The genus<i>Capsicum</i>: a phytochemical review of bioactive secondary metabolites

Antonio, Ananda da Silva; Wiedemann, Larissa Silveira Moreira; Veiga, Valdir Florêncio da

doi:10.1039/c8ra02067a

Cited by 110 publications

(85 citation statements)

References 199 publications

(542 reference statements)

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“…19,21,22 Those metabolites can be efficiently used due to their pungency, which can be defined as the ability to cause an irritation in the terminal nerves, producing pain and heat sensation. 33 This characteristic is caused by their interaction with the transient receptor potential vanilloid-1 (VR1), a neural receptor which, in summary, responses to temperature changes creating a sensation of heat or pain. 33,34 As the VR1 is a nonselective cation channel, it can be readily activated by proton sites present in different molecules, which are usually classified as vanilloids or non-vanilloids substances.…”

Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

“…33 This characteristic is caused by their interaction with the transient receptor potential vanilloid-1 (VR1), a neural receptor which, in summary, responses to temperature changes creating a sensation of heat or pain. 33,34 As the VR1 is a nonselective cation channel, it can be readily activated by proton sites present in different molecules, which are usually classified as vanilloids or non-vanilloids substances. 34,35 Metabolites that contain the vanillyl moiety, amide functions, triprenyl phenols and unsaturated dialdehyde sesquiterpenes had demonstrated to act as agonists of the VR1, being capable to produce a certain degree of pungency.…”

Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

“…These regions provide them an amphiphilic behavior, which allows their attachment to the VR1, without suffering cleavage, enabling its down regulation or desensitization. 33,34 The three botanical genera previously cited include the most famous pungent food additives, however, it must become clear that they are not the only options among the worldwide flora that could be used in the formulation of NLW. There are other genera and species that could provide an efficient and less toxic formulation, though the controversy of this topic avoids the technological improvement and discovery of natural product as chemical weapons.…”

Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

“…43 Among them, capsaicin and dihydrocapsaicin are considered the major ones, comprising from 89 to 98% of the total CAPS concentration in Capsicum fruits. 33 It is worth mentioning that the total CAPS concentration may vary from 0.003 to 1% of the total fruit weight, depending on the species, life cycle, environmental conditions of cultivation and geographical distribution. 33,[44][45][46][47] The concentration of capsaicinoids in each species is closely linked to the process of evolution and adaptation of these to the ecosystem, since the alkaloids of this class act in the defense mechanisms of the plant against arthropods.…”

Section: The Genus Capsicummentioning

confidence: 99%

“…33 It is worth mentioning that the total CAPS concentration may vary from 0.003 to 1% of the total fruit weight, depending on the species, life cycle, environmental conditions of cultivation and geographical distribution. 33,[44][45][46][47] The concentration of capsaicinoids in each species is closely linked to the process of evolution and adaptation of these to the ecosystem, since the alkaloids of this class act in the defense mechanisms of the plant against arthropods. [48][49][50] In this way, there is a great variability in the contents of capsaicinoids in Capsicum species (Table 1), including the non-pungent ones.…”

Section: The Genus Capsicummentioning

confidence: 99%

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Perspectives and Applications of Natural Products as Civilian Defense Devices

Antonio¹,

Fonseca²,

Mendes³

et al. 2019

J. Braz. Chem. Soc.

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Civilian defense devices are physical and chemical artefacts used to incapacitate an aggressor without causing death or injury. As city violence increases, safety feelings became worst and a growing commercial demand for these materials supply faces technologically challenges not only to riot control but also to self-protection. Controversies on the use of these devices have been discussed, especially on their toxicity when synthetic chemical agents are used. Natural metabolites are a less explored alternative to meet this demand. They have the capacity to generate a temporary disabling effect due to their pungency. Those metabolites, which include capsaicinoids, gingerols and piperine, can be used as deterrent agents in civilian defense devices due to their low toxicity to humans. Although they are a viable alternative, there are few studies focused on their quality control, efficiency and toxicity. This review aimed to present relevant aspects about the development and use of natural products as deterrent agents in self-defense devices against aggressors and animals, and as non-lethal weapons for riot control in order to help the scientific development of this type of bioproduct. was a member of the CAPES and Brazilian pharmacopoeia committees and has published 143 articles in specialized magazines, 13 patents and 38 book chapters, with 50 thesis and dissertations supervised.

