The genus Rudbeckia: A critical review of its traditional medicinal uses, phytochemistry, and pharmacology

Vardeman, Ella; Lyles, James T.; Quave, Cassandra L.

doi:10.1016/j.hermed.2021.100530

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The maceration procedure can be sped up by powder texture. The material was macerated in ethanol 70% for 24 hours (Farida & Maruzy, 2016). The filtrate from maceration process was evaporated using rotary evaporator until it became a thick extract (Leorita et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Effects of NADPH oxidase inhibitor of the Etlingera elatior (E. elatior) fruits extracts in animal sepsis models

2024

Trop Biomed

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Infectious diseases with complications of sepsis are still public health concern in both developed and developing countries. Sepsis is a potentially life-threatening systemic immune response to infection that can lead to end-stage organ failure and death. Sepsis involves multiple mechanisms such as neuroendocrine, complement activation, blood coagulation, and fibrinolytic system. Reactive oxygen species (ROS) is an inflammatory mediator produced by NADPH oxidase activation. This study aimed to investigate the effects of ethanol extract of E. elatior fruits on NADPH oxidase activity. Forty Mus musculus mice were randomized divided into five groups (n=8), with the intervention group receiving an intraperitoneal injection of 0.3 mg/kg BW lipopolysaccharide (LPS). There was a normal group without LPS injection (N-1), LPS injection only (N-2), and those that received LPS injection and ethanol extracts of E. elatior fruits containing 2.1 mg/20 g (N-3), 4.2 mg/20 g (N-4), and 8.4 mg/20 g (N-5). NADPH oxidase activity were measured using ELISA. The oneway ANOVA was used to investigate the differences between the groups. After administration of the extract at a varied dose, N-5 group the lowest NADPH oxidase activity (p=0.001). The ethanol extract of E. elatior fruit has antioxidant effects. In this study, a dose of 8.4 mg/20 g of extract significantly reduced NADPH oxidase activity. The ethanol extract of E. elatior might be considered a treatment in sepsis.

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Section: Methodsmentioning

confidence: 99%

Effects of NADPH oxidase inhibitor of the Etlingera elatior (E. elatior) fruits extracts in animal sepsis models

2024

Trop Biomed

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“…The inflorescences and roots of the species also contain several classes of polyacetylenic and polyinic compounds, such as thiophenes, thiarubrines and tridecapentaynenes, with implications for the insecticidal properties observed in different extracts obtained from the plant [15,16]. Sesquiterpenes, representing the Asteraceae family, i.e., germacrene D, δ-cadinene and a pseudoguaianolidetype lactone-rudbeckolide, which showed potent 5-LOX inhibitory activity in vitro, were also isolated from the flowers of R. hirta [17,18].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Phytochemical and Biological Evaluation of Rudbeckia hirta Flowers

Burlec

Pecio

Mircea

et al. 2023

Plants

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Black-eyed Susan (Rudbeckia hirta L.), a flowering plant with various traditional medicinal uses, has recently garnered interest for its therapeutic properties. However, little is known about the potential therapeutic activities of the plant species. The current study focused on conducting a comprehensive investigation into the chemical composition and bioactivity of black-eyed Susan cultivated in Romania. Untargeted metabolite profiling and UHPLC-HR-MS phytochemical analysis of the studied extract revealed the presence of more than 250 compounds pertaining to different classes, including sesquiterpene lactones, polyphenolic acids, flavonoids, amino acids, and fatty acids. The tested extract exhibited inhibitory activity against Gram-positive bacteria and showed promising antifungal activity. It also demonstrated potent antioxidant properties through iron chelation and 15-LOX inhibition capacities, as well as inhibition of cell growth, particularly on the MCF-7 cell line, suggesting potential anticancer effects. Therefore, current research provides valuable information on the antioxidant, antimicrobial, and antitumor potential of Rudbeckia hirta flowers. Implicitly, the discovery of such a wide range of biosubstances, together with the biological activity observed for the studied extract in these preliminary in vitro studies, paves the way for future investigation of the potential application of the plant in the pharmaceutical and nutraceutical sectors.

