The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system

Bouyakdan, Khalil; Martin, Hugo; Liénard, Fabienne; Budry, Lionel; Taïb, Bouchra; Rodaros, Demetra; Chrétien, Chloé; Biron, Éric; Husson, Zoé; Cota, Daniela; Pénicaud, Luc; Fulton, Stephanie; Fioramonti, Xavier; Alquier, Thierry

doi:10.1172/jci123454

Cited by 62 publications

(115 citation statements)

References 59 publications

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“…We and other authors detected recombination in all tanycytic subpopulations [26,53], in contrast to studies that found CRE activity only in α-tanycytes [46,47,54]. Gfap mRNA is highly expressed in α-tanycytes and ependymal cells in mice [18], which is in agreement with the recombination observed in Gfap-Cre mice (B6.Cg-Tg(Gfap-cre)73.12Mvs/J, 012886) [55][56][57] and hGFAP-CreER T2 (Tg(GFAP-cre/Esr1 * )10Kdmc). In contrast, other Cre lines driven by a human GFAP-promoter (hGFAP-Cre (FVB-Tg[GFAP-cre]25Mes/J [58] and hGFAP-CreER T2 (Tg(GFAP-cre/ERT2)1Fki [51]) are inactive in tanycytes [24,54].…”

Section: Available Transgenic Mice To Manipulate Tanycytessupporting

confidence: 86%

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Müller-Fielitz

Schwaninger

2019

Exp Clin Endocrinol Diabetes

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Thyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.

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Section: Available Transgenic Mice To Manipulate Tanycytessupporting

confidence: 86%

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Müller-Fielitz

Schwaninger

2019

Exp Clin Endocrinol Diabetes

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“…One of these, FABP7, has been proposed to function in glial cells within the ARC to impair leptin signaling especially on HFD 34 . Several studies demonstrated a key role of glial cells on leptin and feeding regulation by the hypothalamus [53][54][55][56][57][58] .…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice

Adlanmérini¹,

Nguyen²,

Krusen³

et al. 2021

Journal of Clinical Investigation

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“…Thus, under normal conditions it is possible that NTS astrocytes and vagliocytes may secrete ODN to regulate food intake. Indeed, in the arcuate nucleus of the hypothalamus astrocytes release ACBP (cleaved extracellularly to ODN), which activates pro-opiomelanocortin neurons to supress appetite via its G-protein coupled receptor ODN-GPCR [114] .…”

Section: Regulation Of Physiology By Nts Astrocytesmentioning

confidence: 99%

Astrocytes in the nucleus of the solitary tract: Contributions to neural circuits controlling physiology

Macdonald

Ellacott

2020

Physiology & Behavior

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The nucleus of the solitary tract (NTS) is the primary brainstem centre for the integration of physiological information from the periphery transmitted via the vagus nerve. In turn, the NTS feeds into downstream circuits regulating physiological parameters. Astrocytes are glial cells which have key roles in maintaining CNS tissue homeostasis and regulating neuronal communication. Recently an increasing number of studies have implicated astrocytes in the regulation of synaptic transmission and physiology. This review aims to highlight evidence for a role for astrocytes in the functions of the NTS. Astrocytes maintain and modulate NTS synaptic transmission contributing to the control of diverse physiological systems namely cardiovascular, respiratory, glucoregulatory, and gastrointestinal. In addition, it appears these cells may have a role in central control of feeding behaviour. As such these cells are a key component of signal processing and physiological control by the NTS.

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The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system

Cited by 62 publications

References 59 publications

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice

Astrocytes in the nucleus of the solitary tract: Contributions to neural circuits controlling physiology

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