A regional review of publicly available seismic reflection lines and wells enables the identification across the Midlands Microcraton (MMC) of four Paleozoic seismostratigraphic megasequences, bounded by the Shelveian, Acadian, Symon and Variscan unconformities. The southern boundary of the MMC is drawn at a line of major change in pre-Permian subcrop, and most of central southern England is considered underlain by Paleozoic rocks of MMC character. The Lower Silurian Shelveian Unconformity cuts down through Ordovician and Cambrian rocks to the Precambrian and largely defines the distribution of these rocks in the region. However, more than 2500 m of Tremadoc shales are preserved SW of Swindon. Above the Shelveian, a characteristic shallow-marine Silurian is overlain by up to 3000 m of Old Red Sandstone facies, preserved in a northsouth-orientated syncline. The Acadian Unconformity cuts down through folded Lower Paleozoic rocks, with the Frasnian transgression overlying Precambrian in places. Little Carboniferous was deposited across the MMC until uppermost Westphalian-Stephanian Warwickshire Group sandstones and coals were laid down across the erosion surface of the Symon Unconformity. The northern boundary of thin-skinned Variscan thrusting can be interpreted on seismic data but appears to have had little effect on the regional pre-Permian subcrop.This paper presents the results of a regional review of the area of the Midlands Microcraton (MMC) using the digital, post-stack seismic lines, and well and borehole formation tops and times (Fig. 1), freely available to academic users through the UK Onshore Geophysical Library (UKOGL), together with lithological descriptions from released wells. This area has been of little interest for oil and gas exploration over the past 25 years, and the details of the Paleozoic rocks are not widely known. Few seismic lines have been recorded over the eastern and westernmost parts of the MMC, and lines recorded over the rest of the area vary greatly in vintage and quality. However, many of the lines in the central area show remarkably good detail of both Lower and Upper Paleozoic sequences and tectonic events. Interpretation has enabled the identification of four major unconformities, which define the distribution of Paleozoic rocks beneath the Permian and Triassic cover across the MMC. It has also enabled the recognition of a series of 'packages' of seismic character that can be used to identify the four seismostratigraphic megasequences separated by these unconformities. It is hoped that the information presented here will stimulate interest in the area and lead to more detailed studies for both commercial and academic purposes.