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Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

Section: Natural Products Application In Defense Devicesmentioning

confidence: 99%

Section: The Genus Capsicummentioning

confidence: 99%

Section: The Genus Capsicummentioning

confidence: 99%

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Perspectives and Applications of Natural Products as Civilian Defense Devices

Antonio¹,

Fonseca²,

Mendes³

et al. 2019

J. Braz. Chem. Soc.

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Genetic, Epigenetic, and Hormonal Regulation of Fruit Development and Ripening inCapsicumL. Species

Kumar

Kumar²,

Anju

et al. 2021

Annual Plant Reviews Online

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Fruits are not only important for the plants but also for ensuring sustainable food security of the burgeoning global population. Considering the huge nutritional and ecological importance of fruits, investigation of mechanisms, and factors governing their development and ripening is crucial. The investigation of fruit development in several economically important crops such as tomato, strawberry, grape, and banana includingCapsicumsuggest that early fruit development is largely dependent on auxins and gibberellins (GAs) whereas later ripening is dependent on ethylene or abscisic acid (ABA). The initial development is relatively conserved whereas the ripening of fruits can be either climacteric or non‐climacteric depending on the presence or absence of respiratory burst and ethylene production respectively. Climacteric fruit ripening is mediated by ethylene, and it is well studied in tomato and banana, whereas non‐climacteric fruit ripening requires ABA and much of the information on it comes from strawberry and grape. The genusCapsicumL. shows rich diversity in fruit traits such as shape, colour, size, and even in its ripening behaviour. Early fruit development in different species ofCapsicumappears similar to other fruit crops, whereas later fruit ripening behaviour in different species ofCapsicumcan be either climacteric or non‐climacteric depending upon evolution of ethylene and respiratory burst. It has been found that, even different cultivars of the same species ofCapsicumshow variation in ripening behaviour suggesting interspecific and intraspecific complexities in fruit ripening responses. Until a few years, a majority of the papers have focussed on the non‐climacteric nature of fruit ripening inCapsicum. However, recent studies have shown substantial involvement of ethylene and ethylene related genes in fruit ripening ofCapsicumsuggesting the existence of extensive common regulons between climacteric and non‐climacteric fruits. Recent studies have also suggested the involvement of several epigenetic mechanisms such as non‐coding RNAs (ncRNAs) and cytosine methylation in regulating fruit development and ripening. With the advent of new tools in the omics field such as genomics, transcriptomics, metabolomics, and epigenomics, there is considerable progress in understanding the fruit development and complex nature of ripening inCapsicum. Nevertheless, consolidated information onCapsicumfruit development and its complex nature of ripening is not available. In this article, an attempt is made to present up to date consolidated information on the development and ripening ofCapsicumfruit with an emphasis on its genetic, epigenetic, and hormonal regulation.

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What Do We Know About Capsicum Volatilome?

Ithaí Ángeles‐López,

José Martínez‐Cano,

Villa‐Ruano

2024

Chemistry & Biodiversity

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The Capsicum genus includes several cultivated species that release complex blends of volatile organic compounds (VOCs) associated with their unique aroma. These VOCs are essential info‐chemicals in ecological interactions. In this review, we describe how the volatilomic profiling naturally varies based on specific plant organs and genotypes as well as how non‐beneficial organisms affect VOCs biosynthesis and accumulation in pepper plants. Also, we show evidence about VOCs variation under the pressure of different abiotic factors such as water stress, soil type and nutrient availability. The contribution of specific metabolic pathways and gene expression related to the biosynthesis of particular VOCs is addressed. We highlighted the utility of VOCs as chemical markers for quality control in the food industry, breeding programs to generate resistant plants and to improve aroma innovation. Herein we present a database containing 2734 VOCs, revealing 113 as the basic core of the volatilome from five Capsicum species.

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The genusCapsicum: a phytochemical review of bioactive secondary metabolites

Abstract: TheCapsicumgenus is economically important due to its chemical profile which is rich in capsaicinoids, carotenoids and flavonoids. Its unique chemical composition allows this genus to be applied from food additives to medicinal application.

Cited by 110 publications

References 199 publications

Perspectives and Applications of Natural Products as Civilian Defense Devices

Perspectives and Applications of Natural Products as Civilian Defense Devices

Genetic, Epigenetic, and Hormonal Regulation of Fruit Development and Ripening inCapsicumL. Species

What Do We Know About Capsicum Volatilome?

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