The role of transport infrastructure, especially railways, in shaping a nation's socio-economic and cultural dynamics is of paramount importance. The present research delves into the profound influence of the railway network on Iran's regional transformation, from its inception to present times. An in-depth historical evaluation uncovers the genesis and expansion of the Iranian railway system, linking it intricately with pivotal junctures in the nation's trajectory. Emphasis is placed on regions undergoing substantial developmental shifts, attributable to enhanced rail connectivity, offering distinct examples of varied growth paradigms. Economic repercussions manifest as interregional trade augmentation, resurgence of industries, and alterations in employment landscapes, thereby positing railways as an integral component of Iran's economic blueprint. Concurrently, an exhaustive scrutiny of socio-cultural realms underscores railways' pivotal role in fostering intercultural exchanges and expediting urbanisation trends. From an environmental perspective, the sustainability merits of rail transport are illuminated, accentuating the increasing pertinence of ecological considerations in railway's prospective expansion. Through meticulous case studies, a comparative narrative emerges between areas endowed with rail connectivity and those situated in relative isolation. The objective is to elucidate railways as instigators of transformative shifts. This study culminates with projections grounded in potential technological advancements poised to reshape Iran's railway infrastructure and the ensuing regional implications. Findings underscore railways' monumental impact on Iran's socio-economic fabric, illuminating their potential as change agents and offering invaluable insights for global infrastructure strategising.