The genus Datura L. (Solanaceae): A systematic review of botany, traditional use, phytochemistry, pharmacology, and toxicology

Lian, Wenwen; Wang, Yuwei; Zhang, Jia; Yu, Yan; Xia, Changfa; Gan, He; Wang, Xiaoyan; Yang, Ting; Xu, Jiaming; He, Jun; Zhang, Weiku

doi:10.1016/j.phytochem.2022.113446

Cited by 7 publications

(3 citation statements)

References 106 publications

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“…Murtala et al (2023) determined that the LD 50 was greater than 2,000 mg/kg. According to Lian et al (2022) , typical lethal doses of Datura seeds ranging from 50 to 100 may have atropine. In the experiment, clinical manifestations such as decreased activity and lethargy, ataxia (loss of coordination), tremors or seizures, salivation and lacrimation (excessive salivation and tearing), mydriasis (dilated pupils), respiratory depression or difficulty breathing, diarrhea, coma, or death were observed ( Friedman, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

Rasool,

Nizamani,

Ahmad

et al. 2024

Front. Pharmacol.

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Background: Kashmir Himalaya hosts the most diverse and rich flora in the world, which serves as grazing land for millions of small ruminants in the area. While most plant species are beneficial, some can be poisonous, causing economic losses and animal health issues for livestock. Consequently, this study is the first comprehensive report on the traditional phyto-toxicological knowledge in District Muzaffarabad and the assessment of its authenticity through experimental studies in rats.Methods: The data regarding traditional knowledge was gathered from 70 key respondents through semi-structured interviews, which was quantitatively analyzed and authenticated through plant extract testing on Wistar female rats and comparison with published resources.Results: A total of 46 poisonous plant species belonging to 23 families and 38 genera were reported to be poisonous in the study area. Results revealed that leaves were the most toxic plant parts (24 species, 52.1%), followed by the whole plant (18 species, 39.1%), stem (17 species, 36.9%), and seeds (10 species, 21.7%). At the organ level, liver as most susceptible affected by 13 species (28.2%), followed by the gastrointestinal tract (15 species, 32.6%), nervous system (13 species, 8.2%), dermis (8 species, 17.3%), renal (7 species, 15.2%), respiratory (4 species, 8.7%), cardiovascular system (3 species, 6.5%), and reproductive system (2 species, 4.3%). The poisonous plant species with high Relative frequency citation (RFC) and fidelity level (FL) were Nerium oleander (RFC, 0.6; FL, 100), Lantana camara (RFC, 0.6; FL, 100), and Ricinus communis (RFC, 0.6; FL, 100). Experimental assessment of acute toxicity assay in rats revealed that Nerium oleander was the most toxic plant with LD50 of (4,000 mg/kg), trailed by Ricinus communis (4,200 mg/kg), L. camara (4,500 mg/kg), and Datura stramonium (4,700 mg/kg); however, other plants showed moderate to mild toxicity. The major clinical observations were anorexia, piloerection, dyspnea, salivation, tachypnea, constipation, diarrhea, tremor, itchiness, and dullness.Conclusion: This study showed that numerous poisonous plants pose a significant risk to the livestock industry within Himalayan territory, leading to substantial economic losses. Consequently, it is of utmost importance to conduct further comprehensive studies on the phytotoxicity of plants.

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Section: Discussionmentioning

confidence: 99%

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

Rasool,

Nizamani,

Ahmad

et al. 2024

Front. Pharmacol.

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“…In addition, the pharmacological properties of XBW, which encompass multiple components, targets and pathways, not only significantly increase FAO but also improve myocardial oxygen delivery through multiple mechanisms, thereby counteracting the drawbacks associated with increased FAO leading to increased myocardial oxygen consumption. For example, Yangjinhua in XBW can improve blood flow velocity and increase oxygen delivery [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism

