The Global Burden of Obesity and the Challenges of Prevention

Seidell, Jacob C.; Halberstadt, Jutka

doi:10.1159/000375143

Cited by 638 publications

(405 citation statements)

References 17 publications

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“…Os principais fatores envolvidos no desenvolvimento da obesidade têm sido relacionados com fatores ambientais, como ingestão alimentar inadequada e redução no gasto calórico diário 5 . A insatisfação corporal e muitos estudos relativos à imagem corporal, estão relacionados à obesidade, que atualmente é uma epidemia global [6][7][8] . Atualmente, a obesidade está presente em todas as faixas etárias.…”

Section: Descriptorsunclassified

Imagem Corporal, Perfil Lipídico E Nível De Atividade Física De Mulheres Em Projeto De Emagrecimento

VIANA¹,

SANTOS²,

MONTEIRO³

2017

Rev. bras. ciênc. Saúde

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Section: Descriptorsunclassified

Imagem Corporal, Perfil Lipídico E Nível De Atividade Física De Mulheres Em Projeto De Emagrecimento

VIANA¹,

SANTOS²,

MONTEIRO³

2017

Rev. bras. ciênc. Saúde

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“…The 'how' prevention is carried out is a large chapter beyond the present scope and can be seen elsewhere for children [27][28][29] and adults [30]. The individual preventive actions are based on four points:…”

Section: Types Of Preventionmentioning

confidence: 99%

Lights and Shadows on Pediatric Obesity Prevention

Manuel¹

2017

AOWMC

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In order to gain effectiveness against the worldwide spread of obesity it has been recommended by high health offices and scientific societies caring for adults to begin at the earliest possible time. This was also the pediatric point of view based on prevalence trends, clinical burden (comorbidities already in pediatric age), tracking and poor therapeutic results. Because of the population growth this problem will not be solved easily. Types of prevention:The three levels of prevention primary (before the disease), secondary (latent disease) and tertiary (for disease consequences) plus the fourth holistic level, when carried out in practice fall on the classical questions: What, When and How, issued by WHO Population Health Promotion. What kind of prevention? The answer would be general and individual. The general approach is crowded by a great extent of plans and guidelines; therefore the evidence based policies are and will be applied to clear the overlapping and sometimes confusing panorama. Who is the recipient of prevention? This has been changed because of the notion of earliest prevention that should start preconceptionally, going on during pregnancy and newborn period. The negative consequences of high birth weight are clearly demonstrated. Even the classical age to start prevention (4-6 years) is receding in favor of the early rebound of BMI. How prevention is carried out? The present ways should be based on demonstrated plans, but a lot of very varied norms appear, although these seem unable to improve the problem. New interventions for pediatric population are analyzed and the common points of action are: Reduction of energy intake, Increase energy expenditure, Involvement of parents/ family, appropriate information to child or adolescent.In this panorama of good prevention programs yet increased prevalence trends of obesity in the world it is clear that something new must be done but it has not been defined yet. In the meantime this succinct analysis of positive facts and done negative issues, will perhaps contribute step by step to improve the obesity prevention future.

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“…Obesity rates in humans are increasing globally (Seidell and Halberstadt 2015;Swinburn et al 2011). Obesity is associated with numerous comorbidities such as hypertension, Type 2 diabetes mellitus, and coronary heart disease (Malnick and Knobler 2006;Pi-Sunyer 2002).…”

Section: Introductionmentioning

confidence: 99%

A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes

et al. 2016

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Brown bears (Ursus arctos) exhibit hyperphagia each fall and can become obese in preparation for hibernation. They do this without displaying the physiological problems typically seen in obese humans, such as Type 2 diabetes and heart disease. The study of brown bear hibernation biology could therefore aid in the development of novel methods for combating metabolic diseases. To this end, we isolated mesenchymal stem cells from subcutaneous fat biopsies, and culture methods were developed to differentiate these into the adipogenic lineage. Biopsies were taken from 8 captive male (N = 6) and female (N = 2) brown bears, ages 2-12 years. Plastic adherent, fibroblast-like cells were proliferated and subsequently cryopreserved or differentiated. Differentiation conditions were optimized with respect to fetal bovine serum content and time spent in differentiation medium. Cultures were characterized through immunostaining, RT-qPCR, and Oil red O staining to quantify lipid accumulation. Adiponectin, leptin, and glycerol medium concentrations were also determined over the course of differentiation. The culturing protocol succeeded in generating hormone-sensitive lipase-expressing, lipid-producing white-type adipocytes (UCP1 negative). Serum concentration and time of exposure to differentiation medium were both positively related to lipid production. Cells cultured to low passage numbers retained similar lipid production and expression of lipid markers PLIN2 and FABP4. Ultimately, the protocols described here may be useful to biologists in the field investigating the health of wild bear populations and could potentially increase our understanding of metabolic disorders in humans.

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The Global Burden of Obesity and the Challenges of Prevention

Cited by 638 publications

References 17 publications

Imagem Corporal, Perfil Lipídico E Nível De Atividade Física De Mulheres Em Projeto De Emagrecimento

Imagem Corporal, Perfil Lipídico E Nível De Atividade Física De Mulheres Em Projeto De Emagrecimento

Lights and Shadows on Pediatric Obesity Prevention

A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes

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