The genus Scutellaria an ethnopharmacological and phytochemical review

Shang, Xiaofei; He, Xirui; He, Xiaoyun; Li, Maoxing; Zhang, Ruxue; Fan, Pengcheng; Zhang, Quanlong; Jia, Zhengping

doi:10.1016/j.jep.2010.01.006

Cited by 342 publications

(287 citation statements)

References 119 publications

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“…Based on these results and literature reports of compounds known to be in other Scutellaia spp. (Shang 2010), it was confirmed that the compounds are wogonin (mw 284, 2), and neobaicalein (mw 374, 1).…”

Section: Identifi Cation Of Individual Chemical Constituents In S LImentioning

confidence: 86%

“…The major differences between the chemical structures are the presence and position of hydroxyl and methoxy groups. Previous studies involving baicalein and wogonin showed that these compounds influence multiple cellular processes (Shang et al, 2010;Wakabayashi & Yasui, 2000;Hui et al, 2002). In contrast, little is known about the activities of 6-hydroxyflavone and neobaicalein.…”

Section: Discussionmentioning

confidence: 99%

“…Scutellaria, Lamiaceae, is a genus of about 300 species of plants (Mabberley, 1993) and has been used as traditional medicine in China, India, Korea, Japan, Europe and North America (Shang et al, 2010). Scutellaria spp.…”

Section: Introductionmentioning

confidence: 99%

“…possesses effective anticancer activity and this property is due to some fl avones such as baicalin, baicalein and wogonin (Li-Weber, 2009). Scutellaria extracts are not only cytostatic but also cytotoxic in vitro and in vivo (Scheck et al, 2006;Shang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

Tayarani-Najarani¹,

Asili²,

Parsaee³

et al. 2012

Rev. bras. farmacogn.

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Chemical investigation on the CH 2 Cl 2 fraction of the Scutellaria litwinowii Bornm. & Sint., Lamiaceace, root extract for the fi rst time resulted in the isolation of wogonin, and neobaicalein. These compounds were evaluated for their cytotoxicity towards HeLa cell lines and lymphocytes. Meanwhile, the role of apoptosis was explored in this toxicity. The cells were cultured in RPMI medium and incubated with different concentrations of isolated fl avonoids. Cell viability was quantifi ed by MTS assay. Apoptotic cells were determined using propidium iodide staining of DNA fragmentation by fl ow cytometry (sub-G1peak). Wogonin, and neobaicalein inhibited the growth of malignant cells in a dose-dependent manner. The IC50 values of 46.62 and 79.34 µM were, respectively, found for neobaicalein and wogonin against HeLa cells after 48 h of treatment. Neobaicalein induced a sub-G1 peak in the fl ow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in neobaicalein toxicity. Neobaicalein exerts cytotoxic and pro-apoptotic effects in HeLa cell lines and could be considered as a potential chemotherapeutic agent in cancer treatment.

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Section: Identifi Cation Of Individual Chemical Constituents In S LImentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

Tayarani-Najarani¹,

Asili²,

Parsaee³

et al. 2012

Rev. bras. farmacogn.

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“…Radix Scutellariae (RS) is the dried root of the Labiatae plant Scutellaria baicalensis Georgi and it is officially listed in the Chinese Pharmacopoeia and has been extensively employed in various proprietary traditional Chinese medicines indicated for inflammation and infections (Shang et al, 2010). Flavonoids are abundant in RS and six flavones are identified to be its major ingredients, namely baicalein (B), baicalin (BG), wogonin (W), wogonoside (WG), oroxylin A (OA) and oroxylin A-7-glucuronide (OAG) (Li et al, 2009;Li & Sheu, 1995) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones inRadix Scutellariaeand potential pharmacological impact

Fong²,

Mei

et al. 2013

Pharmaceutical Biology

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, whereas their percentage of metabolism was decreased from 72.75 AE 2.44%, 73.27 AE 3.25% and 89.84 AE 2.99% to 21.11 AE 0.69%, 17.90 AE 5.55% and 45.44 AE 3.38%. PGE 2 level was much lower in the co-administration group (49.04 AE 2.03 pg/ml) than in the MEF group (73.13 AE 3.03 pg/ml) or RS group (494.37 AE 11.75 pg/ml) 4 h post MEF dosing, suggesting a synergic effect. Discussion and conclusion: Co-administration of MEF and RS could induce potential alterations in their pharmacokinetic profiles and anti-inflammatory effects.

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Can there be an Ethnopharmacology of Inflammation?

Heinrich¹,

Booker²

2015

Ethnopharmacology

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The genus Scutellaria an ethnopharmacological and phytochemical review

Cited by 342 publications

References 119 publications

Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells

Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones inRadix Scutellariaeand potential pharmacological impact

Can there be an Ethnopharmacology of Inflammation?

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