The Geographic Origin of Helicobacter pylori Influences the Association of the
            <i>homB</i>
            Gene with Gastric Cancer

Kang, Jin Kyung; Jones, Kathleen R.; Jang, Sungil; Olsen, Cara; Yoo, Yun‐Jung; Merrell, D. Scott; Heon, Jeong

doi:10.1128/jcm.06293-11

Cited by 25 publications

(53 citation statements)

References 20 publications

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“…The s1/m1 or s2/m2 displays the genotype of i1 and i2, respectively, while the s1/m2 displays genotype of i1 or i2. The relationship between i genotype and disease is region dependent[21,22]. Both the S1 and S2 are not pathogenic.…”

Section: Polymorphisms Of H Pylori Virulence Genesmentioning

confidence: 99%

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

Chen¹,

Mo²,

Huang³

et al. 2016

WJG

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Helicobacter pylori (H. pylori) is a kind of chronic infectious pathogen which can cause chronic gastritis, peptic ulcer, gastric cancer and other diseases. The genetic structure of the pathogenic genes of H. pylori varies largely, which contributes to the differences in virulence among various strains, and in clinical symptoms. Virulence genes of H. pylori can be categorized into three main classes: those related to adhesion and colonization, those related to gastric mucosal injury, and others. This review focuses on the relationship between genetic polymorphisms of the three classes of virulence genes of H. pylori and diseases. Most of the genetic polymorphisms of the main virulence factors of H. pylori are summarized in this paper.

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Section: Polymorphisms Of H Pylori Virulence Genesmentioning

confidence: 99%

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

Chen¹,

Mo²,

Huang³

et al. 2016

WJG

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“…The large group of OMPs contains adhesins (BabA and SabA), adherence-associated lipoproteins (AlpA/B) and infl ammatory OMPs (OipA or HomB) that mediate H. pylori binding to the host cell membrane. Some of these OMPs are associated with more severe pathologies, such as HomB in ulcers [ 19 ] and cancer [ 10 ]. The babA genotype correlates with the highest incidence of ulceration and gastric cancer [ 24 ].…”

Section: H Pylori Virulence Factorsmentioning

confidence: 99%

Epidemiology of Helicobacter pylori and Mechanisms of Carcinogenesis

Lehours

Bessède

Mégraud

et al. 2015

Tropical Hemato-Oncology

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Soon after the discovery of H. pylori , numerous studies based on serological surveys highlighted an increasing prevalence of H. pylori infection with age within a population, which was inversely related to the socio-economic status [ 14 ]. This was related to the so-called cohort phenomenon: each age group has a different prevalence of an infection acquired primarily during childhood and lasting lifelong. The risk of acquiring the infection has decreased over the years due to improvement in socio-economic conditions.Regarding Europe, the prevalence of H. pylori infection according to the year of birth has decreased quickly and dramatically in countries from Northern Europe (e.g. Finland), whereas it remains high in some countries from Southern Europe (especially Portugal) [ 11 ]. Indeed, H. pylori infection remains a frequent and early event in Portugal [ 13 ].A gastric biopsy-based study conducted in the Brussels area (Belgium) over a 20-year period has also nicely shown that the prevalence was much higher in children (0-9 years old) with a North African origin compared to children with Western European origin. Therefore, these data show the effects of time, age and ethnicity on

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“…9,10 Another group of proteins that is highly variable between strains is the OMPs. [18][19][20][21][22][23] Unfortunately, we were unable to identify a definitive genotype that was indicative of disease progression; however, the observed association between homA/homB/homC and cagA, vacA and the bab subfamily led us to investigate the Hom OMP family in greater detail. Additionally, recent studies have proposed the necessity of OMPs for efficient delivery of CagA to the host cell.…”

mentioning

confidence: 96%

“…Each of these polymorphic regions is subsequently divided into two types (type 1 and type 2), and the type 1 variants are associated with higher cell toxicity and more severe disease outcome following H. pylori infection. [18][19][20][21][22][23] The culmination of those studies revealed two themes: (1) there is a high level of variation observed in the AH population as compared to the near homogenous profile of the KH population and (2) the OMP profile of a strain can be used as an indicator of its geographic origin. OMPs provide a key interface between Gram-negative pathogens and their environment and may serve as a genetic determinant of disease outcome.…”

mentioning

confidence: 99%

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Comparative analysis of the Hom family of outer membrane proteins in isolates from two geographically distinct regions: The United States and South Korea

Servetas

Kim

et al. 2018

Helicobacter

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En masse, our data show that the homA, homB, and homC profiles vary based upon the geographic origin of the strain; however, the fourth member of the hom family, homD, is more highly conserved. Additionally, protein topology modeling showed that many of the less well-conserved regions between homA and homB and between homC and homC corresponded to predicted environmentally exposed loops, suggesting that the divergence of the Hom family may be due to host adaptation/pressure.

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The Geographic Origin of Helicobacter pylori Influences the Association of the homB Gene with Gastric Cancer

Cited by 25 publications

References 20 publications

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

Epidemiology of Helicobacter pylori and Mechanisms of Carcinogenesis

Comparative analysis of the Hom family of outer membrane proteins in isolates from two geographically distinct regions: The United States and South Korea

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