The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology

Olatunji, Opeyemi Joshua; Tang, Jian; Tola, Adesola Julius; Auberon, Florence; Oluwaniyi, Omolara O.; Ouyang, Zhen

doi:10.1016/j.fitote.2018.05.010

Cited by 128 publications

(106 citation statements)

References 168 publications

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“…[9 -11] C. cicadae has been shown to accumulate several bioactive constituents including polysaccharides, nucleosides, cyclopeptides and steroids. [9] Specifically, the extracts from the mycelia of C. cicadae is extremely rich in nucleosides particularly adenosine, cordycepin and N 6 -2-(hydroxyethyl)adenosine (Figure 1) with well reported antioxidant and anti-inflammatory properties as well as enhancement of testicular function. [12 -15] Despite the sizeable number of reports on C. cicadae's modulatory effect on several toxicity models, its effect on CISP-induced testicular damage remains as an open question.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Pei

et al. 2020

Chemistry & Biodiversity

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Cisplatin (CISP) is an efficacious anticancer agent used in chemotherapy, however, the constraint to its clinical utility is the stray organ toxicity including testicular damage linked to oxidative and inflammatory cascades. This study aimed to explore the protective effect of nucleosides-rich extract from Cordyceps cicadae (NRCE) against CISP-induced testicular damage in rats. Rats were subjected to prophylactic oral administration of NRCE (50, 100 and 400 mg/kg body weight/day) for 7 days prior to testicular toxicity induced by CISP (10 mg/kg, ip) and were sacrificed after 72 h post-CISP injection. Cisplatin caused significant deficits in sperm count, viability and motility, testosterone and follicle stimulating hormone (FSH) compared to normal control. It depressed testicular activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), total antioxidant content (TAC), whereas malondialdehyde (MDA) increased remarkably. CISP considerably increased tumor necrosis factor-alpha (TNF-α) and interleukin-one beta (IL-1β) with alterations in testis histology compared to normal control. Interestingly, NRCE pretreatment inhibited the CISP-induced alterations in reproductive indices, restored the antioxidant activities in testes as well as inflammatory mediators and histology comparable to control. Our findings demonstrate that NRCE could prevent CISP testicular damage via inhibition of oxidative stress and proinflammation in rats.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Pei

et al. 2020

Chemistry & Biodiversity

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“…Sacc is a fungal parasite that grows on the larva of Lepidoptera. It is considered to be a health-promoting product and, also, one of the best-known herbal remedies for the treatment of airway diseases, such as asthma and lung inflammation [ 9 ]. Cordyceps sinensis with its parasitic hosts has a harsh growing environment in the wild, and the selling price (up to US 30 per gram, cf.…”

Section: Introductionmentioning

confidence: 99%

“…Cordyceps sinensis with its parasitic hosts has a harsh growing environment in the wild, and the selling price (up to US 30 per gram, cf. Amazon website) is soaring due to the recent elucidation of the pharmacological basis of its health-promoting effects [ 9 ]. Currently, Cordyceps mycelium is cultivated by a process involving deep fermentation and has been widely used as a substitute for Cordyceps sinensis in medicines or herbal products [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

et al. 2020

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Allergic rhinitis and asthma are common chronic allergic diseases of the respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated inflammation and the involvement of type 2 T helper cells, mast cells, and eosinophils. Cordyceps sinensis (Berk.) Sacc is a fungal parasite on the larva of Lepidoptera. It has been considered to be a health-promoting food and, also, one of the best-known herbal remedies for the treatment of airway diseases, such as asthma and lung inflammation. In the present study, we demonstrated the antiallergic rhinitis effect of Cs-4, a water extract prepared from the mycelium culture of Cordyceps sinensis (Berk) Sacc, on ovalbumin (OVA)-induced allergic rhinitis in mice and the anti-asthmatic effect of Cs-4 in a rat model of asthma. Treatment with Cs-4 suppressed the nasal symptoms induced in OVA-sensitized and challenged mice. The inhibition was associated with a reduction in IgE/OVA-IgE and interleukin (IL)-4/IL-13 levels in the nasal fluid. Cs-4 treatment also decreased airway responsiveness and ameliorated the scratching behavior in capsaicin-challenged rats. It also reduced plasma IgE levels, as well as IgE and eosinophil peroxidase levels, in the bronchoalveolar fluid. Cs-4 treatment completely suppressed the increases in IL-4, IL-5, and IL-13 levels in rat lung tissue. In conclusion, our results suggest that Cs-4 has the potential to alleviate immune hypersensitivity reactions in allergic rhinitis and asthma.

