The Gerbich Blood Group System, Especially in Melanesians

Booth, P.B.; McLoughlin, K.

doi:10.1159/000464486

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…A good example is Papua New Guinea where in some coastal parts of the country, up to 20% of the population may be Gerbich blood group negative (6) and the commonest IgG antibody detected is an Anti‐Gea. The second example of a Scianna null blood type (Sc:‐1,‐2) with Anti Sc3 present was also detected in this country and a study has shown the presence of numerous donors of this extremely rare type (7). Unfortunately, access to these donors is now not easy because of the difficult economic and social situation of this country.…”

Section: Really Rare Donorsmentioning

confidence: 60%

Rare Blood Donors: The Past and the Future

Woodfield

2002

Vox Sanguinis

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For many years, there has been a clinical requirement for the provision of units of rare blood for patients with either single or multiple blood group antibodies present. To co‐ordinate this need, the Rare Blood Donor Working Party of the International Society of Blood Transfusion was established in 1985. Since then, the Working Party has been active in promoting information on the procedures and methods for testing, packaging, transport and delivery of rare blood internationally. The Working Party has a close relationship with the Blood Group Reference Laboratory in the United Kingdom. The availability of the World Health Organization International Donor Panel permits the rapid and accurate locating of rare blood units. The Rare Blood Donor Working Party conducts surveys, attends to technical queries and is active in education. This can assist countries that are upgrading their blood services and give them a greater understanding of the international help available when confronted with a difficult‐to‐transfuse patient. In the future, it is anticipated that a wider range of countries will contribute to the International Donor Panel. It is likely that with the many major population movements throughout the world and the potential consequent development of rare antibodies or mixtures of antibodies, the need for the availability of rare blood donations will remain for the foreseeable future.

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Section: Really Rare Donorsmentioning

confidence: 60%

Rare Blood Donors: The Past and the Future

Woodfield

2002

Vox Sanguinis

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“…The frequency of Jk(a−b−) is 0·9%‐1·4% in Pacific Island populations but <0·1% in Caucasians . Furthermore, 10%‐50% of Melanesian populations are Ge− (Gerbich phenotype) .…”

Section: Rare Blood Types With Higher Frequencies In the Asia Pacificmentioning

confidence: 99%

Rare blood types in the Asia Pacific region

Tani

2016

ISBT Science Series

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Rare blood types are generally defined as those that occur at a frequency of 1 : 1000 or less. However, some rare blood types have much different frequencies in global regions or specific ethnic groups. This review explores rare blood types in the following categories: rare blood types that lack high‐frequency antigens and where to find them, rare blood types that express low‐frequency antigens, rare blood types with higher or lower frequencies in the Asia Pacific region and rare blood types that are difficult to find in the Asia Pacific region but are provided by the JRC. In addition, the study of rare blood types has revealed clinical correlations with disease states and resistance to infections.

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“…Two individuals,(P. L. and K. W.) with elliptocytic red cells, who apparently lack sialoglycoproteins /3, P/ and y, have recently been described (Anstee et al, 1984). The red cells of P. L. and K. W. lack the Gerbich blood-group antigen (Ge), absence of which is extremely rare except in certain areas of Papua-New Guinea (Race & Sanger, 1975;Booth & McLoughlin, 1972). Consequently, erythrocyte membranes from other Genegative individuals were tested to determine whether changes similar to those found in P. L. and K. W. were also present.…”

mentioning

confidence: 99%

Individuals lacking the Gerbich blood-group antigen have alterations in the human erythrocyte membrane sialoglycoproteins β and γ

Anstee¹,

Ridgwell²,

Tanner³

et al. 1984

Biochemical Journal

143

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Membranes from erythrocytes with a new Gerbich (Ge)-negative phenotype (Leach phenotype), as well as those from two other Ge-negative phenotypes, were examined. Whereas cells of the Leach phenotype apparently lack three minor sialoglycoproteins (beta, beta 1 and gamma), the membranes of Ge- Yus- and Ge- Yus+ erythrocytes apparently lack beta- and gamma-sialoglycoproteins but contain additional diffusely migrating components of apparent Mr 30 500-34 500 and 32 500-36 500 respectively. Immunoprecipitation experiments showed that the abnormal components of both Ge- Yus- and Ge- Yus+ erythrocytes reacted with two monoclonal antibodies, BRIC 4 and BRIC 10. These antibodies have been shown to react with sialoglycoproteins beta and beta 1 in normal erythrocytes. Cytoskeletal preparations from Ge- Yus- and Ge- Yus+ erythrocyte membranes contained the abnormal components. In contrast with cells of the Leach phenotype, which are elliptocytic, Ge- Yus- and Ge- Yus+ were of normal shape, despite their apparent lack of beta- and gamma-sialoglycoproteins. It seems likely that the abnormal components in these cells contribute to their normal shape. Ovalocytic erythrocytes were shown to incorporate more radioactivity in the sialoglycoprotein-beta 1 region than normal erythrocytes after labelling by the periodate/NaB3H4 technique. It is suggested that abnormal components in Ge- Yus- and Ge- Yus+ erythrocytes result from chromosomal misalignment with unequal crossing-over at meiosis between the genes giving rise to beta-, beta 1- and gamma-sialoglycoproteins.

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The Gerbich Blood Group System, Especially in Melanesians

Cited by 8 publications

References 4 publications

Rare Blood Donors: The Past and the Future

Rare Blood Donors: The Past and the Future

Rare blood types in the Asia Pacific region

Individuals lacking the Gerbich blood-group antigen have alterations in the human erythrocyte membrane sialoglycoproteins β and γ

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