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“…The Rudbeckia genus generally includes mostly perennial and sometimes biennial or annual herbs. Species from this genus have long been used by natives as food and medicine especially in North America, with applications ranging from snakebite treatment to gynaecological disorders aid [25]. Rudbeckia hirta, in particular, has been widely included in the traditional medicine, given its properties and great geographic range.…”

Section: Introductionmentioning

confidence: 99%

“…Rudbeckia hirta, in particular, has been widely included in the traditional medicine, given its properties and great geographic range. It has been used for its analgesic, anthelmintic, antimicrobial and ornamental properties, as well as a snakebite remedy, heart, digestive and kidney medicine [9,25]. Tagetes erecta L. is another well-known plant of the Asteraceae family and can be easily found in most parts of South America.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition and in Vitro Biological Properties of Several Rudbeckia Hirta and Tagetes Erecta Flower Extracts

BURLEC¹

2022

FARMACIA

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The present research focuses on the investigation of the phytochemical profile and biological properties of two ornamental species from the Asteraceae family. Taking into consideration that certain compounds found in such plants can be used as valuable resource for the pharmaceutical and cosmetic industries, we chose to examine the chemical profile in correlation with the biological activities of Rudbeckia hirta and Tagetes erecta flower extracts. Three types of extracts were obtained for each plant product, using solvents with different polarities. Secondary metabolites found in the extracts, such as polyphenols and flavonoids (e.g., caffeic, chlorogenic and gentisic acids, patuletin, quercetin, quercetagetin, quercetagitrin) were quantitatively analysed using HPLC-MS methods. The studied compounds were found to be present in most of the analysed samples in variable quantities, with the highest quantities being found in the ethanolic plant extracts. Positive dose-related values revealed that the investigated extracts exhibit good antioxidant activity through the three investigated mechanisms (ferric reducing capacity, superoxide radical scavenging capacity, hydroxyl radical scavenging capacity). Furthermore, all extracts showed promising antifungal and antibacterial activities, with Tagetes erecta extracts exhibiting better pronounced antibacterial activity, while the most promising antifungal action was observed for Rudbeckia hirta extracts. RezumatStudiul a urmărit investigarea profilului fitochimic și a proprietăților biologice a două specii ornamentale din familia Asteraceae. Având în vedere că anumiți compuși găsiți în astfel de plante pot fi utilizați ca resursă valoroasă pentru industria farmaceutică și cosmetică, am ales să studiem profilul chimic în corelație cu activitățile biologice ale extractelor obținute din flori de Rudbeckia hirta și Tagetes erecta. Pentru fiecare produs vegetal s-au obținut trei tipuri de extracte, utilizând solvenți cu polarități diferite. Metaboliții secundari găsiți în extracte, precum polifenolii și flavonoidele (acizii cafeic, clorogenic și gentizic, cvercetol, cvercetagetină, cvercetagitrină, patuletină), au fost analizați cantitativ folosind metode LC-MS. Compușii studiați s-au dovedit a fi prezenți în majoritatea probelor analizate în cantități variabile, cele mai mari concentrații regăsinduse în extractele etanolice. Valorile obținute în cadrul testării capacității antioxidante au arătat că extractele investigate prezintă o activitate antioxidantă bună prin toate cele trei mecanisme cercetate (capacitatea de reducere a ionului feric, capacitatea de chelatare a radicalului superoxid, capacitatea de chelatare a radicalului hidroxil). În plus, toate extractele au prezentat activități antifungice și antibacteriene promițătoare, extractele de Tagetes erecta prezentând o activitate antibacteriană mai bună, în timp ce acțiunea antifungică cea mai eficientă s-a observat pentru extractele de la Rudbeckia hirta.

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The genus Rudbeckia: A critical review of its traditional medicinal uses, phytochemistry, and pharmacology

Cited by 4 publications

References 35 publications

Effects of NADPH oxidase inhibitor of the Etlingera elatior (E. elatior) fruits extracts in animal sepsis models

Effects of NADPH oxidase inhibitor of the Etlingera elatior (E. elatior) fruits extracts in animal sepsis models

Preliminary Phytochemical and Biological Evaluation of Rudbeckia hirta Flowers

Phytochemical Composition and in Vitro Biological Properties of Several Rudbeckia Hirta and Tagetes Erecta Flower Extracts

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