The Gingival Crevicular Fluid Levels of Interleukin‐11 and Interleukin‐17 in Patients With Aggressive Periodontitis

Abstract

The IL-11/IL-17 ratio was decreased in the GAgP group because of the decreased IL-11 levels. The IL-11/IL-17 axis and the link between IL-17 and neutrophil function disorders in AgP should be investigated to clarify the role of the IL-11/IL-17 axis and its balance and imbalance in the pathogenesis of AgP.

Salivary Concentrations of Interleukin (IL)‐1β, IL‐17A, and IL‐23 Vary in Relation to Periodontal Status

“…In most studies on IL‐17 and/or IL‐23, only one diseased group, consisting of patients with advanced periodontitis, has been compared with control group. GCF 43 , 44 or gingival tissue biopsies 45 , 46 have been generally used as study specimens. In a study by Lester et al, 45 a moderate periodontitis group was also included, and authors found increased IL‐17A concentrations with progression of periodontitis.…”

Bradykinin promotes Toll like receptor-4 expression in human gingival fibroblasts

“…However, overproduction of cytokines from chronic TLR stimulation leads to destruction of tissue. In gingival fibroblasts, cytokines promote the synthesis of IL-8, IL-1β, IL-10, and prostaglandin E2 [39].…”

Levels of IL-17, RANKL and OPG in Gingival Crevicular Fluid Obtained from Patients with Severe Orthodontic Root Resorption

“…Ay et al (25) reported that the total amount of IL-17 in GCF from aggressive periodontitis was significantly higher than that of the healthy group. Yamaguchi et al (26) demonstrated that the immunoreactivity for Th17, IL-17, IL-17R, RANKL and RANK in the rheumatoid arthritis model mice was significantly higher in the PDL tissue subjected to orthodontic force on day 9 when compared with the normal healthy group.…”