The Genus <i>Plectranthus</i> in India and Its Chemistry

Waldia, Shobha; Joshi, B. C.; Pathak, Uma; Joshi, Mukesh C.

doi:10.1002/cbdv.201000048

Cited by 32 publications

(19 citation statements)

References 33 publications

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“…Coleus forskohlii ; Lamiaceae) but was undetectable in leaf and root extracts of P. caninus Roth (syn. Coleus caninus ), which is consistent with the published occurrence of 13 in the genus Plectranthus (Waldia et al, 2011). The anti-cancer agent paclitaxel (taxol ® ) ( 1 ) (Kingston, 2007) was detected in extracts from Taxus x media cell suspension cultures.…”

Section: Resultssupporting

confidence: 91%

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

et al. 2013

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We report the development and testing of an accurate mass – time (AMT) tag approach for the LC/MS-based identification of plant natural products (PNPs) in complex extracts. An AMT tag library was developed for approximately 500 PNPs with diverse chemical structures, detected in electrospray and atmospheric pressure chemical ionization modes (both positive and negative polarities). In addition, to enable peak annotations with high confidence, MS/MS spectra were acquired with three different fragmentation energies. The LC/MS and MS/MS data sets were integrated into online spectral search tools and repositories (Spektraris and MassBank), thus allowing users to interrogate their own data sets for the potential presence of PNPs. The utility of the AMT tag library approach is demonstrated by the detection and annotation of active principles in 27 different medicinal plant species with diverse chemical constituents.

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Section: Resultssupporting

confidence: 91%

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

et al. 2013

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“…2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.…”

Section: Introductionmentioning

confidence: 75%

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Ávila¹,

Pinto²,

Sousa³

et al. 2016

J. Braz. Chem. Soc.

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Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains. Keywords: Plectranthus ornatus, diterpenes, ent-clerodanes, bacteriostatic IntroductionThe genus Plectranthus L'Her (Lamiaceae, subfamily Nepetoideae, tribe Ocimeae, subtribe Plectranthinae) comprises approximately 300 species largely distributed over the African, Asian and Australian continents. 1 Plectranthus is a large genus well known by its diversity of ethnobotanical uses, being especially indicated to treat digestive disorders, skin diseases, infections and respiratory problems. 2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.Plectranthus ornatus Codd (syn. Coleus comosus Hochst. ex Gurke) is a perennial and aromatic herb, widespread around the new world. 9 In the northeast of Brazil, P. ornatus, popularly known as "malva santa" or "boldo miúdo", is cultivated as a very important medicinal plant, indicated as analgesic and particularly to treat gastric disorders. 10 Several antimicrobial labdanes, ent-clerodanes, and halimane-type diterpenoids have been previously isolated from P. ornatus. 11 As part of a multidisciplinary program, where the efforts are devoted to study medicinal plants or congeners, in order to unveil their pharmacological or biological properties, herein we describe the isolation and characterization of five new diterpenes derivatives together with six known compounds from the aerial parts of cultivated specimens of P. ornatus, as well as the results of pharmacological and biological assays with the isolated secondary metabolites (Figure 1). Ávila et al. 1015 Vol. 28, No. 6, 2017 Experimental General experimental proceduresOptical rotations were measured on a PerkinElmer 341 digital polarimeter. Infrared (IR) spectra were obtained on a PerkinElmer FT-IR spectrum 1000 spectrometer. Accurate mass spectra were acquired on a liquid chromatography-mass spectrometry ion-trap and time-of-flight (LCMS-IT-TOF, Shimadzu) spectrometer. Nuclear magnetic resonance (NMR) spectra were performed either on Bruker DPX-300 or DRX-500 spectrometers. Open column chromatography (CC) were carried out wit...

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“…The other two are from different parts of Africa, Asia, and Europe. All of them have been used to treat digestive and hepatic dysfunctions (Brandolt et al, 2007;Rosal, 2008;Viana et al, 2010;Rosal et al, 2011;Waldia et al, 2011;Pontes et al, 2012;Lima, 2017;Lima et al, 2017). Therefore, those species may be approached by different point of view.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of a Practical Activity in the Construction of Knowledge of the Concepts of Species and Phenotypic Plasticity Using the Boldo Mirim (<i>Plectranthus neochilus</i> Schltr.)

Lima¹,

Sodré²,

Lima³

et al. 2017

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The analyses efficacy of a practical activity addressing the measure of morphological characteristics of Boldo Mirim (Miniature Boldo), (Plectranthus neochilus Schltr.) which were cultivated in two conditions of solar intensity (50% and 100%), involved two professors and 7 students who participated at different ways in planning, performing and evaluating the results. This activity was carried out in 49 students matriculated in the discipline Botany II of 1st semester of the Biological Sciences course of UFF. The objective of the present study was to foment the construction of a significant learning about concept of specie and phenotypic plasticity. To perform the measurements on the leaves: 1) the foliar areas by two methods (weigh and counting); 2) the internode distance; and 3) the presence of trichome, two types of papers (baking and millimetric) and basic equipment such as manual calibration caliper (mm), precision analytical balance (0.001 g) and a monocular stereoscope (40×) were provided. It was verified that with the reduction in the availability of solar light, the Boldo Mirim increases its leaf area and the distance internodes for the best use of the luminosity in the photosynthetic process, whereas in conditions of full sunshine this plant invests less in leaf area and reduces the distance between leaves that are practically superimposed to avoid stress due to excess of light. After following the proposed protocol, the questionnaire with 12 questions about the plant's characteristics, the concepts of Creative Education species and of phenotypic plasticity, and the effectiveness of the practical activity were applied to the 14 groups of 3 to 4 students from the total of 49 ones. The correlation coefficients obtained from the comparison of the two methods used to measure the foliar area (weight and counting) was positive and significant for Branch type 1 (from plant raised at 100% of solar intensity: r = 0.806, n = 10; p ≤ 0.005) and for Branch type 2 (from plant raised at 50% of solar intensity: r = 0.755, n = 10; p ≤ 0.005) as well. These results revealed that the proposal of the practice reached its goals. However, the critics of the 49 target students fell mainly on the restriction of the available time to the practical activity. In conclusion, the activity involvement revealed that the practical activity achieved its purpose. Thus, all the 56 students involved were able to construct the knowledge about the scientific methods, the concepts of species and phenotypic plasticity, and the therapeutic applicability of the Mirim Boldo, within a critical vision of the teaching-learning process.

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The Genus Plectranthus in India and Its Chemistry

Cited by 32 publications

References 33 publications

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

The Efficacy of a Practical Activity in the Construction of Knowledge of the Concepts of Species and Phenotypic Plasticity Using the Boldo Mirim (<i>Plectranthus neochilus</i> Schltr.)

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The Genus Plectranthus in India and Its Chemistry

Cited by 32 publications

References 33 publications

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

The Efficacy of a Practical Activity in the Construction of Knowledge of the Concepts of Species and Phenotypic Plasticity Using the Boldo Mirim (&lt;i&gt;Plectranthus neochilus&lt;/i&gt; Schltr.)

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The Efficacy of a Practical Activity in the Construction of Knowledge of the Concepts of Species and Phenotypic Plasticity Using the Boldo Mirim (<i>Plectranthus neochilus</i> Schltr.)