The Global Alliance for Chronic Diseases

Daar, Abdallah S.; Nabel, Elizabeth G.; Pramming, Stig; Anderson, Warwick P.; Beaudet, Alain; Liu, Depei; Katoch, Vishwa Mohan; Borysiewicz, Leszek K.; Glass, Roger I.; Bell, John I.

doi:10.1126/science.324_1642

Cited by 26 publications

(14 citation statements)

References 2 publications

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“…Recently, the Global Alliance for Chronic Disease (GACD) was created to address this imbalance issue [32]. The GACD brings together 6 major national health research councils representing 80% of all public research funding in the world to coordinate research activities that address the prevention and treatment of chronic disease on a global scale.…”

Section: Discussionmentioning

confidence: 99%

Geographical Representativeness of Published and Ongoing Randomized Controlled Trials. The Example of: Tobacco Consumption and HIV Infection

et al. 2011

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BackgroundThe challenge for evidence-based healthcare is to reduce mortality and the burden of diseases. This study aimed to compare where research is conducted to where research is needed for 2 public health priorities: tobacco consumption and HIV infection.MethodsWe identified randomized controlled trials (RCTs) included in Cochrane systematic reviews published between 1997 and 2007 and registered ongoing RCTs identified in January 2009 through the World Health Organization's International Clinical Trials Registry Platform (WHO-ICTRP) evaluating interventions aimed at reducing or stopping tobacco use and treating or preventing HIV infection. We used the WHO and World Bank reports to classify the countries by income level, as well as map the global burden of disease and mortality attributable to tobacco use and HIV infection to the countries where the trials performed.ResultsWe evaluated 740 RCTs included in systematic reviews and 346 ongoing RCTs. For tobacco use, 4% of RCTs included in systematic reviews and 2% of ongoing trials were performed in low- and middle-income countries, even though these countries represented 70% of the mortality related to tobacco use. For HIV infection, 31% of RCTs included in systematic reviews and 33% of ongoing trials were performed in low- and middle-income countries, even though these countries represented 99% of the mortality related to HIV infection.ConclusionsOur results highlight an important underrepresentation of low- and middle-income countries in currently available evidence (RCTs included in systematic reviews) and awaiting evidence (registered ongoing RCTs) for reducing or stopping tobacco use and treating or preventing HIV infection.

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Section: Discussionmentioning

confidence: 99%

Geographical Representativeness of Published and Ongoing Randomized Controlled Trials. The Example of: Tobacco Consumption and HIV Infection

et al. 2011

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“…Country-and region-specific studies that cover the broad research spectrum of basic science to advocacy and policy are needed. Governmental and non-governmental efforts, including those by the Global Alliance for Chronic Diseases (Daar et al 2009) and the National Heart, Lung and Blood Institute (Fuster and Kelly 2010), facilitate NCD research and garner global support for multinational collaboration. It is important to re-calibrate the resource base for implementation research to identify best practices in both developed countries and LMIC.…”

Section: Researchmentioning

confidence: 99%

UN resolution on the prevention and control of non-communicable diseases: An opportunity for global action

Mamudu¹,

Yang²,

Novotny³

2011

Global Public Health

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In May 2010, the United Nations (UN) General Assembly unanimously adopted a resolution on non-communicable diseases (NCDs) that called for high-level meetings to address the global burden of NCDs. This paper highlights the growing global burden of NCDs (cardiovascular diseases, cancer, chronic obstructive pulmonary diseases and diabetes), provides a brief historical background on the adoption of the UN NCDs resolution and argues that the resolution provides a remarkable new opportunity for improved international collaboration to address NCDs. Additionally, the paper argues that while the existing World Health Organisation programme on NCDs be continued and expanded, the UN can provide the expanded political leadership that is necessary for multi-sectoral collaboration and can serve as a respected forum for dealing with the issue across numerous key UN agencies.

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“…The recently announced global alliance for chronic disease (GACD- [19]) addresses the increasing consensus that emerging economies face not only malnutrition but also the development of chronic diseases, a double economic and health burden. Education of health care providers, the public, and government officials is needed for demonstrating the universal nature of the HVP's and NuGO's research efforts, the need to include populations in developing countries, and the benefits from cooperating in biomedical research ( [8,13,53,62].…”

Section: Emerging Countriesmentioning

confidence: 99%

Connecting the Human Variome Project to nutrigenomics

et al. 2010

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Nutrigenomics is the science of analyzing and understanding gene-nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that *90% of genetic variation has not yet been characterized. Identification of the DNA sequence variants that contribute to nutrition-related disease risk is essential for developing a better understanding of the complex causes of disease in humans, including nutrition-related disease. The Human Variome Project (HVP; http://www.humanvariomeproject. org/) is an international effort to systematically identify genes, their mutations, and their variants associated with phenotypic variability and indications of human disease or phenotype. Since nutrigenomic research uses genetic information in the design and analysis of experiments, the HVP is an essential collaborator for ongoing studies of gene-nutrient interactions. With the advent of next generation sequencing methodologies and the understanding of the undiscovered variation in human genomes, the nutrigenomic community will be generating novel sequence data and results. The guidelines and practices of the HVP can guide and harmonize these efforts.

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The Global Alliance for Chronic Diseases

Cited by 26 publications

References 2 publications

Geographical Representativeness of Published and Ongoing Randomized Controlled Trials. The Example of: Tobacco Consumption and HIV Infection

Geographical Representativeness of Published and Ongoing Randomized Controlled Trials. The Example of: Tobacco Consumption and HIV Infection

UN resolution on the prevention and control of non-communicable diseases: An opportunity for global action

Connecting the Human Variome Project to nutrigenomics

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