 70% (V/V) EtOH extract of the roots of C. uncinata was subjected to D101 macroporous resin column eluted successively with H 2 O, 10% EtOH, 30% EtOH, 50% EtOH and 70% EtOH. The 50% EtOH and 70% EtOH eluates were further purified by repeated column chromatography over middle chromatogram isolated (MCI) gel, octadecyl silica (ODS), silica gel and preparative HPLC to afford eight new bisdesmosidic triterpenoid saponins (1-8), named as clematiunicinosides A-H, as well as eleven known ones (9-19).Clematiunicinoside A (1) was obtained as an amorphous powder. It showed positive reactions to the LiebermannBurchard and Molish tests, which suggested that 1 might be a triterpenoid glycoside. The molecular formula of 1 was established as C 70 2, 104.8, 106.8, 102.7, 104.6, 95.6 and 101.3, respectively (Tables 1, 2). Acid hydrolysis of 1 afforded Dglucose, D-ribose, L-arabinose and L-rhamnose, which were identified by HPLC analysis.15) The relative anomeric configurations of the sugar moieties were determined to be β for the D-glucose (J=8.0 Hz) and α for the L-...

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The genus Clematis (Ranunculaceae): Chemical and pharmacological perspectives

Cited by 91 publications

References 96 publications

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

A century of changes in wild food plant use in coastal Croatia: the example of Krk and Poljica

Triterpenoid Saponins from the Roots of <i>Clematis uncinata</i>

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