The GISA call to action for the appropriate use of antimicrobials and the control of antimicrobial resistance in Italy

Menichetti, Francesco; Falcone, Marco; Lopalco, Pietro Luigi; Tascini, Carlo; Pan, Angelo; Busani, Luca; Viaggi, Bruno; Rossolini, Gian María; Arena, Fabio; Novelli, Andréa; Rosa, Francesco Giuseppe De; Iannazzo, Stefania; Cohen, Jonathan

doi:10.1016/j.ijantimicag.2018.05.010

Cited by 23 publications

(13 citation statements)

References 38 publications

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“…Laboratory-based surveillance of MDROs should be associated to a careful infection monitoring -e.g. of incidence of urinary tract infections or central line associated bacteremia-, by healthcare providers within the LTCF, and should also be paralleled by evaluation of the consumption of antibiotics in the institution, as key prerequisites for the implementation of an infection control and antimicrobial stewardship programs [22,23]. In any case, routine environmental cultures or samples from asymptomatic personnel are not recommended, except as target for an epidemiologic investigation.…”

Section: Surveillance Recommendations For Mdros In Italian Ltcfsmentioning

confidence: 99%

Recommendations for the surveillance of multidrug-resistant bacteria in Italian long-term care facilities by the GLISTer working group of the Italian Association of Clinical Microbiologists (AMCLI)

Aschbacher

Pagani

Migliavacca

et al. 2020

Antimicrob Resist Infect Control

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Long-term care facilities (LTCFs) are an important reservoir of multidrug-resistant organisms (MDROs). Colonization of LTCF residents by MDROs is generally higher in Italy compared to other European countries. The present review by the working group for the study of infections in LTCFs (GLISTer) of the Italian Association of Clinical Microbiologists (AMCLI) aims to propose criteria for a laboratory-based surveillance of MDROs in Italian LTCFs. We recommend the adhesion to three levels of laboratory-based MDROs surveillance in LTCFs: i) mandatory MDRO surveillance by cumulative retrospective analysis of antimicrobial susceptibility data, obtained as part of routine care of clinical specimens. ii) strongly recommended surveillance by active rectal swab cultures or molecular screening to determine colonization with carbapenemase-producing Enterobacterales, should a resident be proven infected. iii) voluntary surveillance by prospective MDRO surveys, mainly based on point prevalence colonization studies, allowing to determine the MDROs baseline prevalence in the facility. Laboratory-based surveillance of MDROs in LTCFs is aimed at providing useful epidemiological information to healthcare providers operating in the facility, but it is only effective if the collected data are used for infection prevention and control purposes, targeting the peculiar aspects of LTCFs.

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Section: Surveillance Recommendations For Mdros In Italian Ltcfsmentioning

confidence: 99%

Recommendations for the surveillance of multidrug-resistant bacteria in Italian long-term care facilities by the GLISTer working group of the Italian Association of Clinical Microbiologists (AMCLI)

Aschbacher

Pagani

Migliavacca

et al. 2020

Antimicrob Resist Infect Control

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“…19 Above all, the hypothesis is not supported by the findings of AMR country visits carried out by the ECDC in recent years within high-prescribing EU/EEA countries. 20 A study of this specific focus will invariably have some limitations. Other factors not included in the model, such as population, geographic distribution, pharmaceutical availabilities and healthcare structures, could be relevant drivers of Br-Ab prescribing behaviour.…”

Section: Masculinity (Mas)mentioning

confidence: 99%

Broad-spectrum antibiotic use in Europe: more evidence of cultural influences on prescribing behaviour

Borg

Camilleri

2019

Journal of Antimicrobial Chemotherapy

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Objectives Sociocultural factors have been hypothesized as important drivers of inappropriate antibiotic prescribing in European ambulatory care. This study sought to assess whether they can also explain the reported variation in broad-spectrum antibiotic (Br-Ab) use among EU/European Economic Area (EEA) countries. Methods Correlation and regression analysis were performed, using the bootstrap method, between Br-Ab ratios reported from 28 EU countries by the ECDC, and national Hofstede cultural dimensions and control of corruption (CoC) scores. Results Significant bootstrapping correlation coefficients were identified between Br-Ab ratios and the dimension of uncertainty avoidance (UAI) as well as CoC. However, following both bootstrapping multiple regression and generalized linear modelling, only UAI was retained as the sole predictor. A logarithmic model explained 58.6% of the variation in European Br-Ab variability solely using national UAI scores (P < 0.001). Conclusions Br-Ab prescribing appears to be driven by the level of UAI within the country. Any interventions aimed at reducing Br-Ab in high-consuming EU/EEA countries need to address this cultural perception to maximize their chances of success.

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“…It has particular importance since reducing the spread of MDRO represents one of the priorities worldwide [100]. New mechanisms of resistance are continuously emerging, leading to delayed diagnosis and worse patient outcome [101]. This paper has the following goals:…”

Section: Expert Opinionmentioning

confidence: 99%

Diagnostic stewardship based on patient profiles: differential approaches in acute versus chronic infectious syndromes

Tiseo

Arena

Borrè³

et al. 2021

Expert Review of Anti-infective Therapy

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The GISA call to action for the appropriate use of antimicrobials and the control of antimicrobial resistance in Italy

Cited by 23 publications

References 38 publications

Recommendations for the surveillance of multidrug-resistant bacteria in Italian long-term care facilities by the GLISTer working group of the Italian Association of Clinical Microbiologists (AMCLI)

Recommendations for the surveillance of multidrug-resistant bacteria in Italian long-term care facilities by the GLISTer working group of the Italian Association of Clinical Microbiologists (AMCLI)

Broad-spectrum antibiotic use in Europe: more evidence of cultural influences on prescribing behaviour

Diagnostic stewardship based on patient profiles: differential approaches in acute versus chronic infectious syndromes

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