The Genus Klebsiella

Brisse, Sylvain; Grimont, Francine; Grimont, Patrick A. D.

doi:10.1007/0-387-30746-x_8

Cited by 147 publications

(169 citation statements)

References 404 publications

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“…K. pneumoniae, particularly when hypermucoid, can cause invasive disease in several animal species (8,9) and is a common cause of mastitis in dairy herds (10). Moreover it can thrive in a range of plant hosts and environmental niches, including water, soil, and plant matter (4,5,11). Although it is clear that K. pneumoniae is genetically and phenotypically diverse (12,13), previous efforts to identify specific features that can distinguish human clinical isolates from plant, animal, or environmental isolates have yielded no markers of humanspecific lineages (14).…”

Section: Significancementioning

confidence: 99%

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Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Holt

Wertheim

Zadoks

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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1,042

1,123

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Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more than 300 human and animal isolates spanning four continents. Our data provide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K. variicola). Further, for K. pneumoniae (KpI), the entity most frequently associated with human infection, we show the existence of >150 deeply branching lineages including numerous multidrug-resistant or hypervirulent clones. We show K. pneumoniae has a large accessory genome approaching 30,000 protein-coding genes, including a number of virulence functions that are significantly associated with invasive community-acquired disease in humans. In our dataset, antimicrobial resistance genes were common among human carriage isolates and hospital-acquired infections, which generally lacked the genes associated with invasive disease. The convergence of virulence and resistance genes potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-genome framework against which to track the emergence of such threats.

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Section: Significancementioning

confidence: 99%

“…Widely considered an opportunistic pathogen, K. pneumoniae can be carried asymptomatically in the intestinal tract, skin, nose, and throat of healthy individuals (4,5) but can also cause a range of infections in hospitalized patients, most commonly pneumonia, wound, soft tissue, or urinary tract infections.…”

mentioning

confidence: 99%

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Holt

Wertheim

Zadoks

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

1,042

1,123

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“…: Similarly, colonies of Fecal coliforms were isolated from the mid-VRBL and sown on the mid-Eosin Methylene Blue (EMB), after their incubation at 37°C, for 48 h [10]. The Klebsiella colonies have shown large, rounded and very mucous membranes [11].…”

Section: Enumeration Of the Total Aerobic Mesophilic Flora (Tamf)mentioning

confidence: 99%

Microbiological Study of Turkey Meat Marketed in Kenitra (North-oust of Morocco)

Jaber¹,

Ijoub²,

Zaher³

et al. 2017

J Nutr Food Sci

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Turkey meat is considered among meat of poultry most consumed by the Moroccan population, and this due to its richness in vitamins, proteins and essential elements for growth, which gives him an excellent nutritional value. In addition, it is characterized by a low content of fatty acids. But this highly perishable commodity could constitute a real danger of food-borne illness. The aim of present study is to assess the hygienic quality of 168 samples collected from twenty four points of sales located in six neighborhoods in Kenitra. The analysis of the microbiological quality of the samples shows that the percentage of non-compliance for the parameter Total Aerobic Mesophilic Flora is 35%, with the mean concentration 7.21 (log 10 cfu/g). The respective percentages of non-compliance of the total and fecal coliforms are 68 and 75% with bacterial concentrations 6.69 (log 10 cfu/g) and 6.42 (log 10 cfu/g). This non-compliance is due to the presence of the germs of fecal contamination among the identified isolates. The four identified species showed following prevalence: Escherichia coli (67.9%), Klebsiella pneumonia (17, 9%), Pseudomonas sp. (14.1%) and Salmonella (0%).

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“…For this purpose, forty-five isolates of Klebsiella pneumoniae were recovered from burn wounds, urines, and respiratory tract of patients, 15, 20, 10 clinical specimens respectively, from patients by random. The isolates were identified by conventional biochemical and standard microbiology tests including colonial morphology (Eosin methylene blue, Macconkey agar 37c/24 hours) [12], TSI, SIM, and Simon citrate agar [13][14][15].…”

Section: Sampling and Bacteria Isolationmentioning

confidence: 99%

Evaluation of E492 Microcin Gene Presence in Klebsiella pneumoniae Collected from Patients Registered to Educational Hospitals of Isfahan

Nasr-Esfahani

Ahadi

Ayat

et al. 2017

Zahedan J Res Med Sci

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The Genus Klebsiella

Cited by 147 publications

References 404 publications

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

Microbiological Study of Turkey Meat Marketed in Kenitra (North-oust of Morocco)

Evaluation of E492 Microcin Gene Presence in Klebsiella pneumoniae Collected from Patients Registered to Educational Hospitals of Isfahan

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