Pan,

Xu,

Wen

et al. 2024

Chin Med

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Background Heart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. Xinbao Pill (XBW), a traditional Chinese medicine formulation integrating “Liushen Pill” and “Shenfu Decoction,” has been approved by China Food and Drug Administration for the treatment of HF for many years. The present study reveals a novel mechanism of XBW in HF through modulation of cardiac energy metabolism. Methods In vivo, XBW (60, 90, 120 mg/kg/d) and fenofibrate (100 mg/kg/d) were treated for six weeks in Sprague–Dawley rats that were stimulated by isoproterenol to induce HF. Cardiac function parameters were measured by echocardiography, and cardiac pathological changes were assessed using H&E, Masson, and WGA staining. In vitro, primary cultured neonatal rat cardiomyocytes (NRCMs) were induced by isoproterenol to investigate the effects of XBW on myocardial cell damage, mitochondrial function and fatty acid energy metabolism. The involvement of the SGLT1/AMPK/PPARα signalling axis was investigated. Results In both in vitro and in vivo models of ISO-induced HF, XBW significantly ameliorated cardiac hypertrophy cardiac fibrosis, and improved cardiac function. Significantly, XBW improved cardiac fatty acid metabolism and mitigated mitochondrial damage. Mechanistically, XBW effectively suppressed the expression of SGLT1 protein while upregulating the phosphorylation level of AMPK, ultimately facilitating the nuclear translocation of PPARα and enhancing its transcriptional activity. Knockdown of SGLT1 further enhanced cardiac energy metabolism by XBW, while overexpression of SGLT1 reversed the cardio-protective effect of XBW, highlighting that SGLT1 is probably a critical target of XBW in the regulation of cardiac fatty acid metabolism. Conclusions XBW improves cardiac fatty acid energy metabolism to alleviate HF via SGLT1/AMPK/PPARα signalling axis.

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“…Entire parts of the plant are fatal and the seeds are the most agile.The poisoning symptoms included dehydration of the mouth and extreme thirst, drouth of the skin, diminish vision, urinary detention,speedy heartbeat, puzzlement, nervousness, hallucinations, and loss of responsiveness (Das, Kumar, & Basu, 2012).The phytochemicals present in the studied plant were included in many psycopharmacologies because of their different anticholinergic activities (Shagal, Modibbo, & Liman, 2012). Pharmacological activities of the extracts in different solvents and phyto compounds have diverse activity like antitumor, antiinflammation, antioxidant, antimicrobial, antispasmodic, anticoagulant, analgesic, hypoglycemic and xanthine oxidase inhibitory and as well as the effects on central nervous system and immune system (Lian et al, 2022). At a therapeutic dose of 0.05 to 0.1 g of plant extract have anticancer effect against human epidermal carcinoma.…”

Section: Plant Appearancementioning

confidence: 99%

A comparative investigation of bioactive compounds present in Datura stramonium L. leaves extract in various solvents (ethanol, aqua, and ether) using TLC, IR, and GC-MS analytical techniques

Sangeetha,

Stella

2024

Acta Sci. Biol. Sci.

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The present study is an experimental comparative investigation of the biomolecules present in ethanol, aqua and ether extract of Datura stramonium L. leaves. The purpose of the study is to monitor the phytochemical constituents in the plant leaves by thin layer chromatography (TLC), Gas Chromatography-Mass Spectrometry (GC-MS), and infrared spectroscopy analytical techniques. The Datura Stramonium L. leaves were collected, dried and was extracted with ethanol, water and ether at room temperature. A comparative investigation of bioactive compounds have been carried out using TLC, GC-MS, and IR Analytical techniques. Preliminary phytochemical analysis revealed the presence of protein, alkaloid, phenol and tannins, flavanoid, glycoside, sterols, saponin, resins, anthocyanin, and carboxylic acid. More number of bio active phytochemicals were identified, and the chromatograph showed peaks of individual compounds. The result of this study offers a platform for understanding the Phytochemical present in ethanol, aqua and ether extract of studied plant leaves and to identify them as herbal alternative for various diseases and it can be used as functional pharmaceutical when once it extracted and treated carefully.

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The genus Datura L. (Solanaceae): A systematic review of botany, traditional use, phytochemistry, pharmacology, and toxicology

Cited by 7 publications

References 106 publications

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism

A comparative investigation of bioactive compounds present in Datura stramonium L. leaves extract in various solvents (ethanol, aqua, and ether) using TLC, IR, and GC-MS analytical techniques

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