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“…In Chinese traditional medicine, C. cicadae has a long history of use as treatment for fever, convulsion, heart palpitation, and diabetes (Kuo et al, ; Olatunji, Tang et al, ; Zhang, Olatunji, Chen, Tola, & Oluwaniyi, ). C. cicadae is an interesting source of a number of bioactive compounds namely sterols (ergosterol and ergosterol peroxide), nucleosides (adenosine, cordycepin, and N 6 ‐2‐hydroxyethyl‐adenosine), cyclodepsipeptides, and polysaccharides (Olatunji, Tang et al, ; Wang et al, ; Zeng et al, ; Zhu, Zheng, Deng, Chen, & Zhang, ). N 6 ‐2‐hydroxyethyl‐adenosine (HEA; Figure ) is one of the major bioactive nucleosides present in C. cicadae and it possesses a wide variety of therapeutic activities such as antidiabetic, antiinflammation, Ca 2+ antagonist, sedative, analgesic, antitumor, and renoprotective properties (Li et al, ; Lu, Chen, Lee, Lin, & Kuo, ; Meng, Kang, Wen, Lei, & Hyde, ; Zheng et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Cordyceps cicadae is a medicinal parasitic fungus widely consumed as a functional food and medicine in many countries around Asia and especially China. In Chinese traditional medicine, C. cicadae has a long history of use as treatment for fever, convulsion, heart palpitation, and diabetes (Kuo et al, 2002;Olatunji, Tang et al, 2018;Zhang, Olatunji, Chen, Tola, & Oluwaniyi, 2018). C. cicadae is an interesting source of a number of bioactive compounds namely sterols (ergosterol and ergosterol peroxide), nucleosides (adenosine, cordycepin, and N 6 -2-hydroxyethyl-adenosine), cyclodepsipeptides, and polysaccharides (Olatunji, Tang et al, 2018;Wang et al, 2014;Zeng et al, 2014;Zhu, Zheng, Deng, Chen, & Zhang, 2014).…”

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N⁶ -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation

et al. 2018

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This study investigated the kidney‐protective ability of N6‐(2‐hydroxyethyl)‐adenosine (HEA) in alloxan‐induced diabetic rats. Diabetes was induced in the rats by the administration of alloxan monohydrate (150 mg/kg, i.p) and treated with HEA for 6 weeks. Diabetic rats displayed marked increase in blood glucose, serum creatinine (Scr), and blood urea nitrogen (BUN), in addition to high excretion of urinary protein and albumin. Furthermore, diabetic rats showed decreased renal levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and increased malondialdehyde (MDA) as well as renal concentrations of pro‐inflammatory mediators (TNF‐α, IL‐6, IL‐1β, and TGF‐β1). Treatment of diabetic rats with HEA (20 and 40 mg/kg) significantly increased the renal antioxidant level, reduced the levels of blood glucose, Scr, BUN, urinary protein, albumin, and pro‐inflammatory mediators in a dose‐dependent fashion. Histological evaluation of the kidney of diabetic rats indicated that HEA also ameliorated glomerular and tubular changes. Practical applications HEA is a bioactive constituent isolated from Cordyceps cicadae and has been shown to possess antihyperglycemic, kidney protective, antioxidant, and antiinflammatory effects in diabetic rats. HEA stimulated the antioxidant enzymes’ activities in the kidney tissues as well as reduced pro‐inflammatory mediators, indicating its antidiabetic and renoprotective effects in diabetic models. The results showed that HEA attenuated oxidative stress and inflammation in kidney tissues.

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The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology

Cited by 128 publications

References 168 publications

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

N⁶ -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation

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The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology

Cited by 128 publications

References 168 publications

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage.

Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

N6 -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation

Contact Info

Product

Resources

About

N⁶ -(2-hydroxyethyl)-adenosine from Cordyceps cicadae protects against diabetic kidney disease via alleviation of oxidative stress and inflammation