2011
DOI: 10.1371/journal.pone.0018170
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The Ghrelin Signalling System Is Involved in the Consumption of Sweets

Abstract: The gastric-derived orexigenic peptide ghrelin affects brain circuits involved in energy balance as well as in reward. Indeed, ghrelin activates an important reward circuit involved in natural- as well as drug-induced reward, the cholinergic-dopaminergic reward link. It has been hypothesized that there is a common reward mechanism for alcohol and sweet substances in both animals and humans. Alcohol dependent individuals have higher craving for sweets than do healthy controls and the hedonic response to sweet t… Show more

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Cited by 74 publications
(63 citation statements)
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“…Several recent studies have demonstrated that administration of ghrelin increases drug and food seeking behaviour and enhances the rewarding aspects of high-fat diet (Landgren et al 2011a, b;Perello et al 2010). In a progressive ratio task in rats, ghrelin increases sucrose self-administration and activates the main central reward pathways, whereas antagonism at the ghrelin receptor inhibits reward seeking for palatable food Landgren et al 2011b;Skibicka et al 2011a, b). Furthermore, the role of the ghrelinergic system in obesity is a promising target in today's development of anti-obesity drugs (Field et al 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Several recent studies have demonstrated that administration of ghrelin increases drug and food seeking behaviour and enhances the rewarding aspects of high-fat diet (Landgren et al 2011a, b;Perello et al 2010). In a progressive ratio task in rats, ghrelin increases sucrose self-administration and activates the main central reward pathways, whereas antagonism at the ghrelin receptor inhibits reward seeking for palatable food Landgren et al 2011b;Skibicka et al 2011a, b). Furthermore, the role of the ghrelinergic system in obesity is a promising target in today's development of anti-obesity drugs (Field et al 2009).…”
Section: Discussionmentioning
confidence: 99%
“…They concluded that the antagonism of ghrelin can be beneficial in obese individuals (26). Landgren et al (27,28) showed that GHS-R1a antagonism reduces the intake and selfadministration of sucrose in rats as well as saccharin intake in mice. They also reported that AG administration increases the intake of sucrose in rats.…”
Section: European Journal Of Endocrinologymentioning
confidence: 99%
“…Plasma acylated-ghrelin level was positively correlated with carbohydrate consumption, while inversely correlated with fat intake in rat (Beck et al 2002). Peripheral and central acylated-ghrelin injection stimulated dopamine release in NAc, accompanied by increased sucrose consumption (Landgren et al 2011, McCallum et al 2011. In addition, a populationbased genetic study in humans showed that pro-ghrelin gene (GHRL) haplotype was associated with sucrose preference (Landgren et al 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Peripheral and central acylated-ghrelin injection stimulated dopamine release in NAc, accompanied by increased sucrose consumption (Landgren et al 2011, McCallum et al 2011. In addition, a populationbased genetic study in humans showed that pro-ghrelin gene (GHRL) haplotype was associated with sucrose preference (Landgren et al 2011). These observations may have been interpreted to indicate that ghrelin signal may stimulate a reward system in the midbrain and prompt animals to seek foods with a sweet taste such as sucrose.…”
Section: Discussionmentioning
confidence: 